3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones

ABSTRACT

Compounds of formula (I) as described hereinprocesses for their production and their use as anti-cancer agents.

FIELD OF APPLICATION OF THE INVENTION

The invention relates to substituted tetrahydro-4H-indol-4-one compounds, processes for their production and uses thereof.

BACKGROUND OF THE INVENTION

One of the most fundamental characteristics of cancer cells is their ability to sustain chronic proliferation whereas in normal tissues the entry into and progression through the cell divison cycle is tightly controlled to ensure a homeostasis of cell number and maintenance of normal tissue function. Loss of proliferation control was emphasized as one of the six hallmarks of cancer [Hanahan D and Weinberg R A, Cell 100, 57, 2000; Hanahan D and Weinberg R A, Cell 144, 646, 2011].

The eukaryotic cell division cycle (or cell cycle) ensures the duplication of the genome and its distribution to the daughter cells by passing through a coordinated and regulated sequence of events. The cell cycle is divided into four successive phases:

1. The G1 phase represents the time before the DNA replication, in which the cell grows and is sensitive to external stimuli.

2. In the S phase the cell replicates its DNA, and

3. in the G2 phase preparations are made for entry into mitosis.

4. In mitosis (M phase), the duplicated chromosomes get separated supported by a spindle device built from microtubules, and cell division into two daughter cells is completed.

To ensure the extraordinary high fidelity required for an accurate distribution of the chromosomes to the daughter cells, the passage through the cell cycle is strictly regulated and controlled. The enzymes that are necessary for the progression through the cycle must be activated at the correct time and are also turned off again as soon as the corresponding phase is passed. Corresponding control points (“checkpoints”) stop or delay the progression through the cell cycle if DNA damage is detected, or the DNA replication or the creation of the spindle device is not yet completed. The mitotic checkpoint (also known as spindle checkpoint or spindle assembly checkpoint) controls the accurate attachment of mircrotubules of the spindle device to the kinetochors (the attachment site for microtubules) of the duplicated chromosomes. The mitotic checkpoint is active as long as unattached kinetochores are present and generates a wait-signal to give the dividing cell the time to ensure that each kinetochore is attached to a spindle pole, and to correct attachment errors. Thus the mitotic checkpoint prevents a mitotic cell from completing cell division with unattached or erroneously attached chromosomes [Suijkerbuijk S J and Kops G J, Biochem. Biophys. Acta 1786, 24, 2008; Musacchio A and Salmon E D, Nat. Rev. Mol. Cell. Biol. 8, 379, 2007]. Once all kinetochores are attached with the mitotic spindle poles in a correct bipolar (amphitelic) fashion, the checkpoint is satisfied and the cell enters anaphase and proceeds through mitosis.

The mitotic checkpoint is established by a complex network of a number of essential proteins, including members of the MAD (mitotic arrest deficient, MAD 1-3) and Bub (Budding uninhibited by benzimidazole, Bub 1-3) families, Mpsl kinase, cdc20, as well as other components [reviewed in Bolanos-Garcia V M and Blundell T L, Trends Biochem. Sci. 36, 141, 2010], many of these being over-expressed in proliferating cells (e.g. cancer cells) and tissues [Yuan B et al., Clin. Cancer Res. 12, 405, 2006]. The major function of an unsatisfied mitotic checkpoint is to keep the anaphase-promoting complex/cyclosome (APC/C) in an inactive state. As soon as the checkpoint gets satisfied the APC/C ubiquitin-ligase targets cyclin B and securin for proteolytic degradation leading to separation of the paired chromosomes and exit from mitosis.

Inactive mutations of the Ser/Thr kinase Bub1 prevented the delay in progression through mitosis upon treatment of cells of the yeast S. cerevisiae with microtubule-destabilizing drugs, which led to the identification of Bub1 as a mitotic checkpoint protein [Roberts BT et al., Mal. Cell Biol., 14, 8282, 1994]. A number of recent publications provide evidence that Bub1 plays multiple roles during mitosis which have been reviewed by Elowe [Elowe S, Mol. Cell. Biol. 31, 3085, 2011]. In particular, Bub1 is one of the first mitotic checkpoint proteins that binds to the kinetochores of duplicated chromosomes and probably acts as a scaffolding protein to constitute the mitotic checkpoint complex. Furthermore, via phosphorylation of histone H2A, Bub1 localizes the protein shugoshin to the centromeric region of the chromosomes to prevent premature segregation of the paired chromosomes [Kawashima et al. Science 327, 172, 2010]. In addition, together with a Thr-3 phosphorylated Histone H3 the shugoshin protein functions as a binding site for the chromosomal passenger complex which includes the proteins survivin, borealin, INCENP and Aurora B. The chromosomal passenger complex is seen as a tension sensor within the mitotic checkpoint mechanism, which dissolves erroneously formed microtubule-kinetochor attachments such as syntelic (both sister kinetochors are attached to one spindle pole) or merotelic (one kinetochor is attached to two spindle poles) attachments [Watanabe Y, Cold Spring Harb. Symp. Quant. Biol. 75, 419, 2010]. Recent data suggest that the phosphorylation of histone H2A at Thr 121 by Bub1 kinase is sufficient to localize AuroraB kinase to fulfill the attachment error correction checkpoint [Ricke et al. J. Cell Biol. 199, 931-949, 2012].

Incomplete mitotic checkpoint function has been linked with aneuploidy and tumourigenesis [Weaver B A and Cleveland D W, Cancer Res. 67, 10103, 2007; King R W, Biochim Biophys Acta 1786, 4, 2008]. In contrast, complete inhibition of the mitotic checkpoint has been recognised to result in severe chromosome missegregation and induction of apoptosis in tumour cells [Kops GJ et al., Nature Rev. Cancer 5, 773, 2005; Schmidt M and Medema RH, Cell Cycle 5, 159, 2006; Schmidt M and Bastians H, Drug Res. Updates 10, 162, 2007]. Thus, mitotic checkpoint abrogation through pharmacological inhibition of components of the mitotic checkpoint, such as Bub1 kinase, represents a new approach for the treatment of proliferative disorders, including solid tumours such as carcinomas, sarcomas, leukaemias and lymphoid malignancies or other disorders, associated with uncontrolled cellular proliferation.

The present invention relates to chemical compounds that inhibit Bub1 kinase.

Established anti-mitotic drugs such as vinca alkaloids, taxanes or epothilones activate the mitotic checkpoint, inducing a mitotic arrest either by stabilising or destabilising microtubule dynamics. This arrest prevents separation of the duplicated chromosomes to form the two daughter cells. Prolonged arrest in mitosis forces a cell either into mitotic exit without cytokinesis (mitotic slippage or adaption) or into mitotic catastrophe leading to cell death [Rieder C L and Maiato H, Dev. Cell 7, 637, 2004]. In contrast, inhibitors of Bub1 prevent the establishment and/or functionality of the mitotic checkpoint and interfere with spindle attachment error correction, which finally results in severe chromosomal missegregation, induction of apoptosis and cell death.

These findings suggest that Bub1 inhibitors should be of therapeutic value for the treatment of proliferative disorders associated with enhanced uncontrolled proliferative cellular processes such as, for example, cancer, inflammation, arthritis, viral diseases, cardiovascular diseases, or fungal diseases in a warm-blooded animal such as man.

WO 2013/050438, WO 2013/092512, WO 2013/167698, WO 2014/147203, WO 2014/147204, WO2014202590, WO2014202588, WO2014202584, WO2014202583 WO2015/063003, disclose substituted indazoles, substituted pyrazoles, and substituted cycloalkylpyrazoles, which are Bub1 kinase inhibitors.

WO2015/193339 discloses 3-Amino-1,5,6,7-tetrahydro-4H-indol-4-ones which are Bub1 kinase inhibitors.

Due to the fact that especially cancer disease as being expressed by uncontrolled proliferative cellular processes in tissues of different organs of the human- or animal body still is not considered to be a controlled disease in that sufficient drug therapies already exist, there is a strong need to provide further new therapeutically useful drugs, preferably inhibiting new targets and providing new therapeutic options (e.g. drugs with improved pharmacological properties).

Description of the Invention

Therefore, inhibitors of Bub1 represent valuable compounds that should complement therapeutic options either as single agents or in combination with other drugs.

In accordance with a first aspect, the invention relates to a compound of formula (I),

in which:

-   -   R¹ represents hydrogen or C₁-C₆-alkyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl             group is optionally substituted, one or more times,             independently from each other, with R⁴,     -   R³ represents hydrogen or C₁-C₆-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl,         C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy,         C₁-C₄-hydroxyalkyl, C₁-C₄-alkyl-C(O)—, R¹⁰—O— C(O)—,         R⁷R⁸N—C(O)—, C₁-C₄-alkyl-C(O)—NH—, R⁷R⁸N—, or R⁷R⁸N—SO₂—;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, hydroxy,         nitro, cyano, R⁹R¹⁰N—, (R¹³—C(O)—)(R¹⁴—C(O)—)N—, C₁-C₄-alkyl,         C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₄-haloalkyl,         C₁-C₆-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy,             C₃-C₆-cycloalkyl, and 4- to 6-membered heterocycloalkyl,

    -   Q represents O or N—OH;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, nitro, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted,             one or more times, independently from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, nitro, cyano, C₁-C₆-alkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or             C₁-C₄-haloalkoxy;

    -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl             optionally substituted one time with hydroxy, 4- to             6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴;         -   or,

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 7-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O, NR⁹ and S, and which may be         optionally substituted, one or more times, independently from         each other, with R¹²;         -   whereby when two R¹² substituents are attached to the same             ring carbon atom, together with the carbon atom to which             they are attached, can be linked to one another in such a             way that they jointly form a cyclobutane, azetidine, or             oxetane group;         -   said azetidine being optionally substituted one time with             C₁-C₃-alkyl,

    -   or,

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a group selected from :

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule,

    -   R⁹ represents hydrogen,or C₁-C₆-alkyl;

    -   R¹⁰ represents hydrogen, C₁-C₆-alkyl or C₃-C₆-cycloalkyl;

    -   R¹¹ represents hydroxy, nitro, cyano, C₃-C₆-cycloalkyl, 4- to         6-membered heterocycloalkyl, C₁-C₄-alkyl-C(O)—, R¹⁰—O—C(O)—,         R⁷R⁹N—C(O)—, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R⁷R⁸N—, N₃—,         R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—,         R⁶—S—, R⁶—SO—, R⁶—SO₂—, R⁷R⁸N—SO₂—;         -   wherein said C₃-C₆-cycloalkyl or 4- to 6-membered             heterocycloalkyl groups are optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl             or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkyl,         C₁-C₄-haloalkoxy, or R⁹R¹⁰N—;

    -   R^(13,) R¹⁴ represent, independently from each other,         C₁-C₄-alkyl, or C₃C₆-cycloalkyl,         -   wherein said C₃-C₆-cycloalkyl is optionally substituted, one             or more times, independently from each other, with halogen;

    -   m represents 0, 1 or 2;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a second aspect, the invention relates to compounds of formula (I) as described supra,

wherein:

-   -   R¹ represents hydrogen or C₁-C₄-alkyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl             group is optionally substituted, one or more times,             independently from each other, with R⁴.     -   R³ represents hydrogen or C₁-C₄-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen, hydroxy, nitro, cyano, C₁-C₄-alkoxy,         C₁-C₄-haloalkyl, or C₁-C₄-haloalkoxy;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, hydroxy,         cyano, R⁹R¹⁰N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl,         C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₆-cycloalkyl;

    -   Q represents O or N—OH;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted,             one or more times, independently from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or             C₁-C₄-haloalkoxy;

    -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl             optionally substituted one time with hydroxy, 4- to             6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴;

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 7-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O, NR⁹ and S, and which may be         optionally substituted, one or more times, independently from         each other, with R¹²;

    -   R⁹ represents hydrogen or C₁-C₄-alkyl;

    -   R¹⁰ represents hydrogen, C₁-C₄-alkyl, or C₃-C₄-cycloalkyl;

    -   R¹¹ represents hydroxy, cyano, C₃-C₆-cycloalkyl, 4- to         6-membered heterocycloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,         R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—,         R⁶—SO₂—R⁹—, R⁶—S—, or R⁶—SO—, R⁶—SO₂—;         -   wherein said C₃-C₆-cycloalkyl or 4- to 6-membered             heterocycloalkyl groups are optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl             or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy,         C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, or R⁹R¹⁰N—;

    -   m represents 0, 1 or 2;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a third aspect, the invention relates to compounds of formula (I) as described supra, wherein:

-   -   R¹ represents hydrogen or C₁-C₂-alkyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is             optionally substituted, one or more times, independently             from each other, with R⁴,     -   R³ represents hydrogen or C₁-C₄-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, R⁹R¹⁰N—,         C₁—C₄-alkoxy, C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₄-cycloalkyl;

    -   Q represents O;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁸N— or phenyl             optionally substituted, one or more times, independently             from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, C₁-C₄-alkyl,             tert-butyl-O—C(O)—, or C₁-C₄-alkoxy;

    -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₄-cycloalkyl, tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R^(4;)

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or more times, independently from each other,         with R¹²;

    -   R⁹ represents hydrogen or C₁-C₂-alkyl;

    -   R¹⁰ represents hydrogen or C₁-C₄-alkyl;

    -   R¹¹ represents hydroxy, 6-membered heterocycloalkyl,         C₁-C₂-alkoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—,         R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—;         -   wherein said 6-membered heterocycloalkyl group is optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkoxy,             C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, C₁-C₂-alkyl, R⁹R¹⁰N—;

    -   m represents 0, or 1;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a fourth aspect, the invention relates to compounds of formula (I) as described supra,

wherein:

-   -   R¹ represents hydrogen or methyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             HO—C(O)—, (CH₃)₂N— or phenyl, wherein said phenyl group is             optionally substituted one, two or three times with F,     -   R³ represents hydrogen, methyl or ethyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or two times, independently from each             other, with R⁴;

    -   R⁴ represents fluoro or chloro;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, fluoro, R⁹R¹⁰N—,         C₁-C₂-alkoxy, difluoroethoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₂-alkoxy is optionally substituted, one or             two times, independently from each other, with a substituent             selected from hydroxy, methoxy, and cyclopropyl;

Q represents O;

-   -   R⁶ represents, independently from each other, C₁-C₅-alkyl,         C₃-C₄-cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or         5- to 6-membered heteroaryl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one, two             or three times, independently from each other, with fluoro,             hydroxy, methoxy, cyclopropyl, or R⁷R⁸N— and optionally             substituted one time with phenyl optionally substituted,             one, two or three times, independently from each other, with             R⁴,         -   wherein said C₃-C₄-cycloalkyl, 5- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one, two or three times, independently from             each other, with fluoro, chloro, hydroxy, methyl,             tert-butyl-O—C(O)—, methoxy;     -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₅-alkyl, cyclopropyl, cyclobutyl, tert-butyl-O—C(O)— or         phenyl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one or             more times, independently from each other, with fluoro,             hydroxy, methoxy, C₃-C₄-cycloalkyl optionally substituted             one time with hydroxy, 5-membered heterocycloalkyl,             5-membered heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one, or             two times, independently from each other, with fluoro or             chloro;     -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or two times, independently from each other,         with R¹²;     -   R⁹ represents hydrogen or methyl;     -   R¹represents hydrogen, methyl or tert-butyl;

R¹¹ represents hydroxy, morpholino, methoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, or R⁸—SO₂—;

-   -   -   wherein said methoxy group is optionally substituted with             phenyl;

    -   R¹² represents fluoro, hydroxy, methyl, or R⁹R¹⁰N—;

    -   m represents 0, or 1;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In another aspect, the invention relates to compounds of formula (I) as described supra,

wherein:

-   -   R¹ represents hydrogen or C₁-C₄-alkyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(CH₂)_(n)—;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl             group is optionally substituted, one or more times,             independently from each other, with R⁴,     -   R³ represents hydrogen or C₁-C₄-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen, hydroxy, nitro, cyano, C₁-C₄-alkoxy,         C₁-C₄-haloalkyl, or C₁-C₄-haloalkoxy;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, hydroxy,         cyano, R⁹R¹⁰N—, C₁-C₁-C₄-alkoxy, C₁-C₄-haloalkyl,         C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₆-cycloalkyl;

    -   Q represents O or N—OH;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted,             one or more times, independently from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkoxy,             C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or C₁-C₄-haloalkoxy;

    -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl             optionally substituted one time with hydroxy, 4- to             6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴;

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 7-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O, NR⁹ and S, and which may be         optionally substituted, one or more times, independently from         each other, with R¹²;

    -   R⁹ represents hydrogen or C₁-C₄-alkyl;

    -   R¹⁰ represents hydrogen, C₁-C₄-alkyl, or C₃-C₄-cycloalkyl;

    -   R¹¹ represents hydroxy, cyano, C₃-C₆-cycloalkyl, 4- to         6-membered heterocycloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,         R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—,         R⁶—SO₂—NR⁹—, R⁶—S—, or R⁶—SO—, R⁶—SO₂—;         -   wherein said C₃-C₆-cycloalkyl or 4- to 6-membered             heterocycloalkyl groups are optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkyl or             C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy,         C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, or R⁹R¹⁰N—;

    -   m represents 0, 1 or 2;

    -   n represents 1, 2, 3 or 4;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In another aspect, the invention relates to compounds of formula (I) as described supra,

wherein:

-   -   R¹ represents hydrogen or C₁-C₂-alkyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(CH₂)_(n)—;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is             optionally substituted, one or more times, independently             from each other, with R⁴,     -   R³ represents hydrogen or C₁-C₄-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, R⁹R¹⁰N—,         C₁—C₄-alkoxy, C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₄-cycloalkyl;

    -   Q represents O;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁸N— or phenyl             optionally substituted, one or more times, independently             from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, C₁-C₄-alkyl,             tert-butyl-O—C(O)—, or C₁-C₄-alkoxy;

    -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₄-cycloalkyl, tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R^(4;)

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or more times, independently from each other,         with R¹²;

    -   R⁹ represents hydrogen or C₁-C₂-alkyl;

    -   R¹⁰ represents hydrogen or C₁-C₂-alkyl;

    -   R¹¹ represents hydroxy, 6-membered heterocycloalkyl,         C₁-C₂-alkoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—,         R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—;         -   wherein said 6-membered heterocycloalkyl group is optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkoxy,             C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, C₁-C₂-alkyl, R⁹R¹⁰N—;

    -   m represents O, or 1;

    -   n represents 1, 2, 3 or 4;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In another aspect, the invention relates to compounds of formula (I) as described supra,

wherein:

-   -   R¹ represents hydrogen or methyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(CH₂)_(n)—;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             HO—C(O)—, (CH₃)₂N— or phenyl, wherein said phenyl group is             optionally substituted one, two or three times with F,     -   R³ represents hydrogen, methyl or ethyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁴ represents fluoro or chloro;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, fluoro, R⁹R¹⁰N—,         C₁-C₂-alkoxy, difluoroethoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁C₂-alkoxy is optionally substituted, one or             two times, independently from each other, with a substituent             selected from hydroxy, methoxy, and cyclopropyl;

Q represents O;

-   -   R⁶ represents, independently from each other, C₁-C₅-alkyl,         C₃-C₄-cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or         5- to 6-membered heteroaryl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one, two             or three times, independently from each other, with fluoro,             hydroxy, methoxy, cyclopropyl, or R⁷R⁸N— and optionally             substituted one time with phenyl optionally substituted,             one, two or three times, independently from each other, with             R⁴,         -   wherein said C₃-C₄-cycloalkyl, 5- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one, two or three times, independently from             each other, with fluoro, chloro, hydroxy, methyl,             tert-butyl-O—C(O)—, methoxy;     -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₅-alkyl, cyclopropyl, tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one or             more times, independently from each other, with fluoro,             hydroxy, methoxy, C₃-C₄-cycloalkyl optionally substituted             one time with hydroxy, 5-membered heterocycloalkyl,             5-membered heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one, or             two times, independently from each other, with fluoro or             chloro;     -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or two times, independently from each other,         with R¹²;     -   R⁹ represents hydrogen or methyl;     -   R¹⁰ represents hydrogen or methyl;     -   R¹¹ represents hydroxy, morpholino, methoxy, R⁷R⁸N—, N₃—,         R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—,         R⁶—S—, or R⁸—SO₂—;         -   wherein said methoxy group is optionally substituted with             phenyl;     -   R¹² represents fluoro, hydroxy, methyl, or R⁹R¹⁰N—;     -   m represents 1, or 1;     -   n represents 1 or 4;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In another aspect, the invention relates to compounds of formula (I) as described supra,

wherein:

-   -   R¹ represents hydrogen or C₁-C₂-alkyl;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is             optionally substituted, one or more times, independently             from each other, with R⁴,     -   R³ represents hydrogen or C₁-C₄-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, R⁹R¹⁰N—,         C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R^(6a)—C(O)—NR⁹—, or         R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₄-cycloalkyl;

    -   Q represents O;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁸N— or phenyl             optionally substituted, one or more times, independently             from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, tert-butyl-O—C(O)—, or             C₁-C₄-alkoxy;

R^(6a)represents, independently from each other, C₁-C₂-alkyl, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl,

-   -   -   wherein said C₁-C₂-alkyl is optionally substituted one time             with halogen, hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl,             R⁷R⁸N— or phenyl optionally substituted, one or more times,             independently from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, C₁-C₄-alkyl,             tert-butyl-O—C(O)—, or C₁-C₄-alkoxy;

R⁷, R⁸ represent, independently from each other, hydrogen, C₁-C₃-alkyl, C₃-C₄-cycloalkyl, tert-butyl-O—C(O)— or phenyl,

-   -   -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴;

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or more times, independently from each other,         with R^(12;)

    -   R^(7a), R^(8a) represent, independently from each other,         hydrogen, C₁-C₄-alkyl, or C₃-C₄-cycloalkyl,         -   wherein said C₁-C₄-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,

    -   R⁹ represents hydrogen or C₁-C₂-alkyl;

    -   R¹⁰ represents hydrogen or C₁-C₄-alkyl;

    -   R¹¹ represents hydroxy, 6-membered heterocycloalkyl,         C₁-C₂-alkoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—,         R^(7a)R^(8a)N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—;         -   wherein said 6-membered heterocycloalkyl group is optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, R⁹R¹⁰N—;

    -   m represents 0, or 1;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In another aspect, the invention relates to compounds of formula (I) as described supra, wherein:

-   -   R¹ represents hydrogen;     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             R¹⁰—O—C(O)—, R⁷R³N— or phenyl, wherein said phenyl group is             optionally substituted, one or more times, independently             from each other, with R⁴,     -   R³ represents hydrogen or C₁-C₄-alkyl;     -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴;

    -   R⁴ represents halogen;

    -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule;

    -   R⁵ represents, independently from each other, halogen, R⁹R¹⁰N—,         C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R^(6a)—C(O)—NR⁹—, or         R⁷R⁶N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₄-cycloalkyl;         -   Q represents O;

    -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁹N— or phenyl             optionally substituted, one or more times, independently             from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, C₁-C₄-alkyl,             tert-butyl-O—C(O)—, or C₁-C₄-alkoxy;

R^(6a) represents, independently from each other, C₁-C₂-alkyl, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl,

-   -   -   wherein said C₁-C₂-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁸N— or phenyl             optionally substituted, one or more times, independently             from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, C₁-C₄-alkyl,             tert-butyl-O—C(O)—, or C₁-C₄-alkoxy;

    -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₃-alkyl, C₃-C₄-cycloalkyl, tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴;

    -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or more times, independently from each other,         with R¹²;

    -   R^(7a)R^(8a) represent, independently from each other, hydrogen,         C₁-C₄-alkyl, or C₃-C₄-cycloalkyl,

    -   wherein said C₁-C₄-alkyl is optionally substituted, one or more         times, independently from each other, with halogen, hydroxy,         C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally substituted one time         with hydroxy, 4- to 6-membered heterocycloalkyl, heteroaryl, or         R⁹R¹⁰N—,

    -   R⁹ represents hydrogen or C₁-C₂-alkyl;

    -   R¹⁰ represents hydrogen or C₁-C₄-alkyl;

    -   R¹¹ represents hydroxy, 6-membered heterocycloalkyl,         C₁-C₂-alkoxy, R⁷R⁹N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—,         R^(7a)R^(8a)N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—;         -   wherein said 6-membered heterocycloalkyl group is optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴,

    -   R¹² represents halogen, hydroxy, R⁹R¹⁰N—;

    -   m represents 0, or 1;

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In accordance with another aspect, the invention relates to a compound of formula (I), which is selected from the group consisting of:

(6RS)-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In accordance with another aspect, the invention relates to a compound of formula (I), which is selected from the group consisting of:

-   -   tert-butyl         [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate,     -   (6RS)-6-[(benzyloxy)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   tert-butyl         [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]carbamate,     -   (6RS)-6-amino-3-anilino-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one         hydrochloride,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]cyclopropanecarboxamide,     -   (6RS)-4-oxo-N-phenyl-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   methyl         (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-hydroxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   methyl         (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   methyl         (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-N-(2-methoxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-ethyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-6-(morpholin-4-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-3-(phenylamino)-2-(pyridin-4-yl)-6-(pyrrolidin-1-ylcarbonyl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-(azetidin-1-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-N-(cyclopropylmethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(cyclopropylmethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-carboxamide,     -   (6RS)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide     -   (6RS)-N-ethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-tert-butyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-(phenylamino)-6-(piperidin-1-ylcarbonyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-4-oxo-3-(phenylamino)-N-(propan-2-yl)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   methyl         (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-6-(azidomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(dimethylamino)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-(hydroxymethyl)-1-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[tert-butyl(dimethyl)silyl]oxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-1-ethyl-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-1-[2-(dimethylamino)ethyl]-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-hydroxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-ethenyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   1-ethyl-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]methylurea,     -   1-cyclopropyl-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea,     -   1-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-3-propan-2-ylurea,     -   1-(furan-2-ylmethyl)-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-yl]methylurea,     -   1-(3-chloro-4-fluorophenyl)-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea,     -   methyl         [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylacetamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylmethanesulfonamide,     -   (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   methyl         (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (4E)-5-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic         acid,     -   (4Z)-5-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic         acid,     -   (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-6-[(E)-2-(4-fluorophenyl)ethenyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(Z)-2-(4-fluorophenyl)ethenyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-(morpholin-4-ylmethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[methyl(propan-2-yl)amino]methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(1E)-3-(dimethylamino)prop-1-en-1-yl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(1Z)-3-(dimethylamino)prop-1-en-1-yl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   1-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-3-(2RS)-(tetrahydrofuran-2-ylmethyl)urea,     -   (6RS)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6R)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-carboxamide,     -   (6RS)-N,N-d         imethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6R)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6S)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6S)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-carboxamide,     -   (6RS)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(ethylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   4-fluoro-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]methylbenzenesulfonamide,     -   2-methoxyethyl         [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-yl]methylcarbamate,     -   2-fluoroethyl         [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]methylcarbamate,     -   (6RS)-6-[(1,3-benzothiazol-2-ylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcyclopropanecarboxamide,     -   2-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide,     -   2-methoxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-yl]methylacetamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcyclobutanecarboxamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropane-2-sulfonamide,     -   (6RS)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6R)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-carboxamide,     -   (6S)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-(3-methoxypyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-(3-fluoropyridin-4-yl)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-hydroxyethyl)-2-(3-methoxypyridin-4-yl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(ethylsulfonyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   3-methoxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide,     -   (6RS)-2-[2-(acetylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-(acetylamino)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,         6,7-tetrahydro-1H-indol-6-carboxylate,     -   methyl         (6R)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   methyl         (6S)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-2-(2-aminopyridin-4-yl)-6-(hydroxymethyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   4-fluoro-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]methylbenzamide,     -   tert-butyl         [(2S)-1-oxo-1-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylamino)propan-2-yl]carbamate,     -   tert-butyl         (2S)-2-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamoyl)pyrrolidine-1-carboxylate,     -   (2S)-2-hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-1,3-thiazole-2-carboxamide,     -   1-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]methyl-1H-pyrrole-2-carboxamide,     -   N-4-[(6RS)-6-(hydroxymethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyltetrahydro-2H-pyran-4-carboxamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylfuran-2-carboxamide,     -   (6RS)-N-(2-hydroxy-2-methylpropyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,         6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(2S)-2-hydroxypropyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(1-hydroxy-2-methylpropan-2-yl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2,2-dimethylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[2-(dimethylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[2-(dimethylamino)ethyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-y1)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-N-[2-(methylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2,2-difluoroethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2,2-difluoroethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-tert-butyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(1-hydroxycyclopropyl)methyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-hydroxy-2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxannide,     -   (6RS)-N-[(2R)-2-hydroxypropyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6R)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6S)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-6-[(4-methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(3-hydroxyazetidin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-N,N-diethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]acetamide,     -   2-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]propanamide,     -   3-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]butanamide,     -   3-hydroxy-3-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide,     -   2-cyclopropyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]acetamide,     -   (3S)-3-hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide,     -   3-hydroxy-2,2-dimethyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,         6,7-tetrahydro-1H-indol-6-yl]propanamide,     -   (6RS)-N-[(2S)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6R)-N-[(2S)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6S)-N-[(2S)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(2R)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6R)-N-[(2R)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (3R)-3-hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide,     -   (6S)-N-[(2R)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[2-(methylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-L-prolinamide,     -   tert-butyl         methyl(3-oxo-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]aminopropyl)carbamate,     -   methyl         (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-6-[(1,3-benzothiazol-2-ylsulfonyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-[2-([(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   methyl         (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   methyl         (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   3,3-dimethyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide,     -   (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   N³-methyl-N-[(6RS)-4-oxo-3-(phelamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-1-6-yl]beta-alaninamide         trifluoroacetate,     -   (6RS)-N-[(1-hydroxycyclobutyl)methyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (4E)-5-[(6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic         acid,     -   methyl         (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   N-4-[(6RS)-6-(azidomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   (6RS)-N-(2-methoxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2,2-dimethylpropyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-4-[(6RS)-6-(aminomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   Methyl         (6RS)-3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-2-[3—(Cyclopropylmethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   Methyl         (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-3-Anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-2-[3-(2-Methoxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-Hydroxyethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   Methyl         (6RS)-3-anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-2-[3-(2-Hydroxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid     -   (6RS)-N-Ethyl-N-(2-hydroxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-Hydroxyethyl)-4-oxo-3-(phenylamino)-N-(propan-2-yl)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(1-Hydroxycyclobutyl)methyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,         6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(2R)-1-Hydroxypropan-2-yl]N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,         6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(2S)-1-Hydroxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,         6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-(4-{(6RS)-3-Anilino-6-methyl-6-[(4-methylpiperazin-1-yl)carbonyl]-4-oxo-4,5,         6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide,     -   (6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(2R,63)-2,6-dimethylmorpholin-4-yl]carbonyl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-(4-{(6RS)-3-Anilino-6-[(3-fluoroazetidin-1-yl)carbonyl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide,     -   N-(4-{(6RS)-3-Anilino-6-[(3,3-difluoroazetidin-1-yl)carbonyl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-ypacetamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-methoxyethyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,N-diethyl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-4-[(6RS)-6-Methyl-6-(2-oxa-6-azaspiro[3.3]hept-6-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-2-methoxypropyl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-1-methoxypropan-2-yl]-N,         6-d         imethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-methoxy-2-methylpropyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,6-dimethyl-4-oxo-3-(phenylamino)-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2,2-d         imethylpropyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-4-[(6RS)-6-[(3R)-3-(Dimethylamino)pyrrolidin-1-yl]carbonyl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-4-[(6RS)-6-Methyl-6-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]         hept-2-yl]carbonyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,6-dimethyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-4-[(6RS)-6-Methyl-6-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylcarbonyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-4-[(6RS)-6-[(Ethylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-ypacetamide,     -   N-4-[(6RS)-6-[(tert-Butylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(S)-propan-2-ylsulfinyl]methyl-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N,N-Dimethyl-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(2-Hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(methylsulfonyl)amino]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-{4-[(6RS)-6-(Acetamidomethyl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-{[(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl}-4′-methoxybiphenyl-4-carboxamide,     -   5-[(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pentanoic         acid,     -   (6RS)-3-Anilino-N,N-diisopropyl-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   Methyl         (6RS)-3-anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-3-Anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6RS)-3-Anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-2-yl}pyridin-2-yl)-4-fluoro-3-methoxybenzamide,     -   N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-2-yl}pyridin-2-yl)-2-fluoro-2-methylpropanamide,     -   1-(4-{(6RS)-3-Anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-2-yl}pyridin-2-yl)-3-cyclopropylurea,     -   1-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-2-yl}pyridin-2-yl)-3-cyclopropylurea,     -   N-{[(6RS)-3-Anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl}-L-alaninamide,     -   (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-N,N-diethyl-2-[2-({[(1S,23)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N-isobutyl-N,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-N-(cyclopropylmethyl)-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (1S,2S)-N-{4-[(6RS)-3-Anilino-6-methyl-4-oxo-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide,     -   (1S,2S)-N-{4-[(6RS)-3-Anilino-6-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}-6-methyl-4-oxo-4,5,         6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide,     -   (1S,2S)-N-{4-[(6RS)-3-Anilino-6-methyl-4-oxo-6-(piperidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide,     -   N-{4-[(6RS)-3-Anilino-6-({[2-(d         imethylamino)ethyl]sulfanyl}methyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,         6,7-tetrahydro-1H-indol-1-2-yl}pyridin-2-yl)-4-fluoro-N-methylbenzamide,     -   (6RS)-2-(2-Aminopyridin-4-yl)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-4,5,6,7-tetrahydro-4H-indol-4-one,     -   N-4-[(6RS)-6-[(2-Methoxyethyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-4-[(6RS)-6-[(1,3—Oxazol-2-ylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-(4-(6RS)-4—Oxo-3-(phenylamino)-6-[(1,3-thiazol-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide,     -   N-(4-(6RS)-4—Oxo-3-(phenylamino)-6-[(pyridin-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide,     -   N-4-[(6RS)-6-[(4-Fluorobenzyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   (1S,2S)-2-Fluoro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)cyclopropanecarboxamide,     -   N-(4-(6RS)-4—Oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)-1,3-thiazole-5-carboxamide,     -   4-Fluoro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide,     -   4-Chloro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide,     -   3,4-Dichloro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide     -   N-4-[(6RS)-6-[(Ethylsulfonyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-(4-(6RS)-4—Oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide,     -   2-Fluoro-2-methyl-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)propanamide,     -   4-Fluoro-3-methoxy-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide,     -   N-4-[(6RS)-6-[(tert-Butylsulfonyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,N,6-trimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N,N-Diethyl-2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(Cyclopropylmethyl)-2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   2-Fluoro-2-methyl-N-4-[(6RS)-6-methyl-4-oxo-3-(phenylamino)-6-(pyrrolid         in-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylpropanamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(4-fluorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-2-yl}pyridin-2-yl)morpholine-4-carboxamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(3,4-dichlorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(4-chlorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-4-[(6RS)-6-[(4-Fluoro-3-methoxyphenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-4-[(6RS)-6-[(3,4-Difluorophenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   N-4-[(6RS)-6-[(4-Methoxyphenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide,     -   Methyl         (6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6-[(isopropylsulfanyl)methyl]-6-methyl-4,5,6,7-tetrahydro-4H-indol-4-one,     -   N-(4-{(6RS)-3-Anilino-4-oxo-6-[(1,3-thiazol-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(4-fluoro-3-hydroxyphenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(2-methoxyethyl)sulfonyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-{4-[(6RS)-3-Anilino-6-{[(4-fluorobenzyl)sulfonyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   (6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   tert-butyl         (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-N,N-dimethyl-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(2S)-2-hydroxypropyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-[(2R)-2-hydroxypropyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-[2-(pyrrolidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-methyl-N-[2-(morpholin-4-yl)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-cyclobutyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1         H-indol-6-carboxamide,     -   (6RS)-N-R²S)-1-methoxypropan-2-A-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-N-(1-methoxy-2-methylpropan-2-yl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   methyl         (6R)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   methyl         (6S)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6S)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6R)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6S)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6R)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide,     -   (6RS)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6R)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6S)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   N-{4-[(6RS)-6-(2-hydroxypropan-2-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1         H-indol-2-yl]pyridin-2-yl}acetamide,     -   N-{4-[(6RS)-6-(2-hydroxypropan-2-yl)-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide,     -   (6RS)-2-(3-fluoropyridin-4-yl)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-3-(phenylamino)-6-(prop-2-en-1-yl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-3-(phenylamino)-6-(prop-2-en-1-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-3-(phenylamino)-6-(prop-2-en-1-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-3-[(3-fluorophenyl)amino]-6-(hydroxymethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-{[4-(dimethylamino)piperidin-1-yl]methyl}-3-(phenylamino)-2-(pyridin-4-yl-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-6-[(4-methylpiperazin-1-yl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one,     -   4-fluoro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide,     -   N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-1,3-thiazole-5-carboxamide,     -   (1S,2S)-2-fluoro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}cyclopropanecarboxamide,     -   4-chloro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide,     -   3,4-dichloro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide,     -   (6RS)-6-(aminomethyl)-3-[(3-fluorophenyl)amino]-2-[3-(2-methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-indol-4-one,     -   (6RS)-N-({3-[(3-fluorophenyl)amino]-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl}methypacetamide,     -   methyl         (6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   methyl         (6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate,     -   (6RS)-2-(2-aminopyridin-4-yl)-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid,     -   (6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic,     -   (6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid hydrochloride,     -   (6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1         H-indol-6-carboxylic,     -   (6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic         acid hydrochloride, and     -   (6RS)-3-[(3-fluorophenyl)amino]-6-(hydroxymethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one,

or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

One special aspect of the invention is intermediate (17),

whereby R¹, R², A, and E have the meaning according to any one of claims 1 to 5 or as defined in the aspects and embodiments described herein.

One special aspect of the invention is intermediate (20),

whereby R¹, R², E have the meaning according to any one of claims 1 to 5 or as defined in the aspects and embodiments herein.

Another aspect of the invention relates to the use of any of the intermediates described herein for preparing a compound of formula (I) as defined herein or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹ represents hydrogen or C₁-C₆-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹ represents hydrogen or C₁-C₄-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹ represents hydrogen or C₁-C₂-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹ represents hydrogen or methyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹ represents hydrogen.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl             group is optionally substituted, one or more times,             independently from each other, with R⁴.     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl             group is optionally substituted, one or more times,             independently from each other, with R⁴,     -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted one,             two or three times, independently from each other, with             halogen, and optionally substituted one time with             R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is             optionally substituted, one or more times, independently             from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(CH₂)_(n)—;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl             group is optionally substituted, one or more times,             independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(CH₂)_(n)—;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is             optionally substituted, one or more times, independently             from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(CH₂)_(n)—;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             HO—C(O)—, (CH₃)₂N— or phenyl, wherein said phenyl group is             optionally substituted one, two or three times with fluoro.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             HO—C(O)—, (CH₃)₂N— or phenyl, wherein said phenyl group is             optionally substituted one, two or three times with F.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R² represents hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-;         -   wherein said C₂-C₄-alkenyl is optionally substituted with             one time with HO—C(O)—, (CH₃)₂N— or phenyl, wherein said             phenyl group is optionally substituted one, two or three             times with F.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R³ represents hydrogen or C₁-C₆-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R³ represents hydrogen or C₁-C₄-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R³ represents hydrogen, methyl or ethyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule and said group is optionally             substituted, one or more times, independently from each             other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   A represents a group selected from:

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   A represents a group selected from:

wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one or two times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R⁴ represents halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, C₁-C₄-hydroxyalkyl, C₁-C₄-alkyl-C(O)—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, C₁-C₄-alkyl-C(O)—NH—, R⁷R⁸N—, or R⁷R⁸N—SO₂—.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R⁴ represents halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, or C₁-C₄-haloalkoxy.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R⁴ represents halogen.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R⁴ represents fluoro or chloro.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   E represents a group

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁵ represents, independently from each other, halogen, hydroxy,         nitro, cyano, R⁹R¹⁰N—, (R¹³—C(O)—)(R¹⁴—C(O)—)N—, C₁-C₄-alkyl,         C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₄-haloalkyl,         C₁-C₆-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁶N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy,             C₃-C₆-cycloalkyl, and 4- to 6-membered heterocycloalkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁵ represents, independently from each other, halogen, hydroxy,         nitro, cyano, R⁹R¹⁰N—, (R¹³—C(O)—)(R¹⁴—C(O)—)N—, C₁-C₄-alkyl,         C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₄-haloalkyl,         C₁-C₆-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₆-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy,             C₃-C₆-cycloalkyl, and 4- to 6-membered heterocycloalkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁵ represents, independently from each other, halogen, hydroxy,         cyano, R⁹R¹⁰N—, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy,         R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₆-cycloalkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁵ represents, independently from each other, halogen, R⁹R¹⁰N—,         C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₄-alkoxy is optionally substituted, one or             more times, independently from each other, with a             substituent selected from hydroxy, C₁-C₄-alkoxy, and             C₃-C₄-cycloalkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁵ represents, independently from each other, fluoro, R⁹R¹⁰N—,         C₁-C₂-alkoxy, difluoroethoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—,         -   wherein said C₁-C₂-alkoxy is optionally substituted, one or             two times, independently from each other, with a substituent             selected from hydroxy, methoxy, and cyclopropyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   Q represents O or N—OH.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   Q represents O.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, nitro, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted,             one or more times, independently from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, nitro, cyano, C₁-C₆-alkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or             C₁-C₄-haloalkoxy.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,             C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted,             one or more times, independently from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkyl,             C₁-C₄-alkoxy, C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or             C₁-C₄-haloalkoxy.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or         heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁸N— or phenyl             optionally substituted, one or more times, independently             from each other, with R⁴,         -   wherein said C₃-C₆-cycloalkyl, 4- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, C₁-C₄-alkyl,             tert-butyl-O—C(O)—, or C₁-C₄-alkoxy.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁶ represents, independently from each other, C₁-C₆-alkyl,         C₃-C₄-cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or         5- to 6-membered heteroaryl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one, two             or three times, independently from each other, with fluoro,             hydroxy, methoxy, cyclopropyl, or R⁷R⁸N— and optionally             substituted one time with phenyl optionally substituted,             one, two or three times, independently from each other, with             R⁴,         -   wherein said C₃-C₄-cycloalkyl, 5- to 6-membered             heterocycloalkyl, phenyl or heteroaryl groups are optionally             substituted, one, two or three times, independently from             each other, with fluoro, chloro, hydroxy, methyl,             tert-butyl-O—C(O)—, or methoxy.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl             optionally substituted one time with hydroxy, 4- to             6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 7-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O, NR⁹ and S, and which may be         optionally substituted, one or more times, independently from         each other, with R¹²;         -   whereby when two R¹² substituents are attached to the same             ring carbon atom, together with the carbon atom to which             they are attached, can be linked to one another in such a             way that they jointly form a cyclobutane, azetidine, or             oxetane group;         -   said azetidine being optionally substituted one time with             C₁-C₃-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a group selected from :

-   -   -   wherein * indicates the point of attachment of said group             with the rest of the molecule.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl             optionally substituted one time with hydroxy, 4- to             6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one or             more times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 7-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O, NR⁹ and S, and which may be         optionally substituted, one or more times, independently from         each other, with R¹².

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₆-alkyl, C₃-C₄-cycloalkyl, tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,

wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or more times, independently from each other,         with R¹².

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₅-alkyl, cyclopropyl, tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one or             more times, independently from each other, with fluoro,             hydroxy, methoxy, C₃-C₄-cycloalkyl optionally substituted             one time with hydroxy, 5-membered heterocycloalkyl,             5-membered heteroaryl, or R⁹R¹⁹N—,         -   wherein said phenyl group is optionally substituted, one, or             two times, independently from each other, with fluoro or             chloro.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷, R⁸ represent, independently from each other, hydrogen,         C₁-C₅-alkyl, cyclopropyl, cyclobutyl, tert-butyl-O—C(O)— or         phenyl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one or             more times, independently from each other, with fluoro,             hydroxy, methoxy, C₃-C₄-cycloalkyl optionally substituted             one time with hydroxy, 5-membered heterocycloalkyl,             5-membered heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one, or             two times, independently from each other, with fluoro or             chloro.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ represents hydrogen, or C₁-C₆-alkyl,     -   R⁸ represents hydrogen, C₁-C₆-alkyl, C₃-C₄-cycloalkyl,         tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₆-alkyl is optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally             substituted one time with hydroxy, 4- to 6-membered             heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—,

wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ represents hydrogen, or C₁-C₅-alkyl,     -   R⁸ represents hydrogen, C₁-C₅-alkyl, cyclopropyl,         tert-butyl-O—C(O)— or phenyl,         -   wherein said C₁-C₅-alkyl is optionally substituted, one or             more times, independently from each other, with fluoro,             hydroxy, methoxy, C₃-C₄-cycloalkyl optionally substituted             one time with hydroxy, 5-membered heterocycloalkyl,             5-membered heteroaryl, or R⁹R¹⁰N—,         -   wherein said phenyl group is optionally substituted, one, or             two times, independently from each other, with fluoro or             chloro.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁷ and R⁸ together with the nitrogen atom to which they are         attached form a 4- to 6-membered nitrogen containing         heterocyclic ring, optionally containing one additional         heteroatom selected from O and NR⁹, and which may be optionally         substituted, one or two times, independently from each other,         with R¹².

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁹ represents hydrogen,or C₁-C₆-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁹ represents hydrogen or C₁-C₄-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁹ represents hydrogen or C₁C₂-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R⁹ represents hydrogen or methyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹⁰ represents hydrogen, C₁-C₆-alkyl or C₃-C₆-cycloalkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹⁰ represents hydrogen, C₁-C₄-alkyl, or C₃-C₄-cycloalkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹⁰ represents hydrogen or C₁-C₄-alkyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹° represents hydrogen or C₁-C₂-alkyl;

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹⁰ represents hydrogen or methyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹⁰ represents hydrogen, methyl or tert-butyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹¹ represents hydroxy, nitro, cyano, C₃-C₆-cycloalkyl, 4- to         6-membered heterocycloalkyl, C₁-C₄-alkyl-C(O)—, R¹⁰—O—C(O)—,         R⁷R⁸N—C(O)—, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R⁷R⁸N—, N₃—,         R⁶—C(O)—NR⁹—, R⁶—O—C(O)⁻NR⁹⁻, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—,         R⁶—S—, R⁶—SO—, R⁶—SO₂—, R⁷R⁸N—SO₂—;         -   wherein said C₃-C₆-cycloalkyl or 4- to 6-membered             heterocycloalkyl groups are optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkyl or             C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹¹ represents hydroxy, cyano, C₃-C₆-cycloalkyl, 4- to         6-membered heterocycloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy,         R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—,         R⁶—SO₂—NR⁹—, R⁶—S—, or R⁶—SO—, R⁶—SO₂—;         -   wherein said C₃-C₆-cycloalkyl or 4- to 6-membered             heterocycloalkyl groups are optionally substituted, one or             more times, independently from each other, with halogen,             hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl             or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹¹ represents hydroxy, 6-membered heterocycloalkyl,         C₁-C₂-alkoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—,         R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—;         -   wherein said 6-membered heterocycloalkyl group is optionally             substituted, one or more times, independently from each             other, with halogen, hydroxy, cyano, C₁-C₄-alkoxy,             C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy,         -   wherein said C₁-C₄-alkoxy is optionally substituted with             phenyl, wherein said phenyl group is optionally substituted,             one or more times, independently from each other, with R⁴

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹¹ represents hydroxy, morpholino, methoxy, R⁷R⁸N—, N₃—,         R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—,         R⁶—S—, or R⁶—SO₂—;         -   wherein said methoxy group is optionally substituted with             phenyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹¹ represents hydroxy, morpholino, methoxy, R⁷R⁸N—, N₃—,         R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—,         R⁶—S—, R⁶—SO—, or R⁶—SO₂—;         -   wherein said methoxy group is optionally substituted with             phenyl.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R¹² represents halogen, hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, or R⁹R¹⁰N—.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R¹² represents halogen, hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, or R⁹R¹⁰N—.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

R¹² represents halogen, hydroxy, C₁-C₂-alkyl, R⁹R¹⁰N—.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹² represents fluoro, hydroxy, methyl, or R⁹R¹⁰N—.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   R¹³, R¹⁴ represent, independently from each other, C₁-C₄-alkyl,         or C₃-C₆-cycloalkyl,         -   wherein said C₃-C₆-cycloalkyl is optionally substituted, one             or more times, independently from each other, with halogen.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   m represents 0, 1 or 2.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   m represents 0, or 1.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   n represents 1, 2, 3 or 4.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I), wherein:

-   -   n represents 1 or 4.

In a further embodiment of the above-mentioned aspects, the invention relates to compounds of formula (I) as described herein, with the proviso that the compound of formula (I) is not

(6RS)-6-(Hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

One aspect of the invention are compounds of formula (I) as described in the examples, as characterized by their names in the title, as claimed in claims 1 to 5, and their structures as well as the subcombinations of all residues specifically disclosed in the compounds of the examples.

Another aspect of the present invention are the intermediates as used for their synthesis.

A further aspect of the invention are compounds according to the invention, which are present as their salts.

It is to be understood that the present invention relates to any sub-combination within any embodiment or aspect of the present invention of compounds of formula (I) according to the invention, supra.

More particularly still, the present invention covers compounds of formula (I) according to the invention which are disclosed in the Example section of this text, infra.

In accordance with another aspect, the present invention covers methods of preparing compounds of formula (I) of the present invention, said methods comprising the steps as described in the Experimental Section herein.

Another embodiment of the invention are compounds according to the claims as disclosed in the Claims section wherein the definitions are limited according to the preferred or more preferred definitions as disclosed below or specifically disclosed residues of the exemplified compounds and subcombinations thereof.

Definitions

Constituents which are optionally substituted as stated herein, may be substiuted, unless otherwise noted, one or more times, independently from one another at any possible position. When any variable occurs more than one time in any constituent, each definition is independent. For example, when R¹, R², R³, R⁴, R⁵, R⁶, R^(6a),R⁷, R⁸, R^(7a), R^(8a), R⁹, R¹⁰, R¹¹, R¹², R^(13,) and/or R¹⁴, occur more than one time in any compound of formula (I) each definition of R¹, R², R³, R⁴, R⁵, R⁶, R^(6a), R⁷, R⁸, R^(7a), R^(8a), R⁹, R¹⁰, R¹¹, R¹², R¹³, and R¹⁴ is independent.

Should a constituent be composed of more than one part, e.g. C₁-C₄-alkoxy-C₁-C₄-alkyl-, the position of a possible substituent can be at any of these parts at any suitable position.

A hyphen at the beginning of the constituent marks the point of attachment with the rest of the molecule. Should a ring be substituted the substitutent could be at any suitable position of the ring, also on a ring nitrogen atom if suitable, unless indicated otherwise.

The term “comprising” when used in the specification includes “consisting of”.

If it is referred to “as mentioned above” or “mentioned above” within the description it is referred to any of the disclosures made within the specification in any of the preceding pages.

“suitable” within the sense of the invention means chemically possible to be made by methods within the knowledge of a skilled person.

The terms as mentioned in the present text have preferably the following meanings:

The term “halogen atom”, “halo-” or “Hal-” is to be understood as meaning a fluorine, chlorine, bromine or iodine atom, preferably a fluorine, chlorine, bromine or iodine atom.

The term “C₁-C₆-alkyl” is to be understood as preferably meaning a linear or branched, saturated, monovalent hydrocarbon group having 1, 2, 3, 4,5 or carbon atoms, e.g. a methyl, ethyl, propyl, butyl, pentyl, hexyl, iso-propyl, iso-butyl, sec-butyl, tert-butyl, iso-pentyl, 2-methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, neo-pentyl, 1,1-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethylbutyl, 1-ethylbutyl, 3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 2,3-dimethylbutyl, 1,3-dimethylbutyl or 1,2-dimethylbutyl group, or an isomer thereof, particularly 1, 2, 3 or 4 carbon atoms (“C₁-C₄-alkyl”), e.g. a methyl, ethyl, propyl, butyl, iso-propyl, iso-butyl, sec-butyl, tert-butyl group, more particularly 1, 2, or 3 carbon atoms (“C₁-C₃-alkyl”) e.g. a methyl, ethyl, n-propyl- or iso-propyl group.

The term “C₂-C₄-alkenyl” is to be understood as meaning a linear or branched, monovalent hydrocarbon group, which contains one or two double bonds, and which has 2, 3 or 4 carbon atoms, particularly 2 or 3 carbon atoms (“C₂-C₃-alkenyl”), it being understood that in the case in which said alkenyl group contains more than one double bond, then said double bonds may be isolated from, or conjugated with, each other. Said alkenyl group is, for example, a vinyl, allyl, (E)-2-methylvinyl, (Z)-2-methylvinyl, homoallyl, (E)-but-2-enyl, (Z)-but-2-enyl, (E)-but-1-enyl, (Z)-but-1-enyl, iso-propenyl, 2-methylprop-2-enyl, 1-methylprop-2-enyl, 2-methylprop-1-enyl, (E)-1-methylprop-1-enyl, (Z)-1-methylprop-1-enyl, or buta-1,3-dienyl group. Particularly, said group is vinyl or allyl.

The term “C₁-C₄-haloalkyl” is to be understood as preferably meaning a linear or branched, saturated, monovalent hydrocarbon group in which the term “C₁-C₄-alkyl” is defined supra, and in which one or more hydrogen atoms is replaced by a halogen atom, in identically or differently, i.e. one halogen atom being independent from another. Particularly, said halogen atom is F. Said C₁-C₄-haloalkyl group is, for example, —CF₃, —CHF₂, —CH₂F, —CF₂CF₃, or—CH₂CF₃.

The term “C₁-C₆-alkoxy” is to be understood as preferably meaning a linear or branched, saturated, monovalent, hydrocarbon group of formula-O-alkyl, in which the term “alkyl” is defined supra, e.g. a methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, tert-butoxy or sec-butoxy group, or an isomer thereof.

The term “C₁-C₆-haloalkoxy” is to be understood as preferably meaning a linear or branched, saturated, monovalent C₁-C₄-alkoxy group, as defined supra, in which one or more of the hydrogen atoms is replaced, in identically or differently, by a halogen atom. Particularly, said halogen atom is F. Said C₁-C₆-haloalkoxy group is, for example, —OCF₃, —OCHF₂, —OCH₂F, —OCF₂CF₃, or —OCH₂CF₃.

The term “C₃-C₆-cycloalkyl” is to be understood as meaning a saturated, monovalent, mono-, or bicyclic hydrocarbon ring which contains 3, 4,5 or 6 carbon atoms (“C₃-C₆-cycloalkyl”). Said C₃-C₆-cycloalkyl group is for example, a monocyclic hydrocarbon ring, e.g. a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, or a bicyclic hydrocarbon ring.

The term “heteroaryl” is understood as meaning a monovalent, monocyclic, aromatic ring system having 5, or 6, ring atoms (a “5- to 6-membered heteroaryl” group), which contains at least one ring heteroatom atom and optionally one, two or three further ring heteroatoms from the series N, NR¹⁰, O and/or S, and which is bound via a ring carbon atom or, unless otherwise defined, optionally via a ring nitrogen atom (when allowed by valency). R¹⁰ is as defined herein. Optionally, said 5- to 6-membered heteroaryl can be fused with a benzene ring (benzofused). Preferred heteroaryl benzofused groups include, but are not limited to, 1,3-Benzothiazolyl.

Said heteroaryl group can be a 5-membered heteroaryl group, such as, for example, thienyl, furanyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl or tetrazolyl; or a 6-membered heteroaryl group, such as, for example, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl. In general, and unless otherwise mentioned, the heteroarylic or heteroarylenic radicals include all the possible isomeric forms thereof, e.g.: tautomers and positional isomers with respect to the point of linkage to the rest of the molecule. Thus, for some illustrative non-restricting example, the term pyridinyl includes pyridin-2-yl, pyridin-3-yl and pyridin-4-yl; or the term thienyl includes thien-2-yl and thien-3-yl.

The term “4- to 7-membered heterocycloalkyl” or “4- to 7-membered heterocyclic ring”, is to be understood as meaning a saturated or partially unsaturated, monovalent, mono- or bicyclic hydrocarbon ring which contains 3, 4,5 or 6, carbon atoms, and one or more heteroatom-containing groups selected from O, S, S(═O), S(═0)₂, and NR¹⁰, in which R¹⁰ is as defined herein; optionally one ring carbon atom is replaced with a C(═O) group, it being possible for said heterocycloalkyl group to be attached to the rest of the molecule via any one of the carbon atoms or, if present, the nitrogen atom.

Particularly, said 4- to 7-membered heterocycloalkyl can contain 3, 4, or 5 carbon atoms, and one or more of the above-mentioned heteroatom-containing groups (a “4- to 6-membered heterocycloalkyl”), more particularly said heterocycloalkyl can contain 4 or 5 carbon atoms, and one or more of the above-mentioned heteroatom-containing groups (a “5- to 6-membered heterocycloalkyl”).

Particularly, without being limited thereto, said heterocycloalkyl can be a 4-membered ring, such as an azetidinyl, oxetanyl, or a 5-membered ring, such as tetrahydrofuranyl, dioxolinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, pyrrolinyl, or a 6-membered ring, such as tetrahydropyranyl, piperidinyl, morpholinyl, dithianyl, thiomorpholinyl, piperazinyl, or trithianyl, or a 7-membered ring, such as a diazepanyl ring, for example. Optionally, said heterocycloalkyl can be benfused.

Said heterocyclyl can be bicyclic, such as, without being limited thereto, a 5,5-membered ring, e.g. a hexahydrocyclopenta[c]pyrrol-2(1H)-yl ring, or a 5,6-membered bicyclic ring, e.g. a hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl ring.

As mentioned supra, said nitrogen atom-containing ring can be partially unsaturated, i.e. it can contain one or more double bonds, such as, without being limited thereto, a 2,5-dihydro-1H-pyrrolyl, 4H-[1,3,4]thiadiazinyl, 4,5-dihydrooxazolyl, or 4H-[1,4]thiazinyl ring, for example, or, it may be benzo-fused, such as, without being limited thereto, a dihydroisoquinolinyl ring, for example.

The term “C₁-C₆”, as used throughout this text, e.g. in the context of the definition of “C₁-C₆-alkyl” or “C₁-C₆-alkoxy” is to be understood as meaning an alkyl group having a finite number of carbon atoms of 1 to 6, i.e. 1, 2, 3, 4,5, or 6 carbon atoms. It is to be understood further that said term “C₁-C₆” is to be interpreted as any sub-range comprised therein, e.g. C₁-C₆, C₂-C₅, C₃-C₄, C₁-C₂, C₁-C₃, C₁-C₄, C₁-C₅, C₁-C₆, particularly C₁-C₂, C₁-C₃, C₁-C₄, C₁-C₅, C₁-C₆ more particularly C₁-C_(4;) in the case of “C₁-C₆-haloalkyl” or “C₁-C₆-haloalkoxy” even more particularly C₁-C₂.

Further, as used herein, the term “C₃-C₆”, as used throughout this text, e.g. in the context of the definition of “C₃-C₆-cycloalkyl”, is to be understood as meaning a cycloalkyl group having a finite number of carbon atoms of 3 to 6, i.e. 3, 4,5 or 6 carbon atoms. It is to be understood further that said term “C₃-C₆” is to be interpreted as any sub-range comprised therein, e.g. C₃-C₆, C₄-C₅, C₃-C₅, C₃-C₄, C₄-C_(6,) C₅-C₆; particularly C₃-C₆.

The term “substituted” means that one or more hydrogens on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency under the existing circumstances is not exceeded, and that the substitution results in a stable compound. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds.

The term “optionally substituted” means optional substitution with the specified groups, radicals or moieties.

Ring system substituent means a substituent attached to an aromatic or nonaromatic ring system which, for example, replaces an available hydrogen on the ring system.

As used herein, the term “one or more”, e.g. in the definition of the substituents of the compounds of the general formulae of the present invention, is understood as meaning “one, two, three, four or five, particularly one, two, three or four, more particularly one, two or three, even more particularly one or two”.

The invention also includes all suitable isotopic variations of a compound of the invention. An isotopic variation of a compound of the invention is defined as one in which at least one atom is replaced by an atom having the same atomic number but an atomic mass different from the atomic mass usually or predominantly found in nature. Examples of isotopes that can be incorporated into a compound of the invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulphur, fluorine, chlorine, bromine and iodine, such as ²H (deuterium), ³H (tritium), ¹¹C, ¹³C, ¹⁴C, ¹⁵N, ¹⁷O, ¹⁸O, ³²P, ³³P, ³³S, ³⁴S, ³⁵S, ³⁶S, ¹⁸F, ³⁶Cl, ₈₂Br, ¹²³I, ¹²⁴I , ¹²⁹I and ¹³¹I, respectively . Certain isotopic variations of a compound of the invention, for example, those in which one or more radioactive isotopes such as ³H or ¹⁴C are incorporated, are useful in drug and/or substrate tissue distribution studies. Tritiated and carbon-14, i.e., ¹⁴C, isotopes are particularly preferred for their ease of preparation and detectability. Further, substitution with isotopes such as deuterium may afford certain therapeutic advantages resulting from greater metabolic stability, for example, increased in vivo half-life or reduced dosage requirements and hence may be preferred in some circumstances. Isotopic variations of a compound of the invention can generally be prepared by conventional procedures known by a person skilled in the art such as by the illustrative methods or by the preparations described in the examples hereafter using appropriate isotopic variations of suitable reagents.

Where the plural form of the word compounds, salts, polymorphs, hydrates, solvates and the like, is used herein, this is taken to mean also a single compound, salt, polymorph, isomer, hydrate, solvate or the like.

By “stable compound' or “stable structure” is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent.

The compounds of this invention may contain one or more asymmetric centre, depending upon the location and nature of the various substituents desired. Asymmetric carbon atoms may be present in the (R) or (S) configuration, resulting in racemic mixtures in the case of a single asymmetric centre, and diastereomeric mixtures in the case of multiple asymmetric centres. In certain instances, asymmetry may also be present due to restricted rotation about a given bond, for example, the central bond adjoining two substituted aromatic rings of the specified compounds. Substituents on a ring may also be present in either cis or trans form. It is intended that all such configurations (including enantiomers and diastereomers), are included within the scope of the present invention.

Preferred compounds are those which produce the more desirable biological activity. Separated, pure or partially purified isomers and stereoisomers or racemic or diastereomeric mixtures of the compounds of this invention are also included within the scope of the present invention. The purification and the separation of such materials can be accomplished by standard techniques known in the art.

The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, for example, by the formation of diastereoisomeric salts using an optically active acid or base or formation of covalent diastereomers. Examples of appropriate acids are tartaric, diacetyltartaric, ditoluoyltartaric and camphorsulfonic acid. Mixtures of diastereoisomers can be separated into their individual diastereomers on the basis of their physical and/or chemical differences by methods known in the art, for example, by chromatography or fractional crystallisation. The optically active bases or acids are then liberated from the separated diastereomeric salts. A different process for separation of optical isomers involves the use of chiral chromatography (e.g., chiral HPLC columns), with or without conventional derivatisation, optimally chosen to maximise the separation of the enantiomers. Suitable chiral HPLC columns are manufactured by Daicel, e.g., Chiracel OD and Chiracel OJ among many others, all routinely selectable. Enzymatic separations, with or without derivatisation, are also useful. The optically active compounds of this invention can likewise be obtained by chiral syntheses utilizing optically active starting materials.

In order to limit different types of isomers from each other reference is made to IUPAC Rules Section E (Pure Appl Chem 45, 11-30, 1976).

The present invention includes all possible stereoisomers of the compounds of the present invention as single stereoisomers, or as any mixture of said stereoisomers, e.g. R- or S-isomers, or E- or Z-isomers, in any ratio. Isolation of a single stereoisomer, e.g. a single enantiomer or a single diastereomer, of a compound of the present invention may be achieved by any suitable state of the art method, such as chromatography, especially chiral chromatography, for example.

Further, the compounds of the present invention may exist as tautomers. For example, any compound of the present invention which contains a pyrazole moiety as a heteroaryl group for example can exist as a 1H tautomer, or a 2H tautomer, or even a mixture in any amount of the two tautomers, or a triazole moiety for example can exist as a 1H tautomer, a 2H tautomer, or a 4H tautomer, or even a mixture in any amount of said 1H, 2H and 4H tautomers, namely :

The present invention includes all possible tautomers of the compounds of the present invention as single tautomers, or as any mixture of said tautomers, in any ratio.

Further, the compounds of the present invention can exist as N-oxides, which are defined in that at least one nitrogen of the compounds of the present invention is oxidised. The present invention includes all such possible N-oxides.

The present invention also relates to useful forms of the compounds as disclosed herein, such as metabolites, hydrates, solvates, prodrugs, salts, in particular pharmaceutically acceptable salts, and co-precipitates.

The compounds of the present invention can exist as a hydrate, or as a solvate, wherein the compounds of the present invention contain polar solvents, in particular water, methanol or ethanol for example as structural element of the crystal lattice of the compounds. The amount of polar solvents, in particular water, may exist in a stoichiometric or non-stoichiometric ratio. In the case of stoichiometric solvates, e.g. a hydrate, hemi-, (semi-), mono-, sesqui-, di-, tri-, tetra-, penta- etc. solvates or hydrates, respectively, are possible. The present invention includes all such hydrates or solvates.

Further, the compounds of the present invention can exist in free form, e.g. as a free base, or as a free acid, or as a zwitterion, or can exist in the form of a salt. Said salt may be any salt, either an organic or inorganic addition salt, particularly any pharmaceutically acceptable organic or inorganic addition salt, customarily used in pharmacy.

The term “pharmaceutically acceptable salt” refers to a relatively non-toxic, inorganic or organic acid addition salt of a compound of the present invention. For example, see S. M. Berge, et al. “Pharmaceutical Salts,” J. Pharm. Sci. 1977, 66, 1-19.

A suitable pharmaceutically acceptable salt of the compounds of the present invention may be, for example, an acid-addition salt of a compound of the present invention bearing a nitrogen atom, in a chain or in a ring, for example, which is sufficiently basic, such as an acid-addition salt with an inorganic acid, such as hydrochloric, hydrobromic, hydroiodic, sulfuric, bisulfuric, phosphoric, or nitric acid, for example, or with an organic acid, such as formic, acetic, acetoacetic, pyruvic, trifluoroacetic, propionic, butyric, hexanoic, heptanoic, undecanoic, lauric, benzoic, salicylic, 2-(4-hydroxybenzoyl)-benzoic, camphoric, cinnamic, cyclopentanepropionic, digluconic, 3-hydroxy-2-naphthoic, nicotinic, pamoic, pectinic, persulfuric, 3-phenylpropionic, picric, pivalic, 2-hydroxyethanesulfonate, itaconic, sulfamic, trifluoromethanesulfonic, dodecylsulfuric, ethansulfonic, benzenesulfonic, para-toluenesulfonic, methansulfonic, 2-naphthalenesulfonic, naphthalinedisulfonic, camphorsulfonic acid, citric, tartaric, stearic, lactic, oxalic, malonic, succinic, malic, adipic, alginic, maleic, fumaric, D-gluconic, mandelic, ascorbic, glucoheptanoic, glycerophosphoric, aspartic, sulfosalicylic, hemisulfuric, or thiocyanic acid, for example.

Further, another suitably pharmaceutically acceptable salt of a compound of the present invention which is sufficiently acidic, is an alkali metal salt, for example a sodium or potassium salt, an alkaline earth metal salt, for example a calcium or magnesium salt, an ammonium salt or a salt with an organic base which affords a physiologically acceptable cation, for example a salt with N-methyl-glucamine, dimethyl-glucamine, ethyl-glucamine, lysine, dicyclohexylamine, 1,6-hexadiamine, ethanolamine, glucosamine, sarcosine, serinol, tris-hydroxy-methyl-aminomethane, aminopropandiol, sovak-base, 1-amino-2,3,4-butantriol. Additionally, basic nitrogen containing groups may be quaternised with such agents as lower alkyl halides such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, and dibutyl sulfate; and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and strearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phemethyl bromides and others.

Those skilled in the art will further recognise that acid addition salts of the claimed compounds may be prepared by reaction of the compounds with the appropriate inorganic or organic acid via any of a number of known methods. Alternatively, alkali and alkaline earth metal salts of acidic compounds of the invention are prepared by reacting the compounds of the invention with the appropriate base via a variety of known methods.

The present invention includes all possible salts of the compounds of the present invention as single salts, or as any mixture of said salts, in any ratio.

In the present text, in particular in the Experimental Section, for the synthesis of intermediates and of examples of the present invention, when a compound is mentioned as a salt form with the corresponding base or acid, the exact stoichiometric composition of said salt form, as obtained by the respective preparation and/or purification process, is, in most cases, unknown.

Unless specified otherwise, suffixes to chemical names or structural formulae such as “hydrochloride”, “trifluoroacetate”, “sodium salt”, or “x HCl”, “x CF3COOH”, “x Na+”, for example, are to be understood as not a stoichiometric specification, but solely as a salt form.

This applies analogously to cases in which synthesis intermediates or example compounds or salts thereof have been obtained, by the preparation and/or purification processes described, as solvates, such as hydrates with (if defined) unknown stoichiometric composition.

The salts include water-insoluble and, particularly, water-soluble salts.

Furthermore, derivatives of the compounds according to the invention and the salts thereof which are converted into a compound according to the invention or a salt thereof in a biological system (bioprecursors or pro-drugs) are covered by the invention. Said biological system is e.g. a mammalian organism, particularly a human subject. The bioprecursor is, for example, converted into the compound according to the invention or a salt thereof by metabolic processes.

As used herein, the term “in vivo hydrolysable ester” is understood as meaning an in vivo hydrolysable ester of a compound of the present invention containing a carboxy or hydroxy group, for example, a pharmaceutically acceptable ester which is hydrolysed in the human or animal body to produce the parent acid or alcohol. Suitable pharmaceutically acceptable esters for carboxy include for example alkyl, cycloalkyl and optionally substituted phenylalkyl, in particular benzyl esters, C₁-C₆ alkoxymethyl esters, e.g. methoxymethyl, C₁-C₆ alkanoyloxymethyl esters, e.g. pivaloyloxymethyl, phthalidyl esters, C₃-C₈ cycloalkoxy-carbonyloxy-C₁-C₆ alkyl esters, e.g. 1-cyclohexylcarbonyloxyethyl; 1,3-dioxolen-2-onylmethyl esters, e.g. 5-methyl-1,3-dioxolen-2-onylmethyl; and C₁-C₆-alkoxycarbonyloxyethyl esters, e.g. 1-methoxycarbonyloxyethyl, and may be formed at any carboxy group in the compounds of this invention. An in vivo hydrolysable ester of a compound of the present invention containing a hydroxy group includes inorganic esters such as phosphate esters and [alpha]-acyloxyalkyl ethers and related compounds which as a result of the in vivo hydrolysis of the ester breakdown to give the parent hydroxy group. Examples of [alpha]-acyloxyalkyl ethers include acetoxymethoxy and 2,2-dimethylpropionyloxymethoxy. A selection of in vivo hydrolysable ester forming groups for hydroxy include alkanoyl, benzoyl, phenylacetyl and substituted benzoyl and phenylacetyl, alkoxycarbonyl (to give alkyl carbonate esters), dialkylcarbamoyl and N-(dialkylaminoethyl)-N-alkylcarbamoyl (to give carbamates), dialkylaminoacetyl and carboxyacetyl. The present invention covers all such esters.

Furthermore, the present invention includes all possible crystalline forms, or polymorphs, of the compounds of the present invention, either as single polymorphs, or as a mixture of more than one polymorphs, in any ratio.

In the context of the properties of the compounds of the present invention the term “pharmacokinetic profile” means one single parameter or a combination thereof including permeability, bioavailability, exposure, and pharmacodynamic parameters such as duration, or magnitude of pharmacological effect, as measured in a suitable experiment. Compounds with improved pharmacokinetic profiles can, for example, be used in lower doses to achieve the same effect, may achieve a longer duration of action, or a may achieve a combination of both effects.

The term “combination” in the present invention is used as known to persons skilled in the art and may be present as a fixed combination, a non-fixed combination or kit-of-parts.

A “fixed combination” in the present invention is used as known to persons skilled in the art and is defined as a combination wherein the said first active ingredient and the said second active ingredient are present together in one unit dosage or in a single entity. One example of a “fixed combination” is a pharmaceutical composition wherein the said first active ingredient and the said second active ingredient are present in admixture for simultaneous administration, such as in a formulation. Another example of a “fixed combination” is a pharmaceutical combination wherein the said first active ingredient and the said second active ingredient are present in one unit without being in admixture.

A non-fixed combination or “kit-of-parts” in the present invention is used as known to persons skilled in the art and is defined as a combination wherein the said first active ingredient and the said second active ingredient are present in more than one unit. One example of a non-fixed combination or kit-of-parts is a combination wherein the said first active ingredient and the said second active ingredient are present separately. The components of the non-fixed combination or kit-of-parts may be administered separately, sequentially, simultaneously, concurrently or chronologically staggered. Any such combination of a compound of the present invention with an anti-cancer agent as defined below is an embodiment of the invention.

The term “(chemotherapeutic) anti-cancer agents”, includes but is not limited to: 131I-chTNT, abarelix, abiraterone, aclarubicin, ado-trastuzumab emtansine, afatinib, aflibercept, aldesleukin, alectinib, alemtuzumab, alendronic acid, alitretinoin, altretamine, amifostine, aminoglutethimide, hexyl aminolevulinate, amrubicin, amsacrine, anastrozole, ancestim, anethole dithiolethione, anetumab ravtansine, angiotensin II, antithrombin III, aprepitant, arcitumomab, arglabin, arsenic trioxide, asparaginase, axitinib, azacitidine, basiliximab, belotecan, bendamustine, besilesomab, belinostat, bevacizumab, bexarotene, bicalutamide, bisantrene, bleomycin, blinatumomab, bortezomib, buserelin, bosutinib, brentuximab vedotin, busulfan, cabazitaxel, cabozantinib, calcitonine, calcium folinate, calcium levofolinate, capecitabine, capromab, carboplatin, carboquone, carfilzomib, carmofur, carmustine, catumaxomab, celecoxib, celmoleukin, ceritinib, cetuximab, chlorambucil, chlormadinone, chlormethine, cidofovir, cinacalcet, cisplatin, cladribine, clodronic acid, clofarabine, cobimetinib, copanlisib , crisantaspase, crizotinib, cyclophosphamide, cyproterone, cytarabine, dacarbazine, dactinomycin, daratumumab, darbepoetin alfa, dabrafenib, dasatinib, daunorubicin, decitabine, degarelix, denileukin diftitox, denosumab, depreotide, deslorelin, dianhydrogalactitol, dexrazoxane, dibrospidium chloride, dianhydrogalactitol, diclofenac, dinutuximab, docetaxel, dolasetron, doxifluridine, doxorubicin, doxorubicin+estrone, dronabinol, eculizumab, edrecolomab, elliptinium acetate, elotuzumab, eltrombopag, endostatin, enocitabine, enzalutamide, epirubicin, epitiostanol, epoetin alfa, epoetin beta, epoetin zeta, eptaplatin, eribulin, erlotinib, esomeprazole, estradiol, estramustine, ethinylestradiol, etoposide, everolimus, exemestane, fadrozole, fentanyl, filgrastim, fluoxymesterone, floxuridine, fludarabine, fluorouracil, flutamide, folinic acid, formestane, fosaprepitant, fotemustine, fulvestrant, gadobutrol, gadoteridol, gadoteric acid meglumine, gadoversetamide, gadoxetic acid, gallium nitrate, ganirelix, gefitinib, gemcitabine, gemtuzumab, Glucarpidase, glutoxim, GM-CSF, goserelin, granisetron, granulocyte colony stimulating factor, histamine dihydrochloride, histrelin, hydroxycarbamide, 1-125 seeds, lansoprazole, ibandronic acid, ibritumomab tiuxetan, ibrutinib, idarubicin, ifosfamide, imatinib, imiquimod, improsulfan, indisetron, incadronic acid, ingenol mebutate, interferon alfa, interferon beta, interferon gamma, iobitridol, iobenguane (123I), iomeprol, ipilimumab, irinotecan, Itraconazole, ixabepilone, ixazomib, lanreotide, lansoprazole, lapatinib, lasocholine, lenalidomide, lenvatinib, lenograstim, lentinan, letrozole, leuprorelin, levamisole, levonorgestrel, levothyroxine sodium, lisuride, lobaplatin, lomustine, lonidamine, masoprocol, medroxyprogesterone, megestrol, melarsoprol, melphalan, mepitiostane, mercaptopurine, mesna, methadone, methotrexate, methoxsalen, methylaminolevulinate, methylprednisolone, methyltestosterone, metirosine, mifamurtide, miltefosine, miriplatin, mitobronitol, mitoguazone, mitolactol, mitomycin, mitotane, mitoxantrone, mogamulizumab, molgramostim, mopidamol, morphine hydrochloride, morphine sulfate, nabilone, nabiximols, nafarelin, naloxone+pentazocine, naltrexone, nartograstim, necitumumab, nedaplatin, nelarabine, neridronic acid, netupitant/palonosetron, nivolumabpentetreotide, nilotinib, nilutamide, nimorazole, nimotuzumab, nimustine, nintedanib, nitracrine, nivolumab, obinutuzumab, octreotide, ofatumumab, olaparib, omacetaxine mepesuccinate, omeprazole, ondansetron, oprelvekin, orgotein, orilotimod, osimertinib, oxaliplatin, oxycodone, oxymetholone, ozogamicine, p53 gene therapy, paclitaxel, palbociclib, palifermin, palladium-103 seed, palonosetron, pamidronic acid, panitumumab, panobinostat, pantoprazole, pazopanib, pegaspargase, PEG-epoetin beta (methoxy PEG-epoetin beta), pembrolizumab, pegfilgrastim, peg interferon alfa-2b, pemetrexed, pentazocine, pentostatin, peplomycin, Perflubutane, perfosfamide, Pertuzumab, picibanil, pilocarpine, pirarubicin, pixantrone, plerixafor, plicamycin, poliglusam, polyestradiol phosphate, polyvinylpyrrolidone+sodium hyaluronate, polysaccharide-K, pomalidomide, ponatinib, porfimer sodium, pralatrexate, prednimustine, prednisone, procarbazine, procodazole, propranolol, quinagolide, rabeprazole, racotumomab, radium-223 chloride, radotinib, raloxifene, raltitrexed, ramosetron, ramucirumab, ranimustine, rasburicase, razoxane, refametinib , regorafenib, risedronic acid, rhenium-186 etidronate, rituximab, rolapitant, romidepsin, romiplostim, romurtide, roniciclib, samarium (153Sm) lexidronam, sargramostim, satumomab, secretin, siltuximab, sipuleucel-T, sizofiran, sobuzoxane, sodium glycididazole, sonidegib, sorafenib, stanozolol, streptozocin, sunitinib, talaporfin, talimogene laherparepvec, tamibarotene, tamoxifen, tapentadol, tasonermin, teceleukin, technetium (99mTc) nofetumomab merpentan, 99mTc-HYNIC-[Tyr3]-octreotide, tegafur, tegafur+gimeracil+oteracil, temoporfin, temozolomide, temsirolimus, teniposide, testosterone, tetrofosmin, thalidomide, thiotepa, thymalfasin, thyrotropin alfa, tioguanine, tocilizumab, topotecan, toremifene, tositumomab, trabectedin, trametinib, tramadol, trastuzumab, trastuzumab emtansine, treosulfan, tretinoin, trifluridine+tipiracil, trilostane, triptorelin, trametinib, trofosfamide, thrombopoietin, tryptophan, ubenimex, valatinib , valrubicin, vandetanib, vapreotide, vemurafenib, vinblastine, vincristine, vindesine, vinflunine, vinorelbine, vismodegib, vorinostat, vorozole, yttrium-90 glass microspheres, zinostatin, zinostatin stimalamer, zoledronic acid, zorubicin.

It has now been found, and this constitutes the basis of the present invention, that said compounds of the present invention have surprising and advantageous properties.

In particular, said compounds of the present invention have surprisingly been found to effectively inhibit Bubl kinase and may therefore be used for the treatment or prophylaxis of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses or diseases which are accompanied with uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses, particularly in which the uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses is mediated by Bub1 kinase, such as, for example, haematological tumours, solid tumours, and/or metastases thereof, e.g. leukaemias and myelodysplastic syndrome, malignant lymphomas, head and neck tumours including brain tumours and brain metastases, tumours of the thorax including non-small cell and small cell lung tumours, gastrointestinal tumours, endocrine tumours, mammary and other gynaecological tumours, urological tumours including renal, bladder and prostate tumours, skin tumours, and sarcomas, and/or metastases thereof.

The intermediates used for the synthesis of the compounds of the claims as described below, as well as their use for the synthesis of the compounds of claims described below, are one further aspect of the present invention. Preferred intermediates are the Intermediate Examples as disclosed below.

General Procedures

The compounds according to the invention can be prepared according to the following Schemes 1-19.

The Schemes and procedures described below illustrate synthetic routes to the compounds of general formula (I) of the invention and are not intended to be limiting. It is obvious to the person skilled in the art that the order of transformations as exemplified in the Schemes can be modified in various ways. The order of transformations exemplified in the Schemes is therefore not intended to be limiting. In addition, interconversion of any of the substituents, R¹, R², R³, A and E can be achieved before and/or after the exemplified transformations. These modifications can be such as the introduction of protecting groups, cleavage of protecting groups, reduction or oxidation of functional groups, halogenation, metallation, substitution or other reactions known to the person skilled in the art. These transformations include those which introduce a functionality which allows for further interconversion of substituents. Appropriate protecting groups and their introduction and cleavage are well-known to the person skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3^(rd) edition, Wiley 1999). Specific examples are described in the subsequent paragraphs.

Scheme 1 Process for the preparation of reagents A, wherein R¹ and R² have the meaning as given for general formula (I) and whereby X¹ is a leaving group, such as, for example, F, Cl, Br, I or aryl sulfonate such as for example p-toluene sulfonate, or alkyl sulfonate such as for example methane sulfonate or trifluoromethane sulfonate, are commercially available or can be synthesized by those skilled in the art. Compounds of general formula (1) can be converted to compounds of general formula (2) by reduction methods, such as for example, the Birch reduction using either sodium or lithium in liquid ammonia, in a temperature range from -78° C. to room temperature, to furnish general formula (2). Compounds of general formula (2) can be converted to compounds of general formula (3) using primarily alkylation methods which known to those skilled and are available in the public domain (see the teachings of Bannwarth et al., Bioorg. Med. Chem. Lett., 1996, 6, 1525 and Bandara et al., J. Chem. Soc., Perkin Trans 1, 1982, 1755) to furnish general formula (3). Compounds of general formula (2) and/or compounds of general formula (3) can be converted to reagents A, such as for example, using acidic hydrolysis methods which known to those skilled and are available in the public domain (see the teachings of Bannwarth et al., Bioorg. Med. Chem. Lett., 1996, 6, 1525 and Bandara et al., J. Chem. Soc., Perkin Trans 1, 1982, 1755) to furnish Reagent A. Similar such transformations for the preparation of reagents A have been previously reported (EP2617720 A1; WO 2010/46194 A; Austin et al., J. Am. Chem. Soc., 1997, 119, 6461).

Scheme 2 Another process for the preparation of reagents A, wherein R¹ and R² have the meaning as given for general formula (I). Compounds of general formula (4) can be converted to compounds of general formula (5) or general formula (6) by alkylation methods using, such as for example, alkyl esters of malonic acid , such as, for example, dimethyl malonate or diethyl malonate, under basic conditions to give either general formula (5) or general formula (6). Alternatively, general formula (5) can be isolated and converted to general formula (6) using basic conditions. Compounds of general formula (6) can be converted to Reagents A by hydrolysis of the ester using acidic or basic conditions, preferably basic conditions, using an preferably an alkali metal hydroxide such as, for example, NaOH or KOH. After this hydrolysis, treatment with acid to furnish Reagent A. Similar such transformations for the preparation of reagents A have been previously reported (WO2007/26024 A2; US2014/39203 A1).

Scheme 3 Another process for the preparation of reagents A, wherein R¹ and R² have the meaning as given for general formula (I). Compounds of general formula (7) can be converted to Reagents A using basic conditions, such as, for example, NaH, alkali metal alkoxides, to furnish Reagent A. Similar such transformations for the preparation of reagents A have been previously reported (WO2011/62964 A1; 1991 U5505653 A1; Tamura et al., J. Med. Chem., 1977, 20, 709; Huynh et al., Bioorg. Med. Chem., 2012, 20, 6831).

Scheme 4 Another process for the preparation of reagents A, wherein R¹ represents a hydrogen atom and R² represents hydroxyl or R⁷R⁸N— have the meaning as given for general formula (I). Compounds of general formula (8) can be converted to compounds of general formula (9) by using protection methods known to those skilled in the art, such as, for example silyl protecting groups, such as, for example, tert-butyldiphenylsilyl (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). Compounds of general formula (9) can be converted to Reagent A using oxidation methods, such as for example, CrO₃ under acidic conditions. Similar such transformations for the preparation of reagents A have been previously reported (Seitz et al., Synthesis, 2014, 46, 381).

Scheme 5 Another process for the preparation of reagents A, wherein R¹ represents a hydrogen atom and R² represents hydroxyl or R⁷R⁸N— have the meaning as given for general formula (I). Compounds of general formula (10) can be converted to compounds of general formula (11) by using reduction methods, known to those skilled in the art, such as, for example rhodium on alumina, under basic conditions (see the teachings of Smissmann et al., J. Pharm. Sci., 1966, 55, 1101). Compounds of general formula (11) can be converted to compounds of general formula Reagent A by using protection methods, such as, for example, silyl protecting groups, e.g. tert-butyldiphenylsilyl (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999).

Scheme 6 Another process for the preparation of reagents A, wherein R¹ represents a hydrogen atom and R² represents hydroxyl or R⁷R⁸N— have the meaning as given for general formula (I). Compounds of formula (12, Pollak, Monatshefte fuer Chemie, 1893, 14, 403; Hlasiwetz, Justus Liebigs Annalen der Chemie, 1861, 119, 201; Andrus et al., Tetrahedron Lett., 2003, 44, 4819) can be converted to compounds of general formula (13) by using by using protection methods, such as, for example, carbamate protecting groups, e.g. tert-butoxy carbonyl (Boc) (see for further examples T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999 or see the teachings of Hennings et al., Tetrahedron Lett, 1997, 38, 6379 or U.S. Pat. No. 4,872,902 A1). Compounds of general formula (13) can be converted to compounds of general formula Reagent A by using reduction methods, preferably under basic conditions.

Scheme 7 Process for the preparation of reagents C of general formula (14), wherein R⁵ and m have the meaning as given for general formula (I). In addition, interconversion of any of the substituents can be achieved before and/or after the exemplified transformations. These modifications can be such as the introduction of protecting groups, cleavage of protecting groups, reduction or oxidation of functional groups, halogenation, metallation, substitution or other reactions known to the person skilled in the art. These transformations include those which introduce a functionality which allows for further interconversion of substituents. Appropriate protecting groups and their introduction and cleavage are well-known to the person skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). Compounds of general formula 14, whereby LG is a leaving group, such as, for example, F, Cl, Br, I or aryl sulfonate such as for example p-toluene sulfonate, or alkyl sulfonate such as for example methane sulfonate or trifluoromethane sulfonate, are commercially available or can be synthesized by those skilled in the art.

Compounds of general formula (14) can be converted to compounds of general formula (15) by treatment with a suitable nucleophile, such as for example, amines, alcohols, metal alkoxides, azides, thiols or metal thiolates, under either basic, neutral, acidic, catalytic conditions, preferably basic conditions, in a suitable solvent or using the nucleophile as solvent, such as, for example, DMF, tetrahydrofuran (THF), in a temperature range from −78° C. to the boiling point o f the respective solvent, preferably the reaction is carried out −10° C. to the boiling point of the respective solvent, to furnish general formula (15). Such substitution reactions have been previously reported (Clark et al., J. Med. Chem., 2008, 51, 6631-6634; Guo et al., Tetrahedron Letts., 2013, 54, 3233-3237; Watterson et al., J. Med. Chem., 2007, 50, 3730-3742; Bellale et al., J. Med. Chem., 2014,57, 6572-6582; Klimesova et al., Eur. J. Med. Chem., 1996, 31, 389-395; Leroy et al., Synth. Commun., 1997, 27, 2905-2916; LaMattina et al., J. Org. Chem., 1981, 46, 4179-4182; Beugelmans et al., Tetrahedron, 1983, 39, 4153-4162).

Compounds of general formula (15) can be converted to compounds of general formula Reagent C by many reducing methods known to those skilled in the art, using numerous different reagents and reaction conditions; such methods and reagents can be carried out with metal hydrides, such as, for example, lithium aluminium hydride in THF (Bullock et al., J. Am. Chem. Soc., 1956,78, 490, Wang et al., J. Org. Chem., 2006,71, 4021-3160), or using zinc in acetic acid (Rabe, Chem. Ber., 1913, 46, 1024), or using diborane (De Munno et al., Heterocycles, 1996, 43, 1893-1900), or using catalytic hydrogenation methods, for example, hydrogen and palladium on carbon under acidic conditions (Stokker et al., J. Med. Chem., 1981, 24, 115-117; Bertini et al., J. Med. Chem., 2005, 48, 664-670), hydrogen and nickel under basic conditions (Walpole et al., J. Med. Chem., 1993, 36, 2362-2372, Kuramochi et al., Bioorg. Med. Chem., 2005, 13, 4022-4036.)

Scheme 8 Route for the preparation of compounds of general formula (I), wherein R¹, R², R³, A and E have the meaning as given for general formula (I), supra. In addition, interconversion of any of the substituents, R¹, R², R³, A and E can be achieved before and/or after the exemplified transformations. These modifications can be such as the introduction of protecting groups, cleavage of protecting groups, reduction or oxidation of functional groups, halogenation, metallation, substitution or other reactions known to the person skilled in the art. These transformations include those which introduce a functionality which allows for further interconversion of substituents. Appropriate protecting groups and their introduction and cleavage are well-known to the person skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). Specific examples are described in the subsequent paragraphs.

Reagent A, reagent B, and reagent C are either commercllly available or can be prepared according to procedures available from the public domain, as understandable to the person skilled in the art. Specific examples are described in the subsequent paragraphs.

A suitably substituted 1,3-dicarbonyl cyclohexane of general formula (reagent A) can be reacted with a suitably substituted isothiocyanate (reagent B), such as, for example, 3,5-dioxocyclohexanecarboxylic acid or 5-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclohexane-1,3-dione or tert-butyl (3-hydroxy-5-oxocyclohex-3-en-1-yl)carbamate, in a suitable solvent system, such as, for example, acetonitrile, in the presence of a suitable base, such as, for example, triethylamine or DBU, at temperatures ranging from −78° C. to +100° C., preferably the reaction is carried out at 0° C. or +100° C., to furnish general formula (1). Similar reactions have been performed in the literature (Muthusamy, S. et al. J. Heterocyclic Chem., 1991, 28, 759-763; Jagodzinski, S. and Wesolowska; H., Polish Journal of Chemistry, 2001, 75, 387-400; Bolvig, S. et al., Journal of Molecular Structure, 1996, 378, 45-59).

Intermediates of general formula (16) can be converted to intermediates of general formula (17) by reaction with a suitable amine, such as, for example 4-(aminomethyl)pyridine, in a suitable solvent system, such as, for example, ethanol and ethyl acetate, at a temperature between room temperature and the boiling point of the respective solvents, preferably the reaction is carried out at the boiling point of the respective solvents, whereby the water formed in the reaction is removed from the reaction by methods known to those skilled in the art, such as, for example, azeotropic removal of water (Dean-Stark conditions) or with molecular sieves, to furnish general formula (17).

Intermediates of general formula (17) are reacted with a base and/or oxidizing reagent, preferably an oxidizing agent, such as, for example hydrogen peroxide, in a suitable solvent system, such as, for example, methanol, in a temperature range from room temperature to the boiling point of the respective solvent, preferably the reaction is carried out at the boiling point of the respective solvent, to furnish compounds of general formula (I).

Scheme 9 Route for the preparation of compounds of general formula (I), wherein R¹, R², R³, A and E have the meaning as given for general formula (I), supra. In addition, interconversion of any of the substituents, R¹, R², R³, A and E can be achieved before and/or after the exemplified transformations. These modifications can be such as the introduction of protecting groups, cleavage of protecting groups, reduction or oxidation of functional groups, halogenation, metallation, substitution or other reactions known to the person skilled in the art. These transformations include those which introduce a functionality which allows for further interconversion of substituents. Appropriate protecting groups and their introduction and cleavage are well-known to the person skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). Specific examples are described in the subsequent paragraphs.

Reagent A, reagent B, and reagent C are either commercially available or can be prepared according to procedures available from the public domain, as understandable to the person skilled in the art. Specific examples are described in the subsequent paragraphs.

A suitably substituted 1,3-dicarbonyl cyclohexane of general formula (reagent A) could be converted to intermediates of general formula (18) by reaction with a suitable amine, such as, for example 4-(aminomethyl)pyridine, in a suitable solvent system, such as, for example, ethanol and ethyl acetate, at a temperature between room temperature and the boiling point of the respective solvents, preferably the reaction is carried out at the boiling point of the respective solvent, whereby the water formed in the reaction is removed from the reaction by methods known to those skilled in the art, such as, for example, azeotropic removal of water (Dean-Stark conditions) or with molecular sieves, to furnish general formula (18). Similar reactions have been performed in the literature (Fowler, F. et al., Angew. Chem. Int. Ed., 2000, 39, 2132-2135).

Intermediates of general formula (18) can be reacted with a suitably substituted isothiocyanate (B), such as, for example, 3,5-dioxocyclohexanecarboxylic acid or 5-({[tert-butyl(diphenyl)silyl]oxy}methyl)cyclohexane-1,3-dione or tert-butyl (3-hydroxy-5-oxocyclohex-3-en-1-yl)carbamate, in a suitable solvent system, such as, for example, acetonitrile, in the presence of a suitable base, such as, for example, triethylamine or DBU, at temperatures ranging from −78° C. to +100° C., preferably the reaction is carried out at 0° C. or +100′C, to furnish general formula (17).

Intermediates of general formula (17) are reacted with a base and/or oxidizing reagent, preferably an oxidizing agent, such as, for example hydrogen peroxide, in a suitable solvent system, such as, for example, methanol, in a temperature range from room temperature to the boiling point of the respective solvent, preferably the reaction is carried out at the boiling point of the respective solvent, to furnish intermediates of general formula (I).

Scheme 10 Route for the preparation of compounds of general formula (I), wherein R¹, R², R³, A and E have the meaning as given for general formula (I), supra. In addition, interconversion of any of the substituents, R¹, R², R³, A and E can be achieved before and/or after the exemplified transformations. These modifications can be such as the introduction of protecting groups, cleavage of protecting groups, reduction or oxidation of functional groups, halogenation, metallation, substitution or other reactions known to the person skilled in the art. These transformations include those which introduce a functionality which allows for further interconversion of substituents. Appropriate protecting groups and their introduction and cleavage are well-known to the person skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). Specific examples are described in the subsequent paragraphs.

Compounds of the formula (I) can also be prepared using the synthetic methods described in context of Scheme 3. Compounds reagent D and reagent E, are either commercllly available or can be prepared according to procedures available from the public domain, as understandable to the person skilled in the art.

A suitably substituted 1,3-dicarbonyl cyclohexane of general formula (reagent A) could be reacted with suitably substituted compounds of general formula (reagent D) where X¹ is a suitable leaving group, such as, for example, bromide, chloride, preferably bromide, in the presence of an ammonium salt, such as, for example, ammonium acetate, in a suitable solvent, such as, for example, ethanol, in a temperature range from 0° C. to the boiling point of the respective solvent, preferably the reaction is carried out at room temperature, to furnish general formula (19). Similar examples for the formation of a pyrrole ring vl this manner have been previously published using lactams (Anderson, D. R. et al., J. Med. Chem., 2007, 50, 2647-2654; Amici, R. et al., J. Med. Chem., 2008, 51, 487-501; Bargiotti, A. et al., J. Med. Chem., 2009, 52, 293-307).

Intermediates of general formula (19) could be reacted with a suitable halogenating reagent, such as, for example, copper(I) bromide and N-bromosuccinimide, preferably N-bromosuccinimide, in a suitable solvent system, such as, for example, acetonitrile, in a temperature range from 0° C. to the boiling point of the respective solvent, preferably the reaction is carried out at room temperature, to furnish general formula (20). Similar examples for the bromination of pyrroles have been previously published using lactams (Aiello, E. et al., J. Heterocyclic Chem., 1982, 19, 977-979; Duranti, A. et al., Bioorg. Med. Chem., 2003, 11, 3965-3973).

Intermediates of general formula (20) could be reacted with a suitable primary amines, such as, for example, primary aromatic amines and primary amines, preferably primary aromatic amines, such as, for example aniline or 3-aminothiophene, in the presence of a base, such as, for example, lithium bis(trimethylsilyl)amide (LHMDS), in the presence of a catalyst, such as, for example a suitable ligand, preferably 2-(di-tert-butylphosphino)-2′, 4′, 6′-triisopropyl-3,6-dimethoxy-1,1′-biphenyl (tBuBrettPhos) and in the presence of a pre-catalyst, such as, for example a palladium pre-catalyst, preferably chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′, 4′, 6′-triisopropyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) (BrettPhos-PreCat MTBE ether adduct) in a suitable solvent system, such as, for example, tetrahydrofuran (THF), in a temperature range from 0° C. to the 200° C., preferably the reaction is carrie d out at 80° C., to furnish compounds of general formula (I).

Scheme 11 Process for the preparation of compounds of general formula (I). In addition, interconversion of any of the substituents can be achieved before and/or after the exemplified transformations. These modifications can be such as the introduction of protecting groups, cleavage of protecting groups, reduction or oxidation of functional groups, halogenation, metallation, substitution or other reactions known to the person skilled in the art. These transformations include those which introduce a functionality which allows for further interconversion of substituents. Appropriate protecting groups and their introduction and cleavage are well-known to the person skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999).

Compounds of general formula reagent F are commercially available or can be synthesized by those skilled in the art. Compounds of general formula reagent G are commercially available or can be synthesized by those skilled in the art. Compounds of general formula reagent E are commercially available and have been referred to in the previous Schemes. Compounds of general formula reagent F are converted to compounds of general formula (21) by treatment with a suitable brominating agent, such as for example phenyltrimethyammonium tribromide, in a suitable solvent, such as, for example, tetrahydrofuran (THF), in a temperature range from 0° C. to the boiling point of the respective solvent, preferably the reaction is carried out at room temperature, to furnish general formula (21). Such brominations of 1,5,6,7-tetrahydro-4H-indol-4-ones have been previously reported (Davies, H. M. L. and Manning, J. R., J. Am. Chem. Soc., 2006, 128, 1060-1061; Remers, W. A. and Weiss, M. J., J. Org. Chem., 1971, 36, 1241-1247).

Compounds of general formula (21) are then reacted to introduce a suitable protecting group, such as, for example, t-butoxy carbonyl (Boc), onto the pyrrole nitrogen. Reagents for introducing these protecting groups are well-known to those skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). The compounds of general formula (22) can be reacted with a compound of general formula (G) as mentioned above, such as, for example, aromatic boronic acids, heteroaromatic boronic acids, aromatic boronic esters, heteroaromatic boronic esters, preferably primary heteroaromatic boronic acids and heteroaromatic boronic esters, such as, pyridin-4-ylboronic acid and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, in the presence of a base, such as, for example, caesium carbonate, in the presence of a catalyst, such as, for example a palladium catalyst, preferably bis-(triphenylphosphine)palladium(II) dichloride in a suitable solvent system, such as, for example, dimethoxyethane and water, in a temperature range from room temperature to the boiling point of the respective solvent, preferably the reaction is carried out at 80-100° C., to furnish compounds of general formula (23).

Alternatively compounds of general formula (21) can be reacted with a compound of general formula (reagent G) as mentioned above, such as, for example, aromatic boronic acids, heteroaromatic boronic acids, aromatic boronic esters, heteroaromatic boronic esters, preferably primary heteroaromatic boronic acids and heteroaromatic boronic esters, such as, pyridin-4-ylboronic acid and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, in the presence of a base, such as, for example, caesium carbonate, in the presence of a catalyst, such as, for example a palladium catalyst, preferably bis-(triphenylphosphine)palladium(II) dichloride in a suitable solvent system, such as, for example, dimethoxyethane and water, in a temperature range from room temperature to the boiling point of the respective solvent, preferably the reaction is carried out at 80-100° C., to furnish compounds of general formula (19).

Intermediates of general formula (23) can be reacted with a suitable reagent for removing the said protecting group, such methods and their suitable reagents for removing these protecting groups are well-known to those skilled in the art (see for example T. W. Greene and P. G. M. Wuts in Protective Groups in Organic Synthesis, 3rd edition, Wiley 1999). For example, with intermediates of general formula (23) where PG is t-butoxy carbonyl (Boc), can be reacted with an acid, such as for example, hydrochloric acid or trifluoroacetic acid (TFA), in a suitable solvent system, such as, for example, dichloromethane or using the acid as solvent, in a temperature range from 0° C. to the boiling point of the respective solvent, preferably the reaction is carried out at room temperature to furnish compounds of general formula (19).

Intermediates of general formula (19) can be reacted with a suitable halogenating reagent, such as, for example, copper(I) bromide and N-bromosuccinimide, preferably N-bromosuccinimide, in a suitable solvent system, such as, for example, acetonitrile, in a temperature range from 0° C. to the boiling point of the respective solvent, preferably the reaction is carried out at room temperature, to furnish general formula (20). Similar examples for the bromination of pyrroles have been previously published using lactams (Aiello, E. et al., J. Heterocyclic Chem., 1982, 19, 977-979; Duranti, A. et al., Bioorg. Med. Chem., 2003, 11, 3965-3973).

Intermediates of general formula (20) can be reacted with a suitable primary amines, such as, for example, primary aromatic amines and primary amines, preferably primary aromatic amines, such as, for example aniline or 3-aminothiophene, in the presence of a base, such as, for example, lithium bis(trimethylsilyl)amide (LHMDS), in the presence of a catalyst, such as, for example a palladium catalyst, preferably 2-(di-tert-butylphosphino)-2′, 4′, 6′-triisopropyl-3,6-dimethoxy-1,1′-biphenyl (tBuBrettPhos) in a suitable solvent system, such as, for example, tetrahydrofuran (THF), in a temperature range from 0° C. to the 200° C., preferably the reaction is carried out at 80° C., to furnish compounds of general formula (I).

Scheme 12: Route for the preparation of compounds of general formula (Ib), wherein R¹, R², R³, R⁵, A, Q and m have the meaning as given for general formula (I), supra and R¹⁵ represents R⁶—C(O)—, or R⁷R⁸N—C(O)—.

Intermediates of general formula (I-a) are reacted with an acylating reagent, an acylating agent which can be generated in situ, to furnish compounds of general formula (I-b). These types of reactions are well-known (selected literature examples are: S. Miwatashi, et al., J. Med. Chem., 2005, 48, 5966-5979; J. Zhao, et al., Bioorg. Med. Chem. Lett., 2014, 24,. 2802-2806; M. P. Hay, et al., J. Med. Chem., 2010, 53, 787-797; J. M. Keith, et al., Med. Chem. Lett, 2012, 3, 823-827; J. Liang, et al., Eur. J. Med. Chem., 2013, 67, 175-187).

Not-limiting examples of these types of reagents are:

-   -   i) carboxylic acid with dehydrating reagents typically used in         amide bond formation, such as, for example (HBTU, HATU, PyBOP,         BOP, T3P, EDC, DIC, DCC)     -   ii) acid fluorides, acid chlorides, acid bromides, preferably in         the presence of a base     -   iii) acid anhydrides, preferably in the presence of a base     -   iv) chloroformates, preferably in the presence of a base     -   v) isocyanates, preferably in the presence of a base     -   vi) isothiocyanates, preferably in the presence of a base

Intermediates of general formula (I-a) are reacted with an carbonyl containing compounds, such as for example, alcohols, aldehydes and ketones, preferably aldehydes, in the presence of a reducing agent, to furnish compounds of general formula (I-b). These types of reactions, also known as reductive aminations, are well-known (selected literature examples are: Martinez-Asencio et al., Tetrahedron Letts., 2010, 51, 325-327; Martinez-Asencio et al., Org. Biomol. Chem., 2009, 7, 2176-2181; Ikeda et al., Eur. J. Med. Chem., 2011, 46, 636-646.

Not-limiting examples of these types of reagents are:

-   -   i) alcohols with 2-aminopyridines in the presence of base, for         example KO^(t)Bu, and copper acetate or nano-Fe₃O₄         (Martinez-Asencio et al., Tetrahedron Letts., 2010, 51, 325-327;         Martinez-Asencio et al., Org. Biomol. Chem., 2009, 7,         2176-2181).     -   ii) Aldehydes with reducing agents, such as for example, sodium         borohydride or sodium cyanoborohydride or sodium         tris(acetoxy)borohydride, preferably in the presence of an acid,         such as acetic acid; Ikeda et al., Eur. J. Med. Chem., 2011, 46,         636-646; Eur. J. Med. Chem., 2000, 35, 815-826; Betzel et al.,         Bioconjugate Chem., 2013, 24, 205-214.     -   iii) Aldehydes under catalytic hydrogenation conditions with a         catalyst, suc as for example Pd/NiO under an H2 atmosphere (Yang         et al., Synth. Commun., 2014, 44, 1314-1322).

Scheme 13 Process for the preparation of compounds of general formula (I-d), wherein R¹, R², R³, A, E have the meaning as given for general formula (I) and Q represents (=NOH). Compounds of general formula (I-c) wherein Q represents O can be converted to compounds of general formula (I-d) wherein Q represents (═NOH) by treatment with a suitable reagent containing one or more NH2 group, such as for example, amines, oxyamines, hydroxylamines, hydrazones or hydrazines, preferably hydroxylamine, in a suitable solvent, such as, for example, ethanol, methanol, water, DMF, tetrahydrofuran (THF), preferably, ethanol, in a temperature range from −78° C. to the boiling point of the respective solvent, preferably the reaction is carried out RT to the boiling point of the respective solvent, to furnish general formula (I). Such transformations have been previously reported (Kesten et al., J. Med. Chem., 1992, 35, 3429-3447; Bisejieks et al., Heteocyclic Comunn., 2005, 11, 9-12; Maillard et al., Eur. J. Med. Chem., 1984, 19, 451-456; Hassan, Molecules, 2013, 18, 2683-2711).

Scheme 14 Route for the preparation of compounds of general formula (I-g), wherein R¹, R³, R⁷, R⁸, A, E and Q have the meaning as given for general formula (I), supra. Intermediates of general formula (I-e) are be hydrolysed under acidic or basic conditions, preferably basic condidions using an alkali metal hydroxide, such as, for example NaOH to furnish intermediates of general formula (I-f). Intermediates of general formula (I-f) are reacted with a nucleophile, preferably amines using dehydrating reagents, such as, for example, HBTU, HATU, PyBOP, BOP, T3P, EDC, DIC, DCC, to furnish compounds of general formula (I-g), these types of reactions are well-known to those skilled in the art (selected literature examples are: Su, et al., J. Nat. Prod., 2001, 64, 466; Sakagami, et al., Chem. Pharm. Bull., 2007, 55, 37; Demont, et al., Synlett., 2004, 684; Jackson, et al., Bioorg. Med. Chem. Lett., 2002, 12, 1093).

Scheme 15 Route for the preparation of compounds of general formula (I-m), wherein R¹, R³, R⁵, R⁷, R⁸, A, E, m and Q have the meaning as given for general formula (I), supra and R¹⁵ represents R⁶—C(O)—, or R⁷R⁸N—C(O)—. Intermediates of general formula (I-h) are reacted with an acylating reagent, a sulfonylating reagent or an acylated agent which can be generated in situ, to furnish Intermediates of general formula (I-j), these types of reactions are well-known to those skilled in the art (selected literature examples are: S. Miwatashi, et al., J. Med. Chem., 2005, 48, 5966-5979; J. Zhao, et al., Bioorg. Med. Chem. Lett., 2014, 24,. 2802-2806; M. P. Hay, et al., J. Med. Chem., 2010, 53, 787-797; J. M. Keith, et al., Med. Chem. Lett, 2012, 3, 823-827; J. Liang, et al., Eur. J. Med. Chem., 2013, 67, 175-187; D. Lesuisse, et al., Bioorg. Med. Chem. Lett., 2011, 21, 2224-2228).

is Not-limiting examples of these types of reagents can be:

-   -   i) carboxylic acid with dehydrating reagents typically used in         amide bond formation, such as, for example (HBTU, HATU, PyBOP,         BOP, T3P, EDC, DIG, DCC)     -   ii) acid fluorides, acid chlorides, acid bromides, preferably in         the presence of a base     -   iii) acid anhydrides, preferably in the presence of a base     -   iv) chloroformates, preferably in the presence of a base     -   v) isocyanates, preferably in the presence of a base

Intermediates of general formula (I-j) are be hydrolysed under acidic or basic conditions, preferably basic condidions using an alkali metal hydroxide, such as, for example NaOH to furnish intermediates of general formula (I-k). Intermediates of general formula (I-k) are reacted with an nucleophile, preferably amines using dehydrating reagents, such as, for example, HBTU, HATU, PyBOP, BOP, T3P, EDC, DIC, DCC, to furnish Intermediates of general formula (I-m), these types of reactions are well-known to those skilled in the art (selected literature examples are: Su, et al., J. Nat. Prod., 2001, 64, 466; Sakagami, et al., Chem. Pharm. Bull., 2007, 55, 37; Demont, et al., Synlett., 2004, 684; Jackson, et al., Bioorg. Med. Chem. Lett., 2002, 12, 1093).

Scheme 16 Route for the preparation of compounds of general formula (I-q), wherein R¹, R³, R¹¹, A, E and Q have the meaning as given for general formula (I), supra and LG is a leaving group, such as, for example, F, Cl, Br, I or aryl sulfonate such as for example p-toluene sulfonate, or alkyl sulfonate such as for example methane sulfonate or trifluoromethane sulfonate. Intermediates of general formula (I-p) can be converted to intermediates of general formula (I-q) using methods well-known to those skilled in the art. (selected literature examples are: Garro, et al., Eur. J. Med. Chem., 2014, 71, 237; Heathcock, et al., J. Am. Chem. Soc., 1982, 104, 1907; Matsumoto et al., Tetrahedron Lett., 2000, 41, 8393; Lightner, et al., J. Am. Chem. Soc., 1985, 107, 7499; Ryall, et al., Synth. Commun., 1990, 20, 431; Tsuda et al., Chem. Pharm. Bull., 1990, 38, 2136).

Scheme 17 Route for the preparation of compounds of general formula (I-s), wherein R¹, R³, A, E and Q have the meaning as given for general formula (I), supra and R¹⁶ represents R⁶—C(O)—, R⁶—O—C(O)— or R⁷R⁸N—C(O)—. Intermediates of general formula (I-r) are reacted with an acylating reagent, an acylating agent which can be generated in situ, to furnish compounds of general formula (I-s). These types of reactions are well-known (selected literature examples are: S. Miwatashi, et al., J. Med. Chem., 2005, 48, 5966 5979; J. Zhao, et al., Bioorg. Med. Chem. Lett., 2014, 24,. 2802-2806; M. P. Hay, et al., J. Med. Chem., 2010, 53, 787-797; J. M. Keith, et al., Med. Chem. Lett, 2012, 3, 823-827; J. Liang, et al., Eur. J. Med. Chem., 2013, 67, 175-187).

Not-limiting examples of these types of reagents are:

-   -   i) carboxylic acid with dehydrating reagents typically used in         amide bond formation, such as, for example (HBTU, HATU, PyBOP,         BOP, T3P, EDC, DIC, DCC)     -   ii) acid fluorides, acid chlorides, acid bromides, preferably in         the presence of a base     -   iii) acid anhydrides, preferably in the presence of a base     -   iv) chloroformates, preferably in the presence of a base     -   v) isocyanates, preferably in the presence of a base     -   vi) isothiocyanates, preferably in the presence of a base

Intermediates of general formula (I-r) are reacted with an carbonyl containing compounds, such as for example, alcohols, aldehydes and ketones, preferably aldehydes, in the presence of a reducing agent, to furnish compounds of general formula (I-s). These types of reactions, also known as reductive aminations, are well-known (selected literature examples are: Martinez-Asencio et al., Tetrahedron Letts., 2010, 51, 325-327; Martinez-Asencio et al., Org. Biomol. Chem., 2009, 7, 2176-2181; Ikeda et al., Eur. J. Med. Chem., 2011, 46, 636-646.

Not-limiting examples of these types of reagents are:

-   -   iv) alcohols with 2-aminopyridines in the presence of base, for         example KO^(t)Bu, and copper acetate or nano-Fe₃O₄         (Martinez-Asencio et al., Tetrahedron Letts., 2010, 51, 325-327;         Martinez-Asencio et al., Org. Biomol. Chem., 2009, 7,         2176-2181).     -   v) Aldehydes with reducing agents, such as for example, sodium         borohydride or sodium cyanoborohydride or sodium         tris(acetoxy)borohydride, preferably in the presence of an acid,         such as acetic acid; Ikeda et al., Eur. J. Med. Chem., 2011, 46,         636-646; Eur. J. Med. Chem., 2000, 35, 815-826; Betzel et al.,         Bioconjugate Chem., 2013, 24, 205-214.     -   vi) Aldehydes under catalytic hydrogenation conditions with a         catalyst, suc as for example Pd/NiO under an H2 atmosphere (Yang         et al., Synth. Commun., 2014, 44, 1314-1322).

Scheme 18 Route for the preparation of compounds of general formula (I), wherein R¹, R², R³, A, E and Q have the meaning as given for general formula (I).

Compounds of general formula (I-t) can be converted to compounds of general formula (I) by treatment with a suitable base, such as, for example, alkali metal carbonate, alkali metal hydrogen carbonate, alkali metal hydroxide, sodium hydride, alkali metal alkoxide, LHMDS, optionally in the presence of a phase transfer catalyst, or a crown ether, with an alkylating reagent which contains a suitable leaving group, such as, for example, F, Cl, Br, I or aryl sulfonate such as for example para-toluene sulfonate, or alkyl sulfonate such as for example methane sulfonate or trifluoromethane sulfonate, are commercially available or can be synthesized by those skilled in the art, in a suitable solvent, such as, for example, ethanol, methanol, water, DMF, tetrahydrofuran (THF), preferably, DMF, in a temperature range from −78° C. to the boiling point o f the respective solvent, preferably the reaction is carried out RT to the boiling point of the respective solvent, to furnish general formula (I).

Such transformations have been previously reported (Zhang et al., Bioorg. Med. Chem. Lett., 2006, 16, 3233-3237; WO2008/132434 A2, Kang et al., Bioorg. Med. Chem., 2010, 18, 6156-6169; Vanotti et al., J. Med. Chem., 2008, 51, 487-501).

Scheme 19 Route for the preparation of compounds of general formula (I-x), wherein R¹, R³, R⁶, A, E and Q have the meaning as given for general formula (I), supra and t is 1 or 2. Intermediates of general formula (I-v) can be reacted with an oxidizing agent, such as, for example, meta-chloroperbenzoic acid, hydrogen peroxide, dimethyl dioxirane in a suitable solvent system, such as, for example, dichloromethane, chloroform, acetone in a temperature range from −78° C. to the boiling point of the respective solvent, to furnish compounds of general formula (I-x), these types of reactions are well-known to those skilled in the art (selected literature examples are: C. J. Moody et al., Terahedron., 1990, 46, 6525-6544; K. Matsumoto, et al., Heterocycles, 2008, 76, 191-196).

It is known to the person skilled in the art that, if there are a number of reactive centers on a starting or intermediate compound, it may be necessary to block one or more reactive centers temporarily by protective groups in order to allow a reaction to proceed specifically at the desired reaction center. A detailed description for the use of a large number of proven protective groups is found, for example, in T. W. Greene, Protective Groups in Organic Synthesis, John Wiley & Sons, 1999, 3rd Ed., or in P. Kocienski, Protecting Groups, Thieme Medical Publishers, 2000.

The compounds according to the invention are isolated and purified in a manner known per se, e.g. by distilling off the solvent in vacua and recrystallizing the residue obtained from a suitable solvent or subjecting it to one of the customary purification methods, such as chromatography on a suitable support material. Furthermore, reverse phase preparative HPLC of compounds of the present invention which possess a sufficiently basic or acidic functionality, may result in the formation of a salt, such as, in the case of a compound of the present invention which is sufficiently basic, a trifluoroacetate or formate salt for example, or, in the case of a compound of the present invention which is sufficiently acidic, an ammonium salt for example. Salts of this type can either be transformed into its free base or free acid form, respectively, by various methods known to the person skilled in the art, or be used as salts in subsequent biological assays. Additionally, the drying process during the isolation of compounds of the present invention may not fully remove traces of cosolvents, especllly such as formic acid or trifluoroacetic acid, to give solvates or inclusion complexes. The person skilled in the art will recognise which solvates or inclusion complexes are acceptable to be used in subsequent biological assays. It is to be understood that the specific form (e.g. salt, free base, solvate, inclusion complex) of a compound of the present invention as isolated as described herein is not necessarily the only form in which said compound can be applied to a biological assay in order to quantify the specific biological activity.

Salts of the compounds according to the invention can be obtained by dissolving the free compound in a suitable solvent (for example a ketone such as acetone, methylethylketone or methylisobutylketone, an ether such as diethyl ether, tetrahydrofuran or dioxane, a chlorinated hydrocarbon such as methylene chloride or chloroform, or a low molecular weight aliphatic alcohol such as methanol, ethanol or isopropanol) which contains the desired acid or base, or to which the desired acid or base is then added. The acid or base can be employed in salt preparation, depending on whether a mono- or polybasic acid or base is concerned and depending on which salt is desired, in an equimolar quantitative ratio or one differing therefrom. The salts are obtained by filtering, reprecipitating, precipitating with a non-solvent for the salt or by evaporating the solvent. Salts obtained can be converted into the free compounds which, in turn, can be converted into salts. In this manner, pharmaceutically unacceptable salts, which can be obtained, for example, as process products in the manufacturing on an industrial scale, can be converted into pharmaceutically acceptable salts by processes known to the person skilled in the art. Especially preferred are hydrochlorides and the process used in the example section.

Pure diastereomers and pure enantiomers of the compounds and salts according to the invention can be obtained e.g. by asymmetric synthesis, by using chiral starting compounds in synthesis and by splitting up enantiomeric and diasteriomeric mixtures obtained in synthesis.

Enantiomeric and diastereomeric mixtures can be split up into the pure enantiomers and pure diastereomers by methods known to a person skilled in the art. Preferably, diastereomeric mixtures are separated by crystallization, in particular fractional crystallization, or chromatography. Enantiomeric mixtures can be separated e.g. by forming dlstereomers with a chiral auxillry agent, resolving the dlstereomers obtained and removing the chiral auxilliary agent. As chiral auxilliary agents, for example, chiral acids can be used to separate enantiomeric bases such as e.g. mandelic acid and chiral bases can be used to separate enantiomeric acids vl formation of dlstereomeric salts. Furthermore, diastereomeric derivatives such as diastereomeric esters can be formed from enantiomeric mixtures of alcohols or enantiomeric mixtures of acids, respectively, using chiral acids or chiral alcohols, respectively, as chiral auxilliary agents. Additionally, diastereomeric complexes or diastereomeric clathrates may be used for separating enantiomeric mixtures. Alternatively, enantiomeric mixtures can be split up using chiral separating columns in chromatography. Another suitable method for the isolation of enantiomers is the enzymatic separation.

One preferred aspect of the invention is the process for the preparation of the compounds of the claims 1 to 5, according to the examples, as well as the intermediates used for their preparation.

Optionally, compounds of formula (I) according to the invention can be converted into their salts, or, optionally, salts of the compounds according to the invention can be converted into the free compounds. Corresponding processes are customary for the skilled person.

Commercial utility

As mentioned supra, the compounds of the present invention have surprisingly been found to effectively inhibit Bub1 finally resulting in cell death e.g. apoptosis and may therefore be used for the treatment or prophylaxis of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses, or diseases which are accompanied with uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses, particularly in which the uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses is mediated by Bubl, such as, for example, benign and malignant neoplasia, more specifically haematological tumours, solid tumours, and/or metastases thereof, e.g. leukaemias and myelodysplastic syndrome, malignant lymphomas, head and neck tumours including brain tumours and brain metastases, tumours of the thorax including non-small cell and small cell lung tumours, gastrointestinal tumours, endocrine tumours, mammary and other gynaecological tumours, urological tumours including renal, bladder and prostate tumours, skin tumours, and sarcomas, and/or metastases thereof,

especially haematological tumours, solid tumours, and/or metastases of breast, bladder, bone, brain, central and peripheral nervous system, cervix, colon, endocrine glands (e.g. thyroid and adrenal cortex), endocrine tumours, endometrium, esophagus, gastrointestinal tumours, germ cells, kidney, liver, lung, larynx and hypopharynx, mesothelioma, ovary, pancreas, prostate, rectum, renal, small intestine, soft tissue, stomach, skin, testis, ureter, vagina and vulva as well as malignant neoplasias including primary tumors in said organs and corresponding secondary tumors in distant organs (“tumor metastases”). Haematological tumors can e.g be exemplified by aggressive and indolnt forms of leukemia and lymphoma, namely non-Hodgkins disease, chronic and acute myeloid leukemia (CML/AML), acute lymphoblastic leukemia (ALL), Hodgkins disease, multiple myeloma and T-cell lymphoma. Also included are myelodysplastic syndrome, plasma cell neoplasia, paraneoplastic syndromes, and cancers of unknown primary site as well as AIDS related malignancies.

A further aspect of the invention is the use of the compounds of formula (I) according to the invention for the treatment of cer-vical -, breast -, non-small cell lung -, prostate -, colon- and melanoma tumors and/or metastases thereof, especially preferred for the treatment thereof as well as a method of treatment of cervical -, breast -, non-small cell lung -, prostate -, colon- and melanoma tumors and/or metastases thereof comprising administering an effective amount of a compound according to the invention.

One aspect of the invention is the use of the compounds of formula (I) according to the invention for the treatment of cervix tumors as well as a method of treatment of cervix tumors comprising administering an effective amount of a compound according to the invention.

In accordance with an aspect of the present invention therefore the invention relates to a compound of formula (I) according to the invention, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer particularly a pharmaceutically acceptable salt thereof, or a mixture of same, as described and defined herein, for use in the treatment or prophylaxis of a disease, especially for use in the treatment of a disease.

Another particular aspect of the present invention is therefore the use of a compound of formula (I) according to the invention, described supra, or a stereoisomer, a tautomer, an lo N-oxide, a hydrate, a solvate, or a salt thereof, particularly a pharmaceutically acceptable salt thereof, or a mixture of same, for the prophylaxis or treatment of hyperproliferative disorders or disorders responsive to induction of cell death i.e apoptosis.

The term “inappropriate” within the context of the present invention, in particular in the context of “inappropriate cellular immune responses, or inappropriate cellular inflammatory responses”, as used herein, is to be understood as preferably meaning a response which is less than, or greater than normal, and which is associated with, responsible for, or results in, the pathology of said diseases.

Preferably, the use is in the treatment or prophylaxis of diseases, especially the treatment, wherein the diseases are haematological tumours, solid tumours and/or metastases thereof.

Another aspect is the use of a compound of formula (I) according to the invention for the treatment of cervical -, breast -, non-small cell lung -, prostate -, colon- and melanoma tumors and/or metastases thereof, especially preferred for the treatment thereof. A preferred aspect is the use of a compound of formula (I) according to the invention for the prophylaxis and/or treatment of cervical tumors especially preferred for the treatment thereof.

Another aspect of the present invention is the use of a compound according to the invention or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, particularly a pharmaceutically acceptable salt thereof, or a mixture of same, as described herein, in the manufacture of a medicament for the treatment or prophylaxis of a disease, wherein such disease is a hyperproliferative disorder or a disorder responsive to induction of cell death e.g.apoptosis. In an embodiment the disease is a haematological tumour, a solid tumour and/or metastases thereof. In another embodiment the disease is cervical -, breast -, non-small cell lung -, prostate -, colon- and melanoma tumor and/or metastases thereof, in a preferred aspect the disease is cervical tumor.

Method of Treating Hyper-Proliferative Disorders

The present invention relates to a method for using the compounds of the present invention and compositions thereof, to treat mammalian hyper-proliferative disorders. Compounds can be utilized to inhibit, block, reduce, decrease, etc., cell proliferation and/or cell division, and/or produce cell death e.g. apoptosis. This method comprises administering to a mammal in need thereof, including a human, an amount of a compound of this invention, or a pharmaceutically acceptable salt, isomer, polymorph, metabolite, hydrate, solvate or ester thereof; etc. which is effective to treat the disorder. Hyperproliferative disorders include but are not limited, e.g., psoriasis, keloids, and other hyperplasias affecting the skin, benign prostate hyperplasia (BPH), solid tumours, such as cancers of the breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, skin, head and neck, thyroid, parathyroid and their distant metastases. Those disorders also include lymphomas, sarcomas, and leukaemias.

Examples of breast cancer include, but are not limited to invasive ductal carcinoma, invasive lobular carcinoma, ductal carcinoma in situ, and lobular carcinoma in situ.

Examples of cancers of the respiratory tract include, but are not limited to small-cell and non-small-cell lung carcinoma, as well as bronchial adenoma and pleuropulmonary blastoma.

Examples of brain cancers include, but are not limited to brain stem and hypophtalmic glioma, cerebellar and cerebral astrocytoma, medulloblastoma, ependymoma, as well as neuroectodermal and pineal tumour.

Tumours of the male reproductive organs include, but are not limited to prostate and testicular cancer. Tumours of the female reproductive organs include, but are not limited to endometrial, cervical, ovarian, vaginal, and vulvar cancer, as well as sarcoma of the uterus.

Tumours of the digestive tract include, but are not limited to anal, colon, colorectal, oesophageal, gallbladder, gastric, pancreatic, rectal, small-intestine, and salivary gland cancers.

Tumours of the urinary tract include, but are not limited to bladder, penile, kidney, renal pelvis, ureter, urethral and human papillary renal cancers.

Eye cancers include, but are not limited to intraocular melanoma and retinoblastoma.

Examples of liver cancers include, but are not limited to hepatocellular carcinoma (liver cell carcinomas with or without fibrolamellar variant), cholangiocarcinoma (intrahepatic bile duct carcinoma), and mixed hepatocellular cholangiocarcinoma.

Skin cancers include, but are not limited to squamous cell carcinoma, Kaposi's sarcoma, malignant melanoma, Merkel cell skin cancer, and non-melanoma skin cancer.

Head-and-neck cancers include, but are not limited to laryngeal, hypopharyngeal, nasopharyngeal, oropharyngeal cancer, lip and oral cavity cancer and squamous cell. Lymphomas include, but are not limited to AIDS-related lymphoma, non-Hodgkin's lymphoma, cutaneous T-cell lymphoma, Burkitt lymphoma, Hodgkin's disease, and lymphoma of the central nervous system.

Sarcomas include, but are not limited to sarcoma of the soft tissue, osteosarcoma, malignant fibrous histiocytoma, lymphosarcoma, and rhabdomyosarcoma.

Leukemias include, but are not limited to acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, and hairy cell leukemia.

These disorders have been well characterized in humans, but also exist with a similar etiology in other mammals, and can be treated by administering pharmaceutical compositions of the present invention.

The term “treating” or “treatment” as stated throughout this document is used conventionally, e.g., the management or care of a subject for the purpose of combating, alleviating, reducing, relieving, improving the condition of, etc., of a disease or disorder, such as a carcinoma.

Methods of Treating Kinase Disorders

The present invention also provides methods for the treatment of disorders associated with aberrant mitogen extracellular kinase activity, including, but not limited to stroke, heart failure, hepatomegaly, cardiomegaly, diabetes, Alzheimer's disease, cystic fibrosis, symptoms of xenograft rejections, septic shock or asthma.

Effective amounts of compounds of the present invention can be used to treat such disorders, including those diseases (e.g., cancer) mentioned in the Background section above. Nonetheless, such cancers and other diseases can be treated with compounds of the present invention, regardless of the mechanism of action and/or the relationship between the kinase and the disorder.

The phrase “aberrant kinase activity” or “aberrant tyrosine kinase activity,” includes any abnormal expression or activity of the gene encoding the kinase or of the polypeptide it encodes. Examples of such aberrant activity, include, but are not limited to, over-expression of the gene or polypeptide; gene amplification; mutations which produce constitutively-active or hyperactive kinase activity; gene mutations, deletions, substitutions, additions, etc.

The present invention also provides for methods of inhibiting a kinase activity, especially of mitogen extracellular kinase, comprising administering an effective amount of a compound of the present invention, including salts, polymorphs, metabolites, hydrates, solvates, prodrugs (e.g.: esters) thereof, and diastereoisomeric forms thereof. Kinase activity can be inhibited in cells (e.g., in vitro), or in the cells of a mammalian subject, especially a human patient in need of treatment.

Methods of Treating Angiogenic Disorders

The present invention also provides methods of treating disorders and diseases associated with excessive and/or abnormal angiogenesis.

Inappropriate and ectopic expression of angiogenesis can be deleterious to an organism. A number of pathological conditions are associated with the growth of extraneous blood vessels. These include, e.g., diabetic retinopathy, ischemic retinal-vein occlusion, and retinopathy of prematurity [Aiello et al. New Engl. J. Med. 1994, 331, 1480; Peer et al. Lab. Invest. 1995, 72, 638], age-related macular degeneration [AMD; see, Lopez et al. Invest. Opththalmol. Vis. Sci. 1996, 37, 855], neovascular glaucoma, psoriasis, retrolental fibroplasias, angiofibroma, inflammation, rheumatoid arthritis (RA), restenosis, in-stent restenosis, vascular graft restenosis, etc. In addition, the increased blood supply associated with cancerous and neoplastic tissue, encourages growth, leading to rapid tumour enlargement and metastasis. Moreover, the growth of new blood and lymph vessels in a tumour provides an escape route for renegade cells, encouraging metastasis and the consequence spread of the cancer. Thus, compounds of the present invention can be utilized to treat and/or prevent any of the aforementioned angiogenesis disorders, e.g., by inhibiting and/or reducing blood vessel formation; by inhibiting, blocking, reducing, decreasing, etc. endothelial cell proliferation or other types involved in angiogenesis, as well as causing cell death e.g. apoptosis of such cell types.

Preferably, the diseases of said method are haematological tumours, solid tumour and/or metastases thereof.

The compounds of the present invention can be used in particular in therapy and prevention i.e. prophylaxis, especially in therapy of tumour growth and metastases, especially in solid tumours of all indications and stages with or without pre-treatment of the tumour growth.

Pharmaceutical Compositions of the Compounds of the Invention

This invention also relates to pharmaceutical compositions containing one or more compounds of the present invention. These compositions can be utilised to achieve the desired pharmacological effect by administration to a patient in need thereof. A patient, for the purpose of this invention, is a mammal, including a human, in need of treatment for the particular condition or disease.

Therefore, the present invention includes pharmaceutical compositions that are comprised of a pharmaceutically acceptable carrier or auxiliary and a pharmaceutically effective amount of a compound, or salt thereof, of the present invention.

Another aspect of the invention is a pharmaceutical composition comprising a pharmaceutically effective amount of a compound of formula (I) according to the invention and a pharmaceutically acceptable auxiliary for the treatment of a disease mentioned supra, especially for the treatment of haematological tumours, solid tumours and/or metastases thereof.

A pharmaceutically acceptable carrier or auxiliary is preferably a carrier that is non-toxic and innocuous to a patient at concentrations consistent with effective activity of the active ingredient so that any side effects ascribable to the carrier do not vitiate the beneficial effects of the active ingredient. Carriers and auxiliaries are all kinds of additives assisting to the composition to be suitable for administration.

A pharmaceutically effective amount of compound is preferably that amount which produces a result or exerts the intended influence on the particular condition being treated.

The compounds of the present invention can be administered with pharmaceutically-acceptable carriers or auxiliaries well known in the art using any effective conventional dosage unit forms, including immediate, slow and timed release preparations, orally, parenterally, topically, nasally, ophthalmically, optically, sublingually, rectally, vaginally, and the like.

For oral administration, the compounds can be formulated into solid or liquid preparations such as capsules, pills, tablets, troches, lozenges, melts, powders, solutions, suspensions, or emulsions, and may be prepared according to methods known to the art for the manufacture of pharmaceutical compositions. The solid unit dosage forms can be a capsule that can be of the ordinary hard- or soft-shelled gelatine type containing auxiliaries, for example, surfactants, lubricants, and inert fillers such as lactose, sucrose, calcium phosphate, and corn starch.

In another embodiment, the compounds of this invention may be tableted with conventional tablet bases such as lactose, sucrose and cornstarch in combination with is binders such as acacia, corn starch or gelatine, disintegrating agents intended to assist the break-up and dissolution of the tablet following administration such as potato starch, alginic acid, corn starch, and guar gum, gum tragacanth, acacia, lubricants intended to improve the flow of tablet granulation and to prevent the adhesion of tablet material to the surfaces of the tablet dies and punches, for example talc, stearic acid, or magnesium, calcium or zinc stearate, dyes, colouring agents, and flavouring agents such as peppermint, oil of wintergreen, or cherry flavouring, intended to enhance the aesthetic qualities of the tablets and make them more acceptable to the patient. Suitable excipients for use in oral liquid dosage forms include dicalcium phosphate and diluents such as water and alcohols, for example, ethanol, benzyl alcohol, and polyethylene alcohols, either with or without the addition of a pharmaceutically acceptable surfactant, suspending agent or emulsifying agent. Various other materials may be present as coatings or to otherwise modify the physical form of the dosage unit. For instance tablets, pills or capsules may be coated with shellac, sugar or both.

Dispersible powders and granules are suitable for the preparation of an aqueous suspension. They provide the active ingredient in admixture with a dispersing or wetting agent, a suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example those sweetening, flavouring and colouring agents described above, may also be present.

The pharmaceutical compositions of this invention may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil such as liquid paraffin or a mixture of vegetable oils. Suitable emulsifying agents may be (1) naturally occurring gums such as gum acacia and gum tragacanth, (2) naturally occurring phosphatides such as soy bean and lecithin, (3) esters or partial esters derived form fatty acids and hexitol anhydrides, for example, sorbitan monooleate, (4) condensation products of said partial esters with ethylene oxide, for example, polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavouring agents.

Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil such as, for example, arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent such as, for example, beeswax, hard paraffin, or cetyl alcohol. The suspensions may also contain one or more preservatives, for example, ethyl or n-propyl p-hydroxybenzoate; one or more colouring agents; one or more flavouring agents; and one or more sweetening agents such as sucrose or saccharin.

Syrups and elixirs may be formulated with sweetening agents such as, for example, glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, and preservative, such as methyl and propyl parabens and flavouring and colouring agents.

The compounds of this invention may also be administered parenterally, that is, subcutaneously, intravenously, intraocularly, intrasynovially, intramuscularly, or interperitoneally, as injectable dosages of the compound in preferably a physiologically acceptable diluent with a pharmaceutical carrier which can be a sterile liquid or mixture of liquids such as water, saline, aqueous dextrose and related sugar solutions, an alcohol such as ethanol, isopropanol, or hexadecyl alcohol, glycols such as propylene glycol or polyethylene glycol, glycerol ketals such as 2,2-dimethyl-1,1-dioxolane-4-methanol, ethers such as poly(ethylene glycol) 400, an oil, a fatty acid, a fatty acid ester or, a fatty acid glyceride, or an acetylated fatty acid glyceride, with or without the addition of a pharmaceutically acceptable surfactant such as a soap or a detergent, suspending agent such as pectin, carbomers, methycellulose, hydroxypropylmethylcellulose, or carboxymethylcellulose, or emulsifying agent and other pharmaceutical adjuvants.

Illustrative of oils which can be used in the parenteral formulations of this invention are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, sesame oil, cottonseed oil, corn oil, olive oil, petrolatum and mineral oil. Suitable fatty acids include oleic acid, stearic acid, isostearic acid and myristic acid. Suitable fatty acid esters are, for example, ethyl oleate and isopropyl myristate. Suitable soaps include fatty acid alkali metal, ammonium, and triethanolamine salts and suitable detergents include cationic detergents, for example dimethyl dialkyl ammonium halides, alkyl pyridinium halides, and alkylamine acetates; anionic detergents, for example, alkyl, aryl, and olefin sulfonates, alkyl, olefin, ether, and monoglyceride sulfates, and sulfosuccinates; non-ionic detergents, for example, fatty amine oxides, fatty acid alkanolamides, and poly(oxyethylene-oxypropylene)s or ethylene oxide or propylene oxide copolymers; and amphoteric detergents, for example, alkyl-beta-aminopropionates, and 2-alkylimidazoline quarternary ammonium salts, as well as mixtures.

The parenteral compositions of this invention will typically contain from about 0.5% to about 25% by weight of the active ingredient in solution. Preservatives and buffers may also be used advantageously. In order to minimise or eliminate irritation at the site of injection, such compositions may contain a non-ionic surfactant having a hydrophile-lipophile balance (HLB) preferably of from about 12 to about 17. The quantity of surfactant in such formulation preferably ranges from about 5% to about 15% by weight. The surfactant can be a single component having the above HLB or can be a mixture of two or more components having the desired HLB.

Illustrative of surfactants used in parenteral formulations are the class of polyethylene sorbitan fatty acid esters, for example, sorbitan monooleate and the high molecular weight adducts of ethylene oxide with a hydrophobic base, formed by the condensation of propylene oxide with propylene glycol.

The pharmaceutical compositions may be in the form of sterile injectable aqueous suspensions. Such suspensions may be formulated according to known methods using suitable dispersing or wetting agents and suspending agents such as, for example, sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethyl-cellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents which may be a naturally occurring phosphatide such as lecithin, a condensation product of an alkylene oxide with a fatty acid, for example, polyoxyethylene stearate, a condensation product of ethylene oxide with a long chain aliphatic alcohol, for example, heptadeca-ethyleneoxycetanol, a condensation product of ethylene oxide with a partial ester derived form a fatty acid and a hexitol such as polyoxyethylene sorbitol monooleate, or a condensation product of an ethylene oxide with a partial ester derived from a fatty acid and a hexitol anhydride, for example polyoxyethylene sorbitan monooleate.

The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally acceptable diluent or solvent. Diluents and solvents that may be employed are, for example, water, Ringer's solution, isotonic sodium chloride solutions and isotonic glucose solutions. In addition, sterile fixed oils are conventionally employed as solvents or suspending media. For this purpose, any bland, fixed oil may be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid can be used in the preparation of injectables.

A composition of the invention may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritation excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are, for example, cocoa butter and polyethylene glycol.

Controlled release formulations for parenteral administration include liposomal, polymeric microsphere and polymeric gel formulations that are known in the art.

It may be desirable or necessary to introduce the pharmaceutical composition to the patient via a mechanical delivery device. The construction and use of mechanical delivery devices for the delivery of pharmaceutical agents is well known in the art. Direct techniques for administration, for example, administering a drug directly to the brain usually involve placement of a drug delivery catheter into the patient's ventricular system to bypass the blood-brain barrier. One such implantable delivery system, used for the transport of agents to specific anatomical regions of the body, is described in U.S. Pat. No. 5,011,472, issued Apr. 30, 1991.

The compositions of the invention can also contain other conventional pharmaceutically acceptable compounding ingredients, generally referred to as carriers or diluents, as necessary or desired. Conventional procedures for preparing such compositions in appropriate dosage forms can be utilized.

Such ingredients and procedures include those described in the following references, each of which is incorporated herein by reference: Powell, M. F. et al., “Compendium of Excipients for Parenteral Formulations” PDA Journal of Pharmaceutical Science & Technology 1998, 52(5), 238-311; Strickley, R. G “Parenteral Formulations of Small Molecule Therapeutics Marketed in the United States (1999)-Part-1” PDA Journal of Pharmaceutical Science & Technology 1999, 53(6), 324-349; and Nema, S. et al., “Excipients and Their Use in Injectable Products” PDA Journal of Pharmaceutical Science & Technology 1997, 51(4), 166-171.

Commonly used pharmaceutical ingredients that can be used as appropriate to formulate the composition for its intended route of administration include:

acidifying agents (examples include but are not limited to acetic acid, citric acid, fumaric acid, hydrochloric acid, nitric acid);

alkalinizing agents (examples include but are not limited to ammonia solution, ammonium carbonate, diethanolamine, monoethanolamine, potassium hydroxide, sodium borate, sodium carbonate, sodium hydroxide, triethanolamine, trolamine);

adsorbents (examples include but are not limited to powdered cellulose and activated charcoa)I;

aerosol propellants (examples include but are not limited to carbon dioxide, CCI2F2, F₂CIC—CCIF₂ and CCIF₃)

air displacement agents - examples include but are not limited to nitrogen and argon;

antifungal preservatives (examples include but are not limited to benzoic acid, butylparaben, ethylparaben, methylparaben, propylparaben, sodium benzoate);

antimicrobial preservatives (examples include but are not limited to benzalkonium chloride, benzethonium chloride, benzyl alcohol, cetylpyridinium chloride, chlorobutanol, phenol, phenylethyl alcohol, phenylmercuric nitrate and thimerosal);

antioxidants (examples include but are not limited to ascorbic acid, ascorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, hypophosphorus acid, monothioglycerol, propyl gallate, sodium ascorbate, sodium bisulfite, sodium formaldehyde sulfoxylate, sodium metabisulfite);

binding materials (examples include but are not limited to block polymers, natural and synthetic rubber, polyacrylates, polyurethanes, silicones, polysiloxanes and styrene-butadiene copolymers);

buffering agents (examples include but are not limited to potassium metaphosphate, dipotassium phosphate, sodium acetate, sodium citrate anhydrous and sodium citrate dihydrate);

carrying agents (examples include but are not limited to acacia syrup, aromatic syrup, aromatic elixir, cherry syrup, cocoa syrup, orange syrup, syrup, corn oil, mineral oil, peanut oil, sesame oil, bacteriostatic sodium chloride injection and bacteriostatic water for injection);

chelating agents (examples include but are not limited to edetate disodium and edetic acid);

colourants (examples include but are not limited to FD&C Red No. 3, FD&C Red No. 20, FD&C Yellow No. 6, FD&C Blue No. 2, D&C Green No. 5, D&C Orange No. 5, D&C Red No. 8, caramel and ferric oxide red);

clarifying agents (examples include but are not limited to bentonite);

emulsifying agents (examples include but are not limited to acacia, cetomacrogol, cetyl alcohol, glyceryl monostearate, lecithin, sorbitan monooleate, polyoxyethylene 50 monostearate);

encapsulating agents (examples include but are not limited to gelatin and cellulose acetate phthalate),

flavourants (examples include but are not limited to anise oil, cinnamon oil, cocoa, menthol, orange oil, peppermint oil and vanillin);

humectants (examples include but are not limited to glycerol, propylene glycol and sorbitol);

levigating agents (examples include but are not limited to mineral oil and glycerin);

oils (examples include but are not limited to arachis oil, mineral oil, olive oil, peanut oil, sesame oil and vegetable oil);

ointment bases (examples include but are not limited to lanolin, hydrophilic ointment, polyethylene glycol ointment, petrolatum, hydrophilic petrolatum, white ointment, yellow ointment, and rose water ointment);

penetration enhancers (transdermal delivery) (examples include but are not limited to monohydroxy or polyhydroxy alcohols, mono-or polyvalent alcohols, saturated or unsaturated fatty alcohols, saturated or unsaturated fatty esters, saturated or unsaturated dicarboxylic acids, essential oils, phosphatidyl derivatives, cephalin, terpenes, amides, ethers, ketones and ureas),

plasticizers (examples include but are not limited to diethyl phthalate and glycerol);

solvents (examples include but are not limited to ethanol, corn oil, cottonseed oil, glycerol, isopropanol, mineral oil, oleic acid, peanut oil, purified water, water for injection, sterile water for injection and sterile water for irrigation);

stiffening agents (examples include but are not limited to cetyl alcohol, cetyl esters wax, microcrystalline wax, paraffin, stearyl alcohol, white wax and yellow wax);

suppository bases (examples include but are not limited to cocoa butter and polyethylene glycols (mixtures));

surfactants (examples include but are not limited to benzalkonium chloride, nonoxynol 10, oxtoxynol 9, polysorbate 80, sodium lauryl sulfate and sorbitan mono-palmitate);

suspending agents (examples include but are not limited to agar, bentonite, carbomers, carboxymethylcellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, kaolin, methylcellulose, tragacanth and veegum);

sweetening agents (examples include but are not limited to aspartame, dextrose, glycerol, mannitol, propylene glycol, saccharin sodium, sorbitol and sucrose);

tablet anti-adherents (examples include but are not limited to magnesium stearate and talc), tablet binders (examples include but are not limited to acacia, alginic acid, carboxymethylcellulose sodium, compressible sugar, ethylcellulose, gelatin, liquid glucose, methylcellulose, non-crosslinked polyvinyl pyrrolidone, and pregelatinized starch);

tablet and capsule diluents (examples include but are not limited to dibasic calcium phosphate, kaolin, lactose, mannitol, microcrystalline cellulose, powdered cellulose, precipitated calcium carbonate, sodium carbonate, sodium phosphate, sorbitol and starch);

tablet coating agents (examples include but are not limited to liquid glucose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethylcellulose, cellulose acetate phthalate and shellac);

tablet direct compression excipients (examples include but are not limited to dibasic calcium phosphate);

tablet disintegrants (examples include but are not limited to alginic acid, carboxymethylcellulose calcium, microcrystalline cellulose, polacrillin potassium, cross-linked polyvinylpyrrolidone, sodium alginate, sodium starch glycollate and starch);

tablet glidants (examples include but are not limited to colloidal silica, corn starch and talc);

tablet lubricants (examples include but are not limited to calcium stearate, magnesium stearate, mineral oil, stearic acid and zinc stearate);

tablet/capsule opaquants (examples include but are not limited to titanium dioxide); tablet polishing agents (examples include but are not limited to carnuba wax and white wax);

thickening agents (examples include but are not limited to beeswax, cetyl alcohol and paraffin);

tonicity agents (examples include but are not limited to dextrose and sodium chloride); viscosity increasing agents (examples include but are not limited to alginic acid, bentonite, carbomers, carboxymethylcellulose sodium, methylcellulose, polyvinyl pyrrolidone, sodium alginate and tragacanth); and

wetting agents (examples include but are not limited to heptadecaethylene oxycetanol, lecithins, sorbitol monooleate, polyoxyethylene sorbitol monooleate, and polyoxyethylene stearate).

Pharmaceutical compositions according to the present invention can be illustrated as follows:

Sterile i.v. solution: A 5 mg/mL solution of the desired compound of this invention can be made using sterile, injectable water, and the pH is adjusted if necessary. The solution is diluted for administration to 1-2 mg/mL with sterile 5% dextrose and is administered as an i.v. infusion over about 60 minutes.

Lyophilised powder for i.v. administration: A sterile preparation can be prepared with (i) 100-1000 mg of the desired compound of this invention as a lyophilised powder, (ii) 32-327 mg/mL sodium citrate, and (iii) 300-3000 mg Dextran 40. The formulation is reconstituted with sterile, injectable saline or dextrose 5% to a concentration of 10 to 20 mg/mL, which is further diluted with saline or dextrose 5% to 0.2-0.4 mg/mL, and is administered either IV bolus or by IV infusion over 15-60 minutes.

Intramuscular suspension: The following solution or suspension can be prepared, for intramuscular injection:

50 mg/mL of the desired, water-insoluble compound of this invention

5 mg/mL sodium carboxymethylcellulose

4 mg/mL TWEEN 80

9 mg/mL sodium chloride 9 mg/mL benzyl alcohol

Hard Shell Capsules: A large number of unit capsules are prepared by filling standard two-piece hard galantine capsules each with 100 mg of powdered active ingredient, 150 mg of lactose, 50 mg of cellulose and 6 mg of magnesium stearate.

Soft Gelatin Capsules: A mixture of active ingredient in a digestible oil such as soybean oil, cottonseed oil or olive oil is prepared and injected by means of a positive displacement pump into molten gelatin to form soft gelatin capsules containing 100 mg of the active ingredient. The capsules are washed and dried. The active ingredient can be dissolved in a mixture of polyethylene glycol, glycerin and sorbitol to prepare a water miscible medicine mix.

Tablets: A large number of tablets are prepared by conventional procedures so that the dosage unit is 100 mg of active ingredient, 0.2 mg. of colloidal silicon dioxide, 5 mg of magnesium stearate, 275 mg of microcrystalline cellulose, 11 mg. of starch, and 98.8 mg of lactose. Appropriate aqueous and non-aqueous coatings may be applied to increase palatability, improve elegance and stability or delay absorption.

Immediate Release Tablets/Capsules: These are solid oral dosage forms made by conventional and novel processes. These units are taken orally without water for immediate dissolution and delivery of the medication. The active ingredient is mixed in a liquid containing ingredient such as sugar, gelatin, pectin and sweeteners. These liquids are solidified into solid tablets or caplets by freeze drying and solid state extraction techniques. The drug compounds may be compressed with viscoelastic and thermoelastic sugars and polymers or effervescent components to produce porous matrices intended for immediate release, without the need of water.

Dose and Administration

Based upon standard laboratory techniques known to evaluate compounds useful for the treatment of hyper-proliferative disorders and angiogenic disorders, by standard toxicity tests and by standard pharmacological assays for the determination of treatment of the conditions identified above in mammals, and by comparison of these results with the results of known medicaments that are used to treat these conditions, the effective dosage of the compounds of this invention can readily be determined for treatment of each desired indication. The amount of the active ingredient to be administered in the treatment of one of these conditions can vary widely according to such considerations as the particular compound and dosage unit employed, the mode of administration, the period of treatment, the age and sex of the patient treated, and the nature and extent of the condition treated.

The total amount of the active ingredient to be administered will generally range from about 0.001 mg/kg to about 200 mg/kg body weight per day, and preferably from about 0.01 mg/kg to about 20 mg/kg body weight per day. Clinically useful dosing schedules will range from one to three times a day dosing to once every four weeks dosing. In addition, “drug holidays” in which a patient is not dosed with a drug for a certain period of time, may be beneficial to the overall balance between pharmacological effect and tolerability. A unit dosage may contain from about 0.5 mg to about 1500 mg of active ingredient, and can be administered one or more times per day or less than once a day. The average daily dosage for administration by injection, including intravenous, intramuscular, subcutaneous and parenteral injections, and use of infusion techniques will preferably be from 0.01 to 200 mg/kg of total body weight. The average daily rectal dosage regimen will preferably be from 0.01 to 200 mg/kg of total body weight. The average daily vaginal dosage regimen will preferably be from 0.01 to 200 mg/kg of total body weight. The average daily topical dosage regimen will preferably be from 0.1 to 200 mg administered between one to four times daily. The transdermal concentration will preferably be that required to maintain a daily dose of from 0.01 to 200 mg/kg. The average daily inhalation dosage regimen will preferably be from 0.01 to 100 mg/kg of total body weight.

Of course the specific initial and continuing dosage regimen for each patient will vary according to the nature and severity of the condition as determined by the attending diagnostician, the activity of the specific compound employed, the age and general condition of the patient, time of administration, route of administration, rate of excretion of the drug, drug combinations, and the like. The desired mode of treatment and number of doses of a compound of the present invention or a pharmaceutically acceptable salt or ester or composition thereof can be ascertained by those skilled in the art using conventional treatment tests.

Combination Therapies

The compounds of this invention can be administered as the sole pharmaceutical agent or in combination with one or more other pharmaceutical agents where the combination causes no unacceptable adverse effects. Those combined pharmaceutical agents can be other agents having antiproliferative effects such as for example for the treatment of haematological tumours, solid tumours and/or metastases thereof and/or agents for the is treatment of undesired side effects.The present invention relates also to such combinations.

Other anti-hyper-proliferative agents suitable for use with the composition of the invention include but are not limited to those compounds acknowledged to be used in the treatment of neoplastic diseases in Goodman and Gilman's The Pharmacological Basis of Therapeutics (Ninth Edition), editor Molinoff et al., publ. by McGraw-Hill, pages 1225-1287, (1996), which is hereby incorporated by reference, especially (chemotherapeutic) anti-cancer agents as defined supra. The combination can be a non-fixed combination or a fixed-dose combination as the case may be.

Methods of testing for a particular pharmacological or pharmaceutical property are well known to persons skilled in the art.

The example testing experiments described herein serve to illustrate the present invention and the invention is not limited to the examples given.

As will be appreciated by persons skilled in the art, the invention is not limited to the particular embodiments described herein, but covers all modifications of said embodiments that are within the spirit and scope of the invention as defined by the appended claims.

The following examples illustrate the invention in greater detail, without restricting it. Further compounds according to the invention, of which the preparation is not explicitly described, can be prepared in an analogous way.

The compounds, which are mentioned in the examples and the salts thereof represent preferred embodiments of the invention as well as a claim covering all subcombinations of the residues of the compound of formula (I) according to the invention as disclosed by the specific examples.

The term “according to” within the experimental section is used in the sense that the procedure referred to is to be used “analogously to”.

Experimental Part

The following table lists the abbreviations used in this paragraph and in the Intermediate Examples and Examples section as far as they are not explained within the text body.

Abbreviation Meaning AcOH acetic acid (ethanoic acid) ACN acetonitrile aq. aqueous Boc t-butoxycarbonyl br broad Cl chemical ionisation d doublet DAD diode array detector DBU 1,8-Diazabicyclo(5.4.0)undec-7-ene DCM dichloromethane dd double-doublet DIAD diisopropyl (E)-diazene-1,2-dicarboxylate DIPEA N-ethyl-N-isopropylpropan-2-amine DMA Dimethylacetamide DMF N,N-dimethylformamide DMSO dimethyl sulfoxide dt Double-triplet ELSD Evaporative Light Scattering Detector Et₃N N,N-diethylethanamine EtOAc ethyl acetate EtOH ethanol eq. equivalent ESI electrospray (ES) ionisation h hour HATU 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5- b]pyridinium 3-oxid hexafluorophosphate HCl Hydrochloric acid HPLC high performance liquid chromatography KO^(t)Bu Potassium tert-butoxide LC-MS liquid chromatography mass spectrometry m multiplet mCPBA meta-chloroperbenzoic acid min minute MeCN acetonitrile MeOH methanol MS mass spectrometry NaCl Sodium chloride NaHCO₃ Sodium hydrogen carbonate or sodium bicarbonate NMR nuclear magnetic resonance spectroscopy: chemical shifts (δ) are given in ppm. The chemical shifts were corrected by setting the DMSO signal to 2.50 ppm using unless otherwise stated. PDA Photo Diode Array Pd/C Palladium on activated charcoal a quartet r.t. or rt or RT room temperature, typically in a range from 18° C. to 23° C. Rt retention time (as measured either with HPLC or UPLC) in minutes s singlet SIBX Stabilized 2-iodoxybenzoic acid SM starting material SQD Single-Quadrupole-Detector t triplet T3P 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6- trioxide TBAF N,N,N-tributylbutan-1-aminium fluoride td Triple-doublet TEA triethylamine TFA trifluoroacetic acid THF tetrahydrofuran UPLC ultra performance liquid chromatography

Other abbreviations have their meanings customary per se to the skilled person.

The various aspects of the invention described in this application are illustrated by the following examples which are not meant to limit the invention in any way.

A wavy bond

is used in structural formulae to indicate a mixture of stereoisomers at the corresponding chiral center to which it is attached. Alternatively, a simple bond

may also be used in structural formulae to indicate a mixture of stereoisomers at the corresponding chiral center to which it is attached. Stereoisomers which have been isolated are identified as Isomer n (e.g. Isomer 1, Isomer 2) should the absolute configuration of the chiral center not have been determined. Determination of the absolute configuration may be performed by methods known to the skilled person, such as, XRPD of the crystalline enantiomers.

Specific Experimental Descriptions

NMR peak forms in the following specific experimental descriptions are stated as they appear in the spectra, possible higher order effects have not been considered. Reactions employing microwave irradiation may be run with a Biotage Initator® microwave oven optionally equipped with a robotic unit. The reported reaction times employing microwave heating are intended to be understood as fixed reaction times after reaching the indicated reaction temperature. The compounds and intermediates produced according to the methods of the invention may require purification. Purification of organic compounds is well known to the person skilled in the art and there may be several ways of purifying the same compound. In some cases, no purification may be necessary. In some cases, the compounds may be purified by crystallization. In some cases, impurities may be stirred out using a suitable solvent. In some cases, the compounds may be purified by chromatography, particularly flash column chromatography, using for example pre-packed silica gel cartridges, e.g. from Separtis such as (solute® Flash silica gel or (solute® Flash NH₂ silica gel in combination with a Isolera® autopurifier (Biotage) and eluents such as gradients of e.g. hexane/ethyl acetate or DCM/methanol. In some cases, the compounds may be purified by preparative HPLC using for example a Waters autopurifier equipped with a diode array detector and/or on-line electrospray ionization mass spectrometer in combination with a suitable prepacked reverse phase column and eluents such as gradients of water and acetonitrile which may contain additives such as trifluoroacetic acid, formic acid or aqueous ammonia. In some cases, purification methods as described above can provide those compounds of the present invention which possess a sufficiently basic or acidic functionality in the form of a salt, such as, in the case of a compound of the present invention which is sufficiently basic, a trifluoroacetate or formate salt for example, or, in the case of a compound of the present invention which is sufficiently acidic, an ammonium salt for example. A salt of this type can either be transformed into its free base or free acid form, respectively, by various methods known to the person skilled in the art, or be used as salts in subsequent biological assays. It is to be understood that the specific form (e.g. salt, free base etc) of a compound of the present invention as isolated as described herein is not necessarily the only form in which said compound can be applied to a biological assay in order to quantify the specific biological activity.

The percentage yields reported in the following examples are based on the starting component that was used in the lowest molar amount. Air and moisture sensitive liquids and solutions were transferred via syringe or cannula and introduced into reaction vessels through rubber septa. Commercial grade reagents and solvents were used without further purification. The term “concentrated in vacuo” refers to use of a Buchi rotary evaporator at a minimum pressure of approximately 15 mm of Hg. All temperatures are reported uncorrected in degrees Celsius (° C.).

In order that this invention may be better understood, the following examples are set forth. These examples are for the purpose of illustration only and are not to be construed as limiting the scope of the invention in any manner. All publications mentioned herein are incorporated by reference in their entirety.

Analytical LC-MS conditions

LC-MS-data given in the subsequent specific experimental descriptions refer (unless otherwise noted) to the following conditions:

System: Waters Acquity UPLC-MS: Binary Solvent Manager, Sample Manager/Organizer, Column Manager, PDA, ELSD, SQD 3001 or ZQ4000 Column: Acquity UPLC BEH C18 1.7 50 × 2.1 mm Solvent: A1 = water + 0.1% vol. formic acid (99%) A2 = water + 0.2% vol. ammonia (32%) B1 = acetonitrile Gradient: 0-1.6 min 1-99% B, 1.6-2.0 min 99% B Flow: 0.8 mL/min Temperature 60° C. Injection: 2.0 μl Detection: DAD scan range 210-400 nm -> Peaktable ELSD Methods: MS ESI+, ESI− Switch -> various scan ranges (Report Header Method 1: A1 + B1 = C:\MassLynx\Mass_100_1000.flp Method 2: A1 + B1 = C:\MassLynx\ NH₃_Mass_100_1000.flp

Preparative HPLC Conditions

“Purification by preparative HPLC” in the subsequent specific experimental descriptions refers to (unless otherwise noted) the following conditions:

Analytics (Pre- and Post Analytics: Method A):

System: Waters Acquity UPLC-MS: Binary Solvent Manager, Sample Manager/Organizer, Column Manager, PDA, ELSD, SQD 3001 Column: Acquity BEH C18 1.7 50 × 2.1 mm Solvent: A = water + 0.1% vol. formic acid (99%) B = acetonitrile Gradient: 0-1.6 min 1-99% B, 1.6-2.0 min 99% B Flow: 0.8 mL/min Temperature: 60° C. Injection: 2.0 μl Detection: DAD scan range 210-400 nm MS ESI+, ESI−, scan range 160-1000 m/z ELSD Methods: Purify_pre.flp Purify_post.flp

Analytics (Pre- and Post Analytics: Method B):

System: Waters Acquity UPLC-MS: Binary Solvent Manager, Sample Manager/Organizer, Column Manager, PDA, ELSD, SQD 3001 Column: Acquity BEH C18 1.7 50 × 2.1 mm Solvent: A = water + 0.2% vol. ammonia (32%) B = acetonitrile Gradient: 0-1.6 min 1-99% B, 1.6-2.0 min 99% B Flow: 0.8 mL/min Temperature: 60° C. Injection: 2.0 μl Detection: DAD scan range 210-400 nm MS ESI+, ESI−, scan range 160-1000 m/z ELSD Methods: Purify_pre.flp Purify_post.flp

Preparative HPLC (Method Acidic):

System: Waters Autopurificationsystem: Pump 2545, Sample Manager 2767, CFO, DAD 2996, ELSD 2424, SQD 3001 Column: XBridge C18 5 μm 100 × 30 mm Solvent: A = water + 0.1% vol. formic acid (99%) B = acetonitrile Gradient: 0-1 min 1% B, 1-8 min 1-99% B, 8-10 min 99% B Flow: 50 mL/min Temperature: RT Solution: max. 250 mg/2.5 mL dimethyl sufoxide or DMF Injection: 1 × 2.5 mL Detection: DAD scan range 210-400 nm MS ESI+, ESI−, scan range 160-1000 m/z

Preparative HPLC (Method Basic):

System: Waters Autopurificationsystem: Pump 2545, Sample Manager 2767, CFO, DAD 2996, ELSD 2424, SQD 3001 Column: XBridge C18 5 μm 100 × 30 mm or Chromatorex RP C-18 10 μm 125 * 30 mm Solvent: A = water + 0.2% vol. ammonia (32%) B = acetonitrile Gradient: 0-1 min 1% B, 1-8 min 1-99% B, 8-10 min 99% B Flow: 50 mL/min Temperature: RT Solution: max. 250 mg/2.5 mL dimethyl sufoxide or DMF Injection: 1 × 2.5 mL Detection: DAD scan range 210-400 nm MS ESI+, ESI−, scan range 160-1000 m/z

Preparative HPLC (Method Chiral):

System: Labomatic Pumpe: HD-5000, Labomatic SP-3000, Labocord 5000, Labomatic Labcol Vario 4000, Gilson GX-241, Column: Chiralpak IB 5 μm 250 × 30 mm Solvent: A = ACN + 0.1% DEA B = EtOH Flow: 50 mL/min Temperature: RT Detection: MWD 280 nm

Flash Column Chromatography Conditions

“Purification by (flash) column chromatography” as stated in the subsequent specific experimental descriptions refers to the use of a Biotage Isolera purification system. For technical specifications see “Biotage product catalogue” on www.biotage.com.

EXAMPLES Example 1 (6RS)-6-(Hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 1-3: (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide

To a solution of (5RS)-5({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-hydroxycyclohex-2-en-1-one (20.0 g, 52.6 mmol; can be prepared according to EP 2617720) and phenylisothiocyanate (6.29 mL, 52.6 mmol) in MeCN (90 mL) was added DBU (13.3 mL, 89.3 mmol) at 3° C. and the mixture was stirred at RT for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, EtOAc:Hexane) to give the title compound (20.1 g, 74%).

1-2: (4RS)-4({[tert-Butyl(diphenyl)silyl]oxy}methyl)-6-oxo-N-phenyl-2-[(pyridin-4-ylmethypamino]cyclohex-1-ene-1-carbothioamide

A solution of (4RS)-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide (3-3; 20.1 g, 39.0 mmol) and 4-(methylamino)pyridine (7.92 mL, 77.9 mmol) in DMA (110 mL) was heated at 100° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, EtOAc:Hexane) to give the title compound (11.0 g, 67%).

1-1: 3-Anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide (3-2; 11.0 g, 18.2 mmol), SIBX (45%, 11.3 g, 18.2 mmol) in EtOH (540 mL) was stirred at Rt for 16 h. Et₃N (6 mL) were added, the mixture was concentrated and purified by Biotage (SNAP silica 375 g, EtOH:DCM) to give the title compound (7.70 g, 74%).

(6RS)-6-(Hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of 3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (3-1; 10.0 g, 17.5 mmol) and TBAF (22.7 mL, 1M in THF) in THF (250 mL) was stirred at RT for 16 h. EtOAc (1 L) was added, the mixture washed with sodium hydroxide (2.5% in water), brine and dried over sodium sulfate. After filtration and removal of the solvent the residue was purified by Biotage (SNAP silica 340 g, MeOH:DCM) to give the title compound (4.31 g, 74%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.20-2.37 (3H), 2.55 (1H), 2.96 (1H), 3.44 (2H), 4.76 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.41 (2H), 11.91 (1H)

Example 2 tert-Butyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate 2-2: tert-Butyl {[(1 RS)-3-hydroxy-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-en-1-yl]methyl}carbamate

To a solution of tert-butyl {[(1RS)-3-hydroxy-5-oxocyclohex-3-en-1-yl]methyl}carbamate (1.00 g, 4.14 mmol; commercially available from FCH Group Company) and phenylisothiocyanate (496 μL, 4.14 mmol) in MeCN (50 mL) was added DBU (619 μL, 4.14 mmol) and the mixture was stirred at RT for 16 h. Ethyl acetate was added, the mixture extracted with hydrochloric acid (1 M), washed with water and brine and dried over sodium sulfate. After filtration the mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (353 mg, 23%).

2-1: tert-Butyl ({(1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-en-1-yl}methyl)carbamate

A solution of tert-butyl [(6R⁵)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate (2-2; 353 mg, 938 μmol) and 4-(methylamino)pyridine (228 μL, 2.25 mmol) in EtOH (20 mL) and EtOAc (20 mL) was heated at 90° C. for 6 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (84 mg, 19%).

tert-Butyl [(6RS-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate

A mixture of tert-butyl ({(1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-en-1-yl}methyl)carbamate (2-1; 80 mg, 171 μmol), hydrogen peroxide (34% in water, 31 μL, 343 μmol) in DMSO (1 mL) was heated at 90° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (20 mg, 27%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.40 (9H), 2.20-2.33 (2H), 2.59-2.65 (2H), 2.92 (1H), 3.04 (2H), 6.57 (2H), 6.83 (1H), 7.04 (3H), 7.42 (1H), 7.46 (2H), 8.41 (2H), 11.91 (1H)

Example 3 (6RS)-6-[(Benzyloxy)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 3-2: (4RS)-4-[(Benzyloxy)methyl]-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide

To a solution of (5RS)-5-[(benzyloxy)methyl]-3-hydroxycyclohex-2-en-1-one (350 mg, 1.51 mmol; can be prepared according to Archie der Pharmazie, 1979 , 312 (3), p. 240-247) and phenylisothiocyanate (200 μL, 1.67 mmol) in MeCN (1 mL) was added DBU (300 μL, 2.01 mmol) and the mixture was stirred at RT for 18 h. Hydrochloric acid (1 M) was added, the mixture extracted with diethyl ether, washed with water and brine and dried over sodium sulfate. After filtration the mixture was concentrated and purified by column chromatography on silica (DCM) to give the title compound (420 mg, 76%).

3-1: (4RS)-4-[(Benzyloxy)methyl]-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide

A solution of (4RS)-4-[(benzyloxy)methyl]-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide (3-2; 400 mg, 1.09 mmol) and 4-(methylamino)pyridine (130 mg, 1.20 mmol) in EtOH (2 mL) was heated at 100° C. for 3 h. The mixture was concentrated and purified by column chromatography on silica (EtOAc) to give the title compound (340 mg, 68%).

(6RS)-6-[(Benzyloxy)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (4RS)-4-[(benzyloxy)methyl]-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide (3-1; 300 mg, 656 μmol), hydrogen peroxide (35% in water, 120 μL, 1.37 mmol) in EtOH (1 mL) was heated at 80° C. for 10 minutes. The mixture was concentrated and purified by column chromatography on silica (EtOAc:diethyl ether) to give the title compound (66 mg, 21%).

¹H NMR (400 MHz, CDCI₃) δ ppm 2.25 (2H), 2.50 (1H), 2.68 (1H), 2.98 (1H), 3.41 (2H), 4.45 (2H), 6.51 (2H), 6.56 (1H), 6.97 (2H), 7.20-7.42 (8H), 8.34 (2H), 11.83 (1H)

Example 4 tert-Butyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]carbamate 4-4: tert-Butyl (3,5-dihydroxyphenyl) carbamate

To a stirred solution of 5-aminoresorcinol (75 g, 600 mmol; CAS-No 20734-67-2) in THF (1.5 L) was added TEA (102 mL, 720 mmol) at room temperature and then (Boc)₂O (130.8 g, 600 mmol) was added slowly drop wise. The reaction mixture was stirred for 16 h at room temperature. After completion of reaction (TLC), the reaction mixture was concentrated under vacuum and then water was added to residue, extracted with ethyl acetate. The combined organic layer was dried over to Na₂SO₄ and concentrated to afford the desired product after silica chromatography (68 g, 51%).

4-3: tert-Butyl [(1RS)-3-hydroxy-5-oxocyclohex-3-en-1-yl]carbamate

To a compound 3 (50 g) in 0.1M NaOH solution (500 mL) was added 10% Pd/C (15 g) at room temperature using a Parr apparatus. The reaction mass was hydrogenated with H2 (250 psi) at 60 eC for 16 h. After completion of reaction (TLC), the reaction mixture was filtered through celite bed and filtrate was extracted with ethyl acetate. The combined organic layer was dried over to Na₂SO₄ and concentrated to afford crude product. The solid residue was recrystallized in diethyl ether to obtained the desired product (7.0 g, 14%).

4-2: tert-Butyl [(1RS)-3-hydroxy-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-en-1-yl]carbamate

To a solution of tert-butyl [(1RS)-3-hydroxy-5-oxocyclohex-3-en-1-yl]carbamate (4-3; 5.0 g, 22.0 mmol) and phenylisothiocyanate (2.63 mL, 22.0 mmol) in MeCN (50 mL) was added DBU (7.50 mL, 50.3 mmol) at 3° C. and the mixture was stirred a t RT for 64 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, EtOAc:Hexane) to give the title compound (4.02 g, 50%).

4-1: tert-Butyl {(1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-en-1-yl}carbamate

A solution of tert-butyl [(1RS)-3-hydroxy-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-en-1-yl]carbamate (4-2; 1.33 g, 3.67 mmol) and 4-(methylamino)pyridine (731 μL, 7.34 mmol) in DMA (10 mL) was heated at 130° C. for 2 h. The mixture wa s concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (945 mg, 57%).

tert-Butyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]carbamate

A mixture of tert-butyl {(1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-en-1-yl}carbamate (4-1; 940 mg, 2.08 mmol), hydrogen peroxide (34% in water, 374 μL, 4.15 mmol) in MeOH (50 mL) was heated at 80° C. for 6 h. T he mixture was concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (600 mg, 69%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.41 (9H), 2.39-2.49 (2H), 2.81 (1H), 3.15 (1H), 4.02 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.28 (1H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.97 (1H)

Example 5 (6RS)-6-Amino-3-anilino-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one hydrochloride

A mixture of tert-butyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]carbamate (4; 400 mg, 956 μmol) and HCl in dioxane (10 mL, 1M) was stirred at RT for 1 h. The mixture was concentrated to give the title compound (412 mg, crude).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.73 (2H), 3.14 (1H), 3.48 (1H), 3.94 (1H), 6.72 (2H), 6.76 (1H), 7.13 (2H), 7.89 (2H), 8.04 (1H), 8.48 (3H), 8.63 (2H), 13.16 (1H)

Example 6 N-[(6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]cyclopropanecarboxamide

A mixture of 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 83 mg, 212 μmol) and cyclopropanecarbonyl chloride (39 μL, 424 μmol) in pyridine (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic Method) to give the title compound (26 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.61-0.73 (4H), 1.57 (1H), 2.42-2.56 (2H), 2.87 (1H), 3.17 (1H), 4.33 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.45 (1H), 7.47 (2H), 8.42 (2H), 8.45 (1H), 11.97 (1H)

Example 7 (6RS)-4-Oxo-N-phenyl-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide 7-2: (1RS)-3-hydroxy-5-oxo-N-phenyl-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxamide

To a solution of methyl (1RS)-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate (630 mg, 3.70 mmol; commercially available from FCH Group Company) and phenylisothiocyanate (443 μL, 3.72 mmol) in MeCN (5.7 mL) was added DBU (867 μL, 5.81 mmol) at 3° C. and the mixture was stirred at RT for 24 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (93 mg, 7%).

7-1: (1RS)-5-Oxo-N-phenyl-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxamide

A solution of (1RS)-3-hydroxy-5-oxo-N-phenyl-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxamide (7-2; 90 mg, 246 μmol) and 4-(methylamino)pyridine (50 μL, 491 μmol) in DMA (800 μL) was heated at 120° C. for 1.5 h. The mixture was concentrated and purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (67 mg, 60%). (6RS)-4-Oxo-N-phenyl-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture of (1RS)-5-oxo-N-phenyl-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxamide (7-1; 65 mg, 142 μmol), hydrogen peroxide (34% in water, 26 μL, 285 μmol) in MeOH (5 mL) was heated at 80° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (14 mg, 23%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.52-2.57 (2H), 2.65 (1H), 3.14 (2H), 6.59 (2H), 6.64 (1H), 7.01-7.09 (3H), 7.32 (2H), 7.46 (1H), 7.48 (2H), 7.62 (2H), 8.43 (2H), 10.07 (1H), 12.00 (1H)

Example 8 Methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 8-2: Methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate

To a solution of methyl (1RS)-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate (630 mg, 3.70 mmol; commercially available from FCH Group Company) and phenylisothiocyanate (443 μL, 3.72 mmol) in MeCN (5.7 mL) was added DBU (867 μL, 5.81 mmol) at 3° C. and the mixture was stirred at RT for 24 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (216 mg, 19%).

8-1: Methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate (8-2; 3.00 g, 9.83 mmol) and 4-(methylamino)pyridine (2.0 mL, 19.6 mmol) in dioxane (15 mL) was heated at 1200 for 1.5 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, MeOH:DCM) to give the title compound (2.71 g, 70%).

Methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate (8-1; 2.70 mg, 6.83 mmol), hydrogen peroxide (34% in water, 1.23 mL, 13.7 mmol) in MeOH (50 mL) was heated at 80C for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (1.42 g, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.56-2.62 (2H), 3.09-3.21 (2H), 3.37 (1H), 3.64 (3H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44-7.49 (3H), 8.42 (2H), 12.00 (1H)

Example 9 (6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (8; 2.70 g, 7.47 mmol), potassium hydroxide (29.9 mL, 4M in water), THF (29.7 mL) and MeOH (29.7 mL) was stirred at RT for 10 minutes. Hydrochloric acid (39.8 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (2.52 g, 97%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.60 (2H), 3.17 (2H), 3.27 (1H), 6.63 (2H), 6.69 (1H), 7.08 (2H), 7.63 (2H), 7.77 (1H), 8.50 (2H), 12.39 (1H), 12.65 (1H)

Example 10 (6RS)-N-Methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (2 mL), DIPEA (75 μL, 432 μmol), N-methanamine (216 μL, 2M in THF) and T3P (130 μL, 50% in DMF) was stirred at RT for 3 days. The mixture was concentrated, EtOAc was added, washed with sodium hydrogencarbonate, filtered and dried to give the title compound (40 mg, 73%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.38 (1H), 2.55 (1H), 2.61 (3H), 2.95-3.11 (3H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (2H), 7.48 (1H), 7.95 (1H), 8.41 (2H), 11.97 (1H)

Example 11 (6RS)-4-Oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 47 mg, 134 μmol), DMF (2 mL), DIPEA (70 μL, 401 μmol), propan-1-amine (33 μL, 402 μmol) and T3P (121 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was concentrated, DCM was added, washed with sodium hydrogencarbonate, filtered and dried to give the title compound (34 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.86 (3H), 1.42 (2H), 2.38 (1H), 2.55 (1H), 2.95-3.11 (5H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (2H), 7.47 (1H), 7.98 (1H), 8.42 (2H), 11.97 (1H)

Example 12 (6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (2 mL), DIPEA (75 μL, 432 μmol), ammonia (863 μL, 0.5 M in water) and T3P (130 μL, 50% in DMF) was stirred at RT for 3 days. The mixture was concentrated, EtOAc was added, washed with sodium hydrogencarbonate, filtered and dried to give the title compound (40 mg, 76%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.41 (1H), 2.54 (1H), 2.98-3.11 (3H), 6.58 (2H), 6.63 (1H), 7.01 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 7.49 (1H), 8.41 (2H), 12.00 (1H)

Example 13 (6RS)-N-(2-Hydroxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (2 mL), DIPEA (75 μL, 432 μmol), N-methanamine (216 μL, 2M in THF) and T3P (65 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was concentrated, washed with sodium hydrogencarbonate, filtered and dried to give the title compound (34 mg, 54%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.38 (1H), 2.54 (1H), 2.97-3.19 (5H), 3.41 (2H), 4.75 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.07 (1H), 8.41 (2H), 12.07 (1H)

Example 14 Methyl (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 14-1: methyl (1RS)-3-{[(3-fluoropyridin-4-yl)methyl]amino}-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate (8-2; 900 mg, 2.95 mmol) and 1-(3-fluoropyridin-4-yl)methanamine (630 μL, 5.89 mmol) in DMA (9 mL) was heated at 120° C. for 1.5 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (524 mg, 41%).

Methyl (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-{[(3-fluoropyridin-4-yl)methyl]amino}-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (14-1; 500 mg, 1.21 mmol), hydrogen peroxide (34% in water, 218 μL, 2.42 mmol) in MeOH (25 mL) was heated at 80° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (230 mg, 50%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.61 (2H), 3.15 (2H), 3.39 (1H), 3.65 (3H), 6.55 (2H), 6.60 (1H), 6.99 (2H), 7.40 (1H), 7.55 (1H), 8.25 (1H), 8.51 (1H), 11.73 (1H)

Example 15 Methyl (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 15-1: methyl (1RS)-3-{[(3-methoxypyridin-4-yl)methyl]amino}-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate (8-2; 900 mg, 2.95 mmol) and 1-(3-methoxypyridin-4-yl)methanamine (814 mg, 5.89 mmol) in DMA (9 mL) was heated at 120° C. for 1. 5 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (754 mg, 57%).

Methyl (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-{[(3-methoxypyridin-4-yl)methyl]amino}-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (15-1; 720 mg, 1.69 mmol), hydrogen peroxide (34% in water, 305 μL, 3.38 mmol) in MeOH (33 mL) was heated at 80° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (234 mg, 35%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.59 (2H), 3.11 (1H), 3.20 (1H), 3.36 (1H), 3.65 (3H), 3.89 (3H), 6.52 (2H), 6.58 (1H), 6.98 (2H), 7.31 (1H), 7.41 (1H), 8.01 (1H), 8.35 (1H), 11.40 (1H)

Example 16 (6RS)-N-(2-Methoxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), 2-methoxyethanamine (53 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (45 mg, 53%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.37 (1H), 2.54 (1H), 2.97-3.16 (3H), 3.24 (2H), 3.26 (3H), 3.36 (2H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 8.11 (1H), 8.42 (2H), 11.96 (1H)

Example 17 (6RS)-N-(2-Hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), 2-(methylamino)ethanol (49 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (53 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.30-2.38 (1H), 2.46-2.57 (1H), 2.86+3.10 (3H), 2.92-3.07 (2H), 3.28-3.55 (4H), 3.64+3.72 (1H), 4.69+4.86 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.42-7.48 (3H), 8.41 (2H), 11.96 (1H)

Example 18 (6RS)-N-Ethyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), N-methylethanamine (52 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (56 mg, 67%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.02+1.13 (3H), 2.25-2.36 (1H), 2.46-2.59 (1H), 2.83+3.04 (3H), 2.94 (1H), 3.04 (1H), 3.22-3.47 (2H), 3.61 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.95 (1H)

Example 19 (6RS)-6-(Morpholin-4-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), morpholine (53 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (65 mg, 73%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.54 (1H), 2.96 (1H), 3.05 (1H), 3.48 (2H), 3.58 (6H), 3.66 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.97 (1H)

Example 20 (6RS)-3-(Phenylamino)-2-(pyridin-4-yl)-6-(pyrrolidin-1-ylcarbonyl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), pyrrolidine (50 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (60 mg, 71%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.79 (2H), 1.89 (2H), 2.36 (1H), 2.52 (1H), 2.96 (1H), 3.05 (1H), 3.21-3.32 (2H), 3.44 (1H), 3.52 (2H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43 (1H), 7.47 (2H), 8.42 (2H), 11.96 (1H)

Example 21 (6RS)-6-(Azetidin-1-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), azetidine (41 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (44 mg, 54%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.20 (2H), 2.32 (1H), 2.47 (1H), 2.89-3.01 (2H), 3.20 (1H), 3.87 (2H), 4.21 (2H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.42 (1H), 7.47 (2H), 8.42 (2H), 11.97 (1H)

Example 22 (6RS)-N-(Cyclopropylmethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), 1-cyclopropylmethanamine (52 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (57 mg, 67%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.16 (2H), 0.41 (2H), 0.96 (1H), 2.38 (1H), 2.56 (1H), 2.95-3.14 (5H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 8.08 (1H), 8.41 (2H), 11.96 (1H)

Example 23 (6RS)-N-(Cyclopropylmethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), 1-cyclopropyl-N-methylmethanamine (58 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (58 mg, 66%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.21+0.26 (2H), 0.44+0.50 (2H), 0.96 (1H), 2.26-2.37 (1H), 2.45-2.58 (1H), 2.91+3.11 (3H), 2.92-3.08 (2H), 3.21 (1H), 3.31 (1H), 3.65 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.94 (1H)

Example 24 (6RS)-N-Methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-y0-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), N-methylpropan-1-amine (62 μL, 605 μmol) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (63 mg, 74%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.81+0.86 (3H), 1.47+1.55 (2H), 2.24-2.36 (1H), 2.47-2.59 (2H), 2.83+3.04 (3H), 2.89-3.08 (2H), 3.19-3.36 (1H), 3.64 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.95 (1H)

Example 25 (6RS)-N,N-Dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), N-methylmethanamine (302 μL, 2M in THF) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (53 mg, 67%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.46 (1H), 2.85 (3H), 2.95 (1H), 3.03 (1H), 3.07 (3H), 3.66 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.96 (1H)

Example 26 (6RS)-N-Ethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 70 mg, 202 μmol), DMF (2 mL), DIPEA (105 μL, 605 μmol), ethanamine (302 μL, 2M in THF) and T3P (181 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (25 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (3H), 2.38 (1H), 2.55 (1H), 2.95-3.15 (5H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.47 (2H), 7.99 (1H), 8.41 (2H), 11.96 (1H)

Example 27 (6RS)-N-tert-Butyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (2 mL), DIPEA (75 μL, 432 μmol), 2-methylpropan-2-amine (45 μL, 432 μmol) and T3P (65 μL, 50% in DMF) was stirred at RT for 3 days. The mixture was concentrated, sodium hydrogencarbonate was added, the precipitate filtered and purified by preparative HPLC (basic method) to give the title compound (5 mg, 8%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.27 (9H), 2.33 (1H), 2.50 (1H), 2.89-3.10 (3H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.59 (1H), 8.41 (2H), 11.95 (1H)

Example 28 (6RS)-3-(Phenylamino)-6-(piperidin-1-ylcarbonyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (2 mL), DIPEA (75 μL, 432 μmol), piperidine (43 μL, 432 mmol) and T3P (130 μL, 50% in DMF) was stirred at RT for 3 days. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (16 mg, 25%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.44 (2H), 1.52 (2H), 1.60 (2H), 2.29 (1H), 2.54 (1H), 2.94 (1H), 3.04 (1H), 3.46 (2H), 3.49 (2H), 3.66 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.95 (1H)

Example 29 (6RS)-4-Oxo-3-(phenylamino)-N-(propan-2—O—2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (2 mL), DIPEA (75 μL, 432 μmol), propan-2-amine (37 μL, 432 μmol) and T3P (65 μL, 50% in DMF) was stirred at RT for 3 days. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (18 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.06 (6H), 2.36 (1H), 2.54 (1H), 2.92-3.07 (3H), 3.84 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 7.85 (1H), 8.42 (2H), 11.95 (1H)

Example 30 (6RS)-6-(Hydroxymethyl)-6-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 30-3: (4RS)-4({[tert-Butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenyl-2-[(pyridin-4-ylmethypamino]cyclohex-1-ene-1-carbothioamide

To a solution of (5RS)-5({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-hydroxy-5-methylcyclohex-2-en-1-one (5.00 g, 12.7 mmol; can be prepared according to Synthesis, 2014, 46 (3), 381-386) and phenylisothiocyanate (1.52 mL, 12.7 mmol) in MeCN (25 mL) was added DBU (1.89 mL, 12.7 mmol) at 3° C. and the mixture was stirred at RT for 2.5 days. The mixture was poured into water, extracted with EtOAc, washed with brine and dried over sodium sulfate. After filtration the mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (5.18 g, 77%).

30-2: (4RS)-4({[tert-Butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide

A solution of (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide (30-3; 3.33 g, 6.29 mmol) and 4-(methylamino)pyridine (894 μL, 8.80 mmol) in DMA (16.7 mL) was heated at 80° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (1.78 g, 43%).

30-1: (6RS)-3-Anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-methyl-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide (30-2; 1.41 g, 2.28 mmol), SIBX (45%, 1.70 g, 2.73 mmol) in MeOH (32 mL) and DCM (85 mL) was stirred at RT for 1 h. The mixture was poured into saturated sodium hydrogencarbonate, extracted with DCM and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 100 g, EtOAc:DCM) to give the title compound (662 mg, 50%).

(6RS)-6-(Hydroxymethyl)-6-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-methyl-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (30-1; 3.1 g, 5.29 mmol) and TBAF (7.94 mL, 1M in THF) in THF (75 mL) was stirred at 60° C. for 16 h. EtOAc (1 L) was added, the mixture washed with sodium hydroxide (2.5% in water), brine and dried over sodium sulfate. After filtration and removal of the solvent the residue was purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (800 mg, 41%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.98 (3H), 2.08 (1H), 2.38 (1H), 2.59 (1H), 2.97 (1H), 3.27 (2H), 4.89 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.41 (2H), 11.87 (1H)

Example 31 methyl (6RS)-2-(2-Aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 31-1: methyl (1RS)-3-{[(2-aminopyridin-4-yl)methyl]amino}-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethypamino]cyclohex-3-ene-1-carboxylate (8-2; 6.00 g, 19.6 mmol) and 4-(aminomethyl)pyridin-2-amine (4.84 g, 39.3 mmol) in DMA (30 mL) was heated at 130° C. for 1.5 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, MeOH:DCM) to give the title compound (4,12 g, 51%).

Methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-{[(2-aminopyridin-4-yl)methyl]amino}-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (31-1; 4.11 g, 10.0 mmol), hydrogen peroxide (34% in water, 1.81 mL, 20.0 mmol) in MeOH (103 mL) was heated at 90° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 110 g, MeOH:DCM) to give the title compound (2.40 g, 64%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.52-2.62 (2H), 3.07 (1H), 3.14 (1H), 3.33 (1H), 3.34 (3H), 5.76 (2H), 6.55 (2H), 6.57 (1H), 6.60 (1H), 6.68 (1H), 7.02 (2H), 7.24 (1H), 7.77 (1H), 11.79 (1H)

Example 32 (6RS)-6-(Azidomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 32-1: [(6RS)-3-Anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate

A mixture of (6RS)-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (1; 2.00 g, 6.00 mmol), methanesulfonyl chloride (557 μL, 7.20 mmol) in pyridine (32 mL) was stirred at RT for 4 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 110 g, MeOH:DCM) to give the title compound (2.16 g, 88%).

(6RS)-6-(Azidomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 1.00 g, 2.43 mmol), sodium azide (1.58 g, 24.3 mmol) in DMA (40 mL) was stirred at 80° C. for 2 days. After filtration, the mixture was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (865 mg, 99%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.26-2.40 (2H), 2.45-2.55 (1H), 2.71 (1H), 3.02 (1H), 3.51 (2H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.42 (2H), 11.96 (1H)

Example 33 (6RS)-6-[(Dimethylamino)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 50 mg, 122 μmol), N-methylmethanamine (243 μL, 2M in THF) in DMA (1 mL) was stirred at 60C for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (11 mg, 25%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.15 (6H), 2.17-2.24 (2H), 2.27-2.47 (3H), 2.58 (1H), 3.01 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.91 (1H)

Example 34 (6RS)-6-(Hydroxymethyl)-1-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (1; 50 mg, 150 μmol), DIAD (47 μL, 240 μmol), triphenylphosphine (63 mg, 240 μmol), MeOH (30 μL, 750 μmol) in THF (3 mL) was stirred at RT for 2.5 days. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (18 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.23-2.37 (3H), 2.64 (1H), 3.02 (1H), 3.47 (2H), 3.57 (3H), 4.79 (1H), 6.47 (2H), 6.52 (1H), 6.94 (2H), 7.22 (1H), 7.35 (2H), 8.50 (2H)

Example 35 (6RS)-6-[tert-Butyl(dimethyl)silyl]oxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 35-4: (5RS)-5-hydroxycyclohex-2-en-1-one

A solution of benzene-1,3,5-triol (100 g, 792.96 mmol) and NaOH (31.72 g, 792.96 mmol) in H2O (1.5 L) was added Rh-Al (10%, 2 g). The mixture was stirred for 14 hours at 30° C. under H 2 (60 psi). TLC (DCM: MeOH =15:1) indicated the starting material was consumed completely. The solid was filtered and the filtrate was concentrated. The residue was purified by silica gel chromatography eluted with DCM: MeOH =10:1 to give crude 5-hydroxycyclohexane-1,3-dione (120 g) as a yellow solid.

1H NMR (400 MHz, CDCl3): δ ppm 4.18-4.15. (m, 1H), 3.35 (s, 3 H), 2.58-2.52 (m, 2H), 2.35-2.29 (m, 2H).

35-3: (5RS)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxycyclohex-2-en-1-one

To a solution of crude 5-hydroxycyclohexane-1,3-dione (35-4; 130 g) in DMF (800 mL) was added NaH (80.8 g, 2.02 mol) in one portion at −5° C. unde r N2. The mixture was stirred at −5° C. for 10 min. Then TBSCI (229.39 g, 1.52 mol) in DMF (200 mL) was added at -5 C. The mixture was stirred for another 14 hr at 15 C. TLC indicated the reaction completed. The mixture was cooled to 1° C. and quenched by water at 0° C. The aqueous pha se was extracted with EA (1 L). The aqueous phase was adjusted to pH 5˜6 with aq. HCl (1M). The solid was filtered to give 5-[tert-butyl(dimethyl) silyl]oxycyclohexane-1,3-dione (40 g) as a white solid.

1H NMR (400 MHz, CDCI3): δ ppm 4.52-4.50. (m, 1H), 3.49-3.32 (m, 2H), 2.81-2.66 (m, 4 H), 0.83 (s, 6 H), 0.07 (s, 6 H).

35-2: (4RS)-4-{[tert-Butyl(dimethyl)silyl]oxy}-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide

To a solution of (5RS)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxycyclohex-2-en-1-one (35-3; 1.00 g, 4.13 mmol) and phenylisothiocyanate (494 μL, 4.13 mmol) in MeCN (10 mL) was added DBU (1.40 mL, 9.38 mmol) at 3° C. and the mixture was stirred a t RT for 1 h. The mixture was poured into ice cold water, acidified with hydrochloric acid, extracted with EtOAc, washed with brine and dried over sodium sulfate. After filtration the mixture was concentrated and purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (386 mg, 25%).

35-1: (4RS)-4-{[tert-Butyl(dimethyl)silyl]oxy}-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide

A solution of (4RS)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide (35-2; 235 mg, 622 μmol) and 4-(methylamino)pyridine (124 μL, 1.24 mmol) in EtOH (5 mL) and EtOAc (5 mL) was heated at 90° C. for 6 h. The mixture was concentrated and purified by Biotage (SNAP silica 25 g, EtOAc:Hexane) to give the title compound (113 mg, 39%).

(6RS)-6-[tert-Butyl(dimethypsily]oxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (4RS)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide (35-1; 106 mg, 226 μmol), hydrogen peroxide (34% in water, 41 μL, 453 μmol) in EtOH (5 mL) was heated at 90° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (70 mg, 71%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.08 (3H), 0.09 (3H), 0.84 (9H), 2.42 (1H), 2.55 (1H), 2.86 (1H), 3.17 (1H), 4.48 (1H), 6.57 (2H), 6.62 (1H), 7.03 (2H), 7.44 (1H), 7.47 (2H), 8.42 (2H), 11.94 (1H)

Example 36 (6RS)-6-(Aminomethyl)-3-(phenylamino)-2-(pyridin-4-y0-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-6-(azidomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (32; 801 mg, 2.24 mmol), triphenylphosphine (1.31 g, 4.98 mmol) ammonia (4.78 mL, 25% in water) in THF (35 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 28 g, MeOH:DCM) to give the title compound (722 mg, 96%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.13-2.27 (2H), 2.37 (1H), 2.59-2.69 (3H), 2.97 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.40 (2H), 11.90 (1H)

Example 37 (6RS)-1-Ethyl-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (1; 50 mg, 150 μmol), DIAD (47 μL, 240 μmol), triphenylphosphine (63 mg, 240 μmol), EtOH (1 mL) in THF (3 mL) was stirred at 80° C. for 2.5 days. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (6 mg, 10%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.15 (3H), 2.21-2.37 (3H), 2.68 (1H), 3.04 (1H), 3.48 (2H), 4.00 (2H), 4.79 (1H), 6.45 (2H), 6.51 (1H), 6.93 (2H), 7.16 (1H), 7.32 (2H), 8.52 (2H)

Example 39 (6RS)-6-Hydroxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-6-[tert-butyl(dimethyl)silyl]oxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (35; 64 mg, 148 μmol) and TBAF (295 μL, 1M in THF) in THF (10 mL) was stirred at RT for 4 h. The mixture was poured into saturated sodium hydrogencarbonate, extracted with EtOAc, washed with brine and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 10 g, MeOH:DCM) to give the title compound (48 mg, max 100%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.39 (1H), 2.55 (1H), 2.83 (1H), 3.13 (1H), 4.29 (1H), 5.20 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.92 (1H)

Example 40 (6RS)-6-Ethenyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one 40-1: (6RS)-3-Anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carbaldehyde

A solution of ethanedioyl dichloride (196 μL, 2.25 mmol) in DCM (6 mL) was cooled to −78° C. DMSO (319 μL, 4.50 mmol) was added slowly followed by a solution of (6RS)-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (1; 300 mg, 900 μmol) in DCM (6 mL) and DMSO (1.2 mL). The mixture was stirred at −78° C. for 1 h, Et₃N (1.0 mL) was added and the mixture warmed to RT. Water was added, the mixture extracted with DCM/MeOH and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (158 mg, 53%).

(6RS)-6-Ethenyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

To a solution of methyl(triphenyl)phosphonium bromide (270 mg, 754 μmol) in THF (5 mL) was added KO^(t)Bu (85 mg, 754 μmol) at 0° C. and the mixture stirred at 0° C. to RT for 0.5 h. A solution of (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carbaldehyde (40-1; 50 mg, 151 μmol) in THF (2 mL) was added at 0° C. and the mixture stirred for 2 h. Water and EtOAc were added, the mixture washed with saturated ammonium chloride solution and dried over sodium sulfate. After filtration and concentration the residue was purified by preparative TLC (MeOH:DCM) to give the title compound (29 mg, 55%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.38 (2H), 2.79 (1H), 2.92-3.05 (2H), 5.07 (1H), 5.14 (1H), 5.95 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.47 (2H), 8.42 (2H), 11.96 (1H)

Example 41 1-Ethyl-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), isocyanatoethane (14 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (23 mg, 59%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.00 (3H), 2.16-2.35 (3H), 2.60 (1H), 2.93 (1H), 2.99-3.08 (3H), 3.13 (1H), 5.81 (1H), 6.04 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.92 (1H)

Example 42 1-Cyclopropyl-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), isocyanatocyclopropane (15 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (22 mg, 55%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.35 (2H), 0.58 (2H), 2.17-2.35 (3H), 2.41(1H), 2.60 (1H), 2.93 (1H), 3.04-3.19 (2H), 6.11 (1H), 6.17 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.93 (1H)

Example 43 1-[(6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-3-propan-2-ylurea

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-isocyanatopropane (18 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (17 mg, 42%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (3H), 1.04 (3H), 2.16-2.35 (3H), 2.59 (1H), 2.92 (1H), 3.02-3.18 (2H), 3.67 (1H), 5.68 (1H), 5.93 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.93 (1H)

Example 44 1-(Furan-2-ylmethyl)-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-(isocyanatomethyl)furan (19 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (20 mg, 46%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.17-2.35 (3H), 2.60 (1H), 2.93 (1H), 3.05-3.20 (2H), 4.21 (2H), 6.18 (1H), 6.20 (1H), 6.30 (1H), 6.38 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.57 (1H), 8.41 (2H), 11.94 (1H)

Example 45 1-(3-Chloro-4-fluoropheny0-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-chloro-1-fluoro-4-isocyanatobenzene (22 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (23 mg, 48%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.22-2.41 (3H), 2.66 (1H), 2.97 (1H), 3.13-3.32(2H), 6.55 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.24 (1H), 7.27 (1H), 7.44 (1H), 7.46 (2H), 7.79 (1H), 8.41 (2H), 8.81 (1H), 11.93 (1H)

Example 46 Methyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), methyl carbonochloridate (14 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 2 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (20 mg, 54%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.18-2.38 (3H), 2.62 (1H), 2.94 (1H), 3.10 (2H), 3.55 (3H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.34 (1H), 7.43 (1H), 7.46 (2H), 8.40 (2H), 11.94 (1H)

Example 47 N-[(6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylacetamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), acetyl chloride (13 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 2 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (8 mg, 23%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.85 (3H), 2.22 (1H), 2.28-2.37 (2H), 2.61 (1H), 2.93 (1H), 3.11 (1H), 3.19 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.47 (2H), 8.00 (1H), 8.40 (2H), 11.98 (1H)

Example 48 N-[(6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylmethanesulfonamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), methanesulfonyl chloride (14 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 2 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (13 mg, 3%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.26 (1H), 2.32-2.41 (2H), 2.67 (1H), 2.93 (3H), 2.99-3.08 (3H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.22 (1H), 7.44 (1H), 7.47 (2H), 8.41 (2H), 11.97 (1H)

Example 49 (6RS)-2-(3-Methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (15; 291 mg, 743 μmol), potassium hydroxide (2.97 mL, 4M in water), THF (6 mL) and MeOH (6 mL) was stirred at RT for 15 minutes. Hydrochloric acid (4 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (215 mg, 77%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.55 (1H), 3.06-3.22 (4H), 3.89 (3H), 6.52 (2H), 6.58 (1H), 6.98 (2H), 7.30 (1H), 7.42 (1H), 8.01 (1H), 8.34 (1H), 11.38 (1H), 12.61 (1H)

Example 50 Methyl (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (31; 177 mg, 470 μmol), acetyl chloride (67 μL, 940 μmol) in pyridine (5 mL) and THF (0.5 mL) was stirred at RT for 1 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (161 mg, 82%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.58 (2H), 3.11 (1H), 3.18 (1H), 3.34 (1H), 3.64 (3H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.37 (1H), 8.09 (1H), 8.23 (1H), 10.36 (1H), 12.01 (1H)

Example 51 (4E/Z)-5-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid

To a solution of (3-carboxypropyl)(triphenyl)phosphonium bromide (324 mg, 754 μmol) in THF (5 mL) was added KO^(t)Bu (169 mg, 1.51 mmol) at 0° C. and the mixture stirred at 0° C. to RT for 0.5 h. A solution of (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carbaldehyde (40-1; 50 mg, 151 μmol) in THF (2 mL) was added at 0° C. and the mixture stirred for 2 h. Water and EtOAc were added, the mixture washed with brine and dried over sodium sulfate. After filtration and concentration the residue was purified by preparative TLC (MeOH:DCM) to give the title compound (27 mg, 42%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.15-2.37 (6H), 2.71 (1H), 2.93 (1H), 3.26 (1H), 5.40 (2H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.49 (2H), 8.40 (2H), 12.17 (1H)

Example 52 (6RS)-2-(3-Fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (14; 222 mg, 585 μmol), potassium hydroxide (2.34 mL, 4M in water), THF (5 mL) and MeOH (5 mL) was stirred at RT for 15 minutes. Hydrochloric acid (3.1 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (185 mg, 85%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.42-2.62 (3H), 3.10 (2H), 6.55 (2H), 6.60 (1H), 6.99 (2H), 7.39 (1H), 7.56 (1H), 8.24 (1H), 8.50 (1H), 11.67 (1H)

Example 53 (6RS)-6-[(E/Z)-2-(4-Fluorophenyl)ethenyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

To a solution of (4-fluorobenzyl)(triphenyl)phosphonium bromide (340 mg, 754 μmol) in THF (5 mL) was added KO^(t)Bu (85 mg, 754 μmol) at 0° C. and the mixture stirred at 0° C. to RT for 0.5 h. A solution of (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carbaldehyde (40-1; 50 mg, 151 μmol) in THF (2 mL) was added at 0° C. and the mixture stirred for 2 h. Water and EtOAc were added, the mixture washed with brine and dried over sodium sulfate. After filtration and concentration the residue was purified by preparative TLC (MeOH:DCM) to give the title compound (34 mg, 50%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.30-2.53 (2H), 2.83-2.93 (1H), 2.96-3.48 (2H), 5.73+6.37 (1H), 6.47-6.65 (4H), 7.04 (2H), 7.14-7.22 (2H), 7.35 (1H), 7.43-7.50 (4H), 8.39-8.44 (2H), 11.99 (1H)

Example 54 (6RS)-6-(Morpholin-4-ylmethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 50 mg, 122 μmol), morpholine (53 μL, 608 μmol) in DMA (1.5 mL) was stirred at 100° C. for 2 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (15 mg, 30%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.20 (1H), 2.26-2.45 (7H), 2.47-2.56 (1H), 2.60 (1H), 3.05 (1H), 3.59 (4H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.91 (1H)

Example 55 (6RS)-6-[Methyl(propan-2-yl)amino]methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 50 mg, 122 μmol), N-methylpropan-2-amine (101 μL, 972 μmol) in DMA (1.5 mL) was stirred at 100° C. for 4 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (15 mg, 29%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.93 (6H), 2.15 (3H), 2.17 (1H), 2.27-2.41 (4H), 2.59 (1H), 2.75 (1H), 3.02 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.40 (2H), 11.89 (1H)

Example 56 (6RS)-6-[(1E/Z)-3-(Dimethylamino)prop-1-en-1-yl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

To a solution of [2-(dimethylamino)ethyl](triphenyl)phosphonium bromide (688 mg, 1.66 mmol) in THF (11 mL) was added KO^(t)Bu (186 mg, 1.66 mmol) at 0° C. and the mixture stirred at 0° C. to RT for 0.5 h. A solution of (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carbaldehyde (40-1; 110 mg, 332 μmol) in THF (5 mL) was added at 0° C. and the mixture stirred for 2 h. Water was added, the mixture extracted with EtOAc, washed with brine and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 28 g, MeOH:DCM) to give the title compound (49 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.13 (6H), 2.22 (1H), 2.37 (1H), 2.75 (1H), 2.85-2.95 (3H), 3.28 (1H), 5.47 (1H), 5.57 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.47 (2H), 8.41 (2H), 11.94 (1H)

Example 57 1-[(6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-3-(2RS)-(tetrahydrofuran-2-ylmethyl)urea

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), (2R⁵)-2-(isocyanatomethyl)tetrahydrofuran (21 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (28 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.48 (1H), 1.74-1.90 (3H), 2.16-2.33 (3H), 2.59 (1H), 2.92 (1H), 2.96-3.19 (4H), 3.61 (1H), 3.72-3.83 (2H), 5.91 (1H), 6.15 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.93 (1H)

Example 58 N-Methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 1

(6RS)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetra hydro-1H-indol-6-carboxamide (24; 20.5 mg, 51 μmol) were separated by preparative HPLC (chiral method) to give the title compound (8 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.81+0.86 (3H), 1.47+1.55 (2H), 2.24-2.36 (1H), 2.47-2.59 (2H), 2.83+3.04 (3H), 2.89-3.08 (2H), 3.19-3.36 (1H), 3.64 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.95 (1H)

Example 59 N,N-Dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 1

(6RS)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide (25; 110 mg, 294 μmol) were separated by preparative HPLC (chiral method) to give the title compound (41 mg, 37%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.46 (1H), 2.85 (3H), 2.95 (1H), 3.03 (1H), 3.07 (3H), 3.66 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.96 (1H)

Example 60 N,N-Dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 2

(6RS)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide (25; 110 mg, 294 μmol) were separated by preparative HPLC (chiral method) to give the title compound (42 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.46 (1H), 2.85 (3H), 2.95 (1H), 3.03 (1H), 3.07 (3H), 3.66 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.96 (1H)

Example 61 N-Methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 2

(6RS)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide (24; 20.5 mg, 51 μmol) were separated by preparative HPLC (chiral method) to give the title compound (9 mg, 44%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.81+0.86 (3H), 1.47+1.55 (2H), 2.24-2.36 (1H), 2.47-2.59 (2H), 2.83+3.04 (3H), 2.89-3.08 (2H), 3.19-3.36 (1H), 3.64 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.95 (1H)

Example 62 (6RS)-3-(Phenylamino)-6-[(propan-2-ylsulfany0methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 150 mg, 365 μmol), sodium propane-2-thiolate (179 mg, 1.82 mmol) in DMA (5 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (63 mg, 44%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.22 (6H), 2.30 (1H), 2.37 (1H), 2.46 (1H), 2.62-2.72 (3H), 2.95 (1H), 3.13 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.47 (2H), 8.41 (2H), 11.94 (1H)

Example 63 (6RS)-6-[(Ethylsulfany0methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 150 mg, 365 μmol), sodium ethanethiolate (153 mg, 1.82 mmol) in DMA (5 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (45 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.19 (3H), 2.29 (1H), 2.39 (1H), 2.45 (1H), 2.54 (2H), 2.60-2.72 (3H), 3.13 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.94 (1H)

Example 64 4-Fluoro-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylbenzenesulfonamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 4-fluorobenzenesulfonyl chloride (35 mg, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (26 mg, 56%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.20 (1H), 2.28-2.35 (2H), 2.64 (1H), 2.86 (2H), 2.99 (1H), 6.56 (2H), 6.63 (1H), 7.04 (2H), 7.42-7.49 (5H), 7.85-7.90 (3H), 8.41 (2H), 11.94 (1H)

Example 65 2-Methoxyethyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-methoxyethyl carbonochloridate (21 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (24 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.22 (1H), 2.27-2.37 (2H), 2.62 (1H), 2.94 (1H), 3.10 (2H), 3.26 (3H), 3.50 (2H), 4.08 (2H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.41-7.49 (4H), 8.41 (2H), 11.93 (1H)

Example 66 2-Fluoroethyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-fluoroethyl carbonochloridate (17 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (23 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.23 (1H), 2.28-2.39 (2H), 2.63 (1H), 2.95 (1H), 3.12 (2H), 4.16 (1H), 4.26 (1H), 4.54 (1H), 4.66 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 7.53 (1H), 8.41 (2H), 11.94 (1H)

Example 67 (6RS)-6-[(1,3-Benzothiazol-2-ylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (32-1; 150 mg, 365 μmol), sodium 1,3-benzothiazole-2-thiolate (345 mg, 1.82 mmol) in DMA (5 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (70 mg, 40%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.43 (1H), 2.53-2.55 (1H), 2.71 (1H), 2.83 (1H), 3.16 (1H), 3.59 (2H), 6.58 (2H), 6.62 (1H), 7.03 (2H), 7.37 (1H), 7.42-7.47 (4H), 7.83 (1H), 8.02 (1H), 8.40 (2H), 11.94 (1H)

Example 68 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (50; 158 mg, 378 μmol), potassium hydroxide (1.51 mL, 4M in water), THF (1.5 mL) and MeOH (1.5 mL) was stirred at RT for 15 minutes. Hydrochloric acid (2.0 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (106 mg, 66%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.51-2.61 (2H), 3.07-3.23 (3H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.37 (1H), 8.08 (1H), 8.22 (1H), 10.36 (1H), 11.98 (1H), 12.62 (1H)

Example 69 N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcyclopropanecarboxamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), cyclopropanecarbonyl chloride (16 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (27 mg, 71%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.62-0.73 (4H), 1.58 (1H), 2.24 (1H), 2.30-2.40 (2H), 2.61 (1H), 2.94 (1H), 3.14 (1H), 3.23 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.22 (1H), 8.41 (2H), 11.93 (1H)

Example 70 2-Methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-methylpropanoyl chloride (19 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (27mg, 70%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (6H), 2.23 (1H), 2.28-2.43 (3H), 2.60 (1H), 2.92 (1H), 3.09-3.22 (2H), 6.57 (2H), 6.63 (1H), 7.04(2H), 7.43 (1H), 7.46 (2H), 7.89 (1H), 8.41 (2H), 11.92 (1H)

Example 71 2-Methoxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylacetamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), methoxyacetyl chloride (17 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (30 mg, 77%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.22 (1H), 2.31 (1H), 2.41 (1H), 2.61 (1H), 2.92 (1H), 3.15-3.28 (2H), 3.34 (3H), 3.84 (2H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.02 (1H), 8.41 (2H), 11.92 (1H)

Example 72 N-[(6RS)-4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcyclobutanecarboxamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), cyclobutanecarbonyl chloride (21 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (26 mg, 67%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.77 (1H), 1.89 (1H), 1.99-2.07 (2H), 2.08-2.20 (2H), 2.24 (1H), 2.28-2.39 (2H), 2.59 (1H), 2.91 (1H), 3.03 (1H), 3.11 (1H), 3.19 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 7.81 (1H), 8.41 (2H), 11.92 (1H)

Example 73 N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropane-2-sulfonamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 50 mg, 150 μmol), propane-2-sulfonyl chloride (68 μL, 602 μmol) in pyridine (1.7 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (8 mg, 11%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.24 (6H), 2.22-2.44 (3H), 2.66 (1H), 2.99-3.10 (3H), 3.20 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.21 (1H), 7.44 (1H), 7.47 (2H), 8.41 (2H), 11.96 (1H)

Example 74 N-(2-Hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 1

(6RS)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide (17; 120 mg, 297 μmol) were separated by preparative HPLC (chiral method) to give the title compound (36 mg, 30%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.30-2.38 (1H), 2.46-2.57 (1H), 2.86+3.10 (3H), 2.92-3.07 (2H), 3.28-3.55 (4H), 3.64+3.72 (1H), 4.69+4.86 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.42-7.48 (3H), 8.41 (2H), 11.96 (1H)

Example 75 N-(2-Hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 2

(6RS)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide (17; 120 mg, 297 μmol) were separated by preparative HPLC (chiral method) to give the title compound (30 mg, 24%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.30-2.38 (1H), 2.46-2.57 (1H), 2.86+3.10 (3H), 2.92-3.07 (2H), 3.28-3.55 (4H), 3.64+3.72 (1H), 4.69+4.86 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.42-7.48 (3H), 8.41 (2H), 11.96 (1H)

Example 76 (6RS)-2-(3-Fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (52; 70 mg, 192 μmol), DMF (2 mL), DIPEA (100 μL, 575 μmol), N-methylmethanamine (287 μL, 2M in THF) and T3P (173 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (53 mg, 70%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.35 (1H), 2.52 (1H), 2.85 (3H), 2.94-3.03 (2H), 3.07 (3H), 3.67 (1H), 6.59 (2H), 6.60 (1H), 6.99 (2H), 7.40 (1H), 7.54 (1H), 8.24 (1H), 8.50 (1H), 11.68 (1H)

Example 77 (6RS)-2-(3-Methoxypyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (49; 70 mg, 185 μmol), DMF (2 mL), DIPEA (97 μL, 556 μmol), N-methylmethanamine (287 μL, 2M in THF) and T3P (167 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (47 mg, 63%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.32 (1H), 2.52 (1H), 2.85 (3H), 2.96-3.01 (2H), 3.07 (3H), 3.65 (1H), 3.89 (3H), 6.54 (2H), 6.58 (1H), 6.98 (2H), 7.30 (1H), 7.41 (1H), 8.01 (1H), 8.34 (1H), 11.34 (1H)

Example 78 (6RS)-2-(3-Fluoropyridin-4-yl)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (52; 70 mg, 192 μmol), DMF (2 mL), DIPEA (100 μL, 575μmol) , 2-(methylamino)ethanol (46 μL, 575μmol) and T3P (173 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (41 mg, 48%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.35 (1H), 2.54 (1H), 2.86+3.11 (3H), 2.95-3.03 (2H), 3.29-3.55 (4H), 3.64+3.72 (1H), 4.68+4.86 (1H), 6.57 (2H), 6.60 (1H), 6.99 (2H), 7.40 (1H), 7.54 (1H), 8.25 (1H), 8.50 (1H), 11.68 (1H)

Example 79 (6RS)-N-(2-Hydroxyethyl)-2-(3-methoxypyridin-4-yl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (49; 70 mg, 185 μmol), DMF (2 mL), DIPEA (97 μL, 556 μmol), 2-(methylamino)ethanol (45 μL, 556 μmol) and T3P (167 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (54 mg, 67%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.29-2.36 (1H), 2.54 (1H), 2.86+3.11 (3H), 2.95-3.03 (2H), 3.36-3.55 (4H), 3.62+3.71 (1H), 3.88+3.89 (3H), 4.68+4.85 (1H), 6.54 (2H), 6.58 (1H), 6.98 (2H), 7.30 (1H), 7.40+7.41 (1H), 8.01 (1H), 8.34 (1H), 11.34 (1H)

Example 80 (6RS)-3-(Phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising (6RS)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (62; 130 mg, 332 μmol), mCPBA (70 mg, 75%) and DMA (10 mL) was stirred at RT. After 4 h a second portion mCPBA (35 mg, 75%) was added and after 4 h a third portion mCPBA (35 mg, 75%). The mixture was stirred at RT for 16 h, Et₃N (200 μL) was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (93 mg, 63%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.27 (6H), 2.42 (1H), 2.53-2.59 (2H), 2.79-2.95 (2H), 3.24-3.32 (3H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.48 (2H), 8.42 (2H), 12.01 (1H)

Example 81 (6RS)-6-[(Ethylsulfonyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising (6RS)-6-[(ethylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (63; 128 mg, 339 μmol), mCPBA (72 mg, 75%) and DMA (10 mL) was stirred at RT. After 4 h a second portion mCPBA (36 mg, 75%) was added and after 4 h a third portion mCPBA (36 mg, 75%). The mixture was stirred at RT for 16 h, Et₃N (200 μL) was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (82 mg, 56%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.24 (3H), 2.40 (1H), 2.53 (1H), 2.79-2.91 (2H), 3.16 (2H), 3.24-3.35 (3H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 8.41 (2H), 12.01 (1H)

Example 82 3-Methoxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 3-methoxypropanoyl chloride (22 mg, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. MeOH was added, the mixture concentrated and purified by crystallization from MeOH to give the title compound (13 mg, 34%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.27-2.42 (5H), 2.68 (1H), 3.00 (1H), 3.13-3.25 (2H), 3.22 (3H), 3.54 (2H), 6.70 (2H), 6.76 (1H), 7.12 (2H), 7.79 (2H), 8.03-8.10 (2H), 8.59 (2H), 12.63 (1H)

Example 83 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (68; 50 mg, 123 μmol), DMF (2 mL), DIPEA (65 μL, 371 μmol), N-methylmethanamine (185 μL, 2M in THF) and T3P (111 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (28 mg, 52%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.31 (1H), 2.49 (1H), 2.85 (3H), 2.94-3.01 (2H), 3.06 (3H), 3.64 (1H), 6.57 (2H), 6.61 (1H), 7.02 (2H), 7.15 (1H), 7.36 (1H), 8.08 (1H), 8.23 (1H), 10.35 (1H), 11.95 (1H)

Example 84 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (68; 50 mg, 123 μmol), DMF (2 mL), DIPEA (65 μL, 371 μmol), 2-(methylamino)ethanol (30 μL, 371 μmol) and T3P (111 μL, 50% in DMF) was stirred at RT for 16 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (33 mg, 55%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.28-2.36 (1H), 2.53-2.59 (1H), 2.85+3.10 (3H), 2.93-3.03 (2H), 3.29-3.54 (4H), 3.62+3.69 (1H), 4.69+4.85 (1H), 6.57 (2H), 6.61 (1H), 7.02 (2H), 7.15 (1H), 7.35+7.36 (1H), 8.08 (1H), 8.23 (1H), 10.35 (1H), 11.96 (1H)

Example 85 Methyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate Isomer 1

Methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (8; 213 mg, 589 μmol) were separated by preparative HPLC (chiral method) to give the title compound (80 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.56-2.62 (2H), 3.09-3.21 (2H), 3.37 (1H), 3.64 (3H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44-7.49 (3H), 8.42 (2H), 12.00 (1H)

Example 86 Methyl 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate Isomer 2

Methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (8; 213 mg, 589 μmol) were separated by preparative HPLC (chiral method) to give the title compound (85 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.56-2.62 (2H), 3.09-3.21 (2H), 3.37 (1H), 3.64 (3H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44-7.49 (3H), 8.42 (2H), 12.00 (1H)

Example 87 (6RS)-2-(2-Aminopyridin-4-yl)-6-(hydroxymethyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one 87-2: (4RS)-2-{[(2-Aminopyridin-4-yl)methyl]amino}-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide

A solution of (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide (1-3; 33.9 g, 65.7 mmol) and 4-(aminomethyl)pyridin-2-amine (16.2 g, 131 mmol) in DMA (250 mL) was heated at 120° C. for 2 h. The mixture was concentrated and purified by Biotage (SNAP silica 750 g, EtOH:DCM) to give the title compound (24.8 g, 60%).

87-1: (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (4RS)-2-{[(2-Aminopyridin-4-yl)methyl]amino}-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide (87-2; 16.3 g, 26.3 mmol), hydrogen peroxide (30% in water, 10.7 mL, 105 mmol) in MeOH (500 mL) was heated at 50° C. for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 375 g, MeOH:DCM) to give the title compound (8.95 g, 58%).

(6RS)-2-(2-Aminopyridin-4-yl)-6-(hydroxymethyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,5,6,7-tetrahydro-4H-indol-4-one (87-1; 3.0 g, 5.11 mmol) and TBAF (6.1 mL, 1M in THF) in THF (80 mL) was stirred at 50° C. for 2 h. EtOAc (1 L) was added, the mixture washed with sodium hydroxide (2.5% in water), brine and dried over sodium sulfate. After filtration and removal of the solvent the residue was purified by Biotage (SNAP silica 110 g, MeOH:DCM) to give the title compound (1.17 g, 62%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.16-2.34 (3H), 2.62 (1H), 2.93 (1H), 3.43 (2H), 4.74 (1H), 5.73 (2H), 6.53-6.62 (4H), 6.69 (1H), 7.02 (2H), 7.23 (1H), 7.75 (1H), 11.69 (1H)

Example 88 4-Fluoro-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylbenzamide

A solution of 4-fluorobenzoic acid (34 mg, 241 μmol) and HATU (92 mg, 241 μmol) in DMA (1 mL) was added to a mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 40 mg, 120 μmol) and DIPEA (42 μL, 241 μmol) in DMA (1 mL) and the reaction was stirred at 50C for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (33 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.28-2.41 (2H), 2.53-2.58 (1H), 2.69 (1H), 2.99 (1H), 3.31-3.46 (2H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.32 (2H), 7.44 (1H), 7.46 (2H), 7.96 (2H), 8.40 (2H), 8.66 (1H), 11.92 (1H)

Example 89 tert-Butyl [(2S)-1-oxo-1-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylamino)propan-2-yl]carbamate

A solution of N-(tert-butoxycarbonyl)-L-alanine (129 mg, 680 μmol) and HATU (258 mg, 680 μmol) in DMA (3 mL) was added to a mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 113 mg, 340 μmol) and DIPEA (118 μL, 680 μmol) in DMA (3 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 28 g, MeOH:DCM) to give the title compound (56 mg, 33%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.20 (3H), 1.36 (9H), 2.19-2.40 (3H), 2.61 (1H), 2.90 (1H), 3.09-3.29 (2H), 3.94 (1H), 6.57 (2H), 6.63 (1H), 6.92 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 7.93 (1H), 8.41 (2H), 11.93 (1H)

Example 90 tert-Butyl (2S)-2-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamoyl)pyrrolidine-1-carboxylate

A solution of 1-(tert-butoxycarbonyl)-L-proline (97 mg, 451 μmol) and HATU (172 mg, 451 μmol) in DMA (2 mL) was added to a mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 75 mg, 226 μmol) and DIPEA (79 μL, 451 μmol) in DMA (2 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 28 g, MeOH:DCM) to give the title compound (85 mg, 71%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.31+1.38 (9H), 1.73-1.88 (3H), 2.12 (1H), 2.24 (1H), 2.25-2.42 (2H), 2.63 (1H), 2.92 (1H), 3.13 (1H), 3.20-3.31 (2H), 3.40 (1H), 4.06 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.42 (1H), 7.47 (2H), 7.96+8.05 (1H), 8.41 (2H), 11.91 (1H)

Example 91 (2S)-2-Hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide

A solution of (2S)-2-hydroxypropanoic acid (22 mg, 241 μmol) and HATU (92 mg, 241 μmol) in DMA (1 mL) was added to a mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 40 mg, 120 μmol) and DIPEA (42 μL, 241 μmol) in DMA (1 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified preparative HPLC (basic method) to give the title compound (29 mg, 56%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.24 (3H), 2.22 (1H), 2.30 (1H), 2.40 (1H), 2.61 (1H), 2.91 (1H), 3.13-3.27 (2H), 4.00 (1H), 5.51 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 7.91 (1H), 8.40 (2H), 11.93 (1H)

Example 92 N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-1,3-thiazole-2-carboxamide

A solution of 1,3-thiazole-2-carboxylic acid (31 mg, 241 μmol) and HATU (92 mg, 241 μmol) in DMA (1 mL) was added to a mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 40 mg, 120 μmol) and DIPEA (42 μL, 241 μmol) in DMA (1 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified preparative HPLC (basic method) to give the title compound (22 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.26-2.38 (2H), 2.55 (1H), 2.68 (1H), 2.97 (1H), 3.31-3.47 (2H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.42-7.47 (3H), 8.04 (1H), 8.07 (1H), 8.40 (2H), 9.09 (1H), 11.91 (1H)

Example 93 1-Methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-1H-pyrrole-2-carboxamide

A solution of 1-methyl-1H-pyrrole-2-carboxylic acid (30 mg, 241 μmol) and HATU (92 mg, 241 μmol) in DMA (1 mL) was added to a mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 40 mg, 120 μmol) and DIPEA (42 μL, 241 μmol) in DMA (1 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified preparative HPLC (basic method) to give the title compound (6 mg, 11%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.24-2.39 (2H), 2.42-2.54 (1H), 2.66 (1H), 2.98 (1H), 3.22-3.36 (2H), 3.84 (3H), 6.02 (1H), 6.57 (2H), 6.63 (1H), 6.81 (1H), 6.90 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.12 (1H), 8.40 (2H), 11.92 (1H)

Example 94 N-4-[(6RS)-6-(Hydroxymethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide 94-1: N-{4-[(6RS)-3-Anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,5,6,7-tetrahydro-4H-indol-4-one (87-1; 2.34 g, 3.99 mmol), acetyl chloride (425 μL, 5.98 mmol) in THF (100 mL) and pyridine (2.78 mL) was stirred at RT for 1 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (2.46 g, 98%).

N-4-[(6RS)-6-(Hydroxymethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of N-{4-[(6RS)-3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide (94-1; 2.45 g, 3.90 mmol) and TBAF (4.68 mL, 1M in THF) in THF (65 mL) was stirred at RT for 16 h. EtOAc was added, the mixture washed with sodium hydroxide (2.5% in water), brine and dried over sodium sulfate. After filtration and removal of the solvent the residue was purified by crystallization from MeOH/DCM and Biotage (SNAP silica 25 g, MeOH:DCM) of the mother liquor to give the title compound (1.17 g, 77%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.19-2.35 (3H), 2.65 (1H), 2.96 (1H), 3.39-3.48 (2H), 4.75 (1H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.36 (1H), 8.08 (1H), 8.22 (1H), 10.34 (1H), 11.91 (1H)

Example 95 N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyltetrahydro-2H-pyran-4-carboxamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), tetrahydro-2H-pyran-4-carbonyl chloride (27 mg, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (19 mg, 45%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.57-1.65 (4H), 2.20-2.43 (4H), 2.60 (1H), 2.92 (1H), 3.16 (2H), 3.26-3.35 (2H), 3.87 (2H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.47 (2H), 7.95 (1H), 8.40 (2H), 11.98 (1H)

Example 96 N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylfuran-2-carboxamide

A mixture of (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (36; 30 mg, 90 μmol), 2-furoyl chloride (18 μL, 181 μmol) in pyridine (1 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (16 mg, 40%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.28 (1H), 2.36 (1H), 2.45-2.54 (1H), 2.66 (1H), 2.97 (1H), 3.26-3.42 (2H), 6.57 (2H), 6.63 (1H), 6.64 (1H), 7.04 (2H), 7.13 (1H), 7.44 (1H), 7.45 (2H), 7.86 (1H), 8.40 (2H), 8.55 (1H), 11.91 (1H)

Example 97 (6RS)-N-(2-Hydroxy-2-methylpropyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (1.5 mL), DIPEA (89 μL, 518 μmol), 2-methyl-1-(methylamino)propan-2-ol (61 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (49 mg, 66%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.04+1.11 (6H), 2.28+2.38 (1H), 2.47-2.57 (1H), 2.88-3.08 (2H), 2.94+3.18 (3H), 3.23-3.39 (2H), 3.68+3.83 (1H), 4.51+4.60 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.92+11.95 (1H)

Example 98 (6RS)-N-[(2S)-2-Hydroxypropyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (0.95 mL), DIPEA (89 μL, 518 μmol), (2S)-1-aminopropan-2-ol (41 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (42 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.02 (3H), 2.39 (1H), 2.55 (1H), 2.95-3.18 (5H), 3.65 (1H), 4.69 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.99 (1H), 8.42 (2H), 11.96 (1H)

Example 99 (6RS)-N-(1-Hydroxy-2-methylpropan-2-yl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2-amino-2-methylpropan-1-ol (49 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (26 mg, 36%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.19 (6H), 2.36 (1H), 2.47-2.55 (1H), 2.91-3.15 (3H), 3.41 (2H), 4.81 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.42-7.49 (4H), 8.41 (2H), 11.95 (1H)

Example 100 (6RS)-N-(2,2-Dimethylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2,2-dimethylpropan-1-amine (61 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (48 mg, 60%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.84 (9H), 2.37 (1H), 2.57 (1H), 2.89-3.09 (4H), 3.17 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.90 (1H), 8.41 (2H), 11.97 (1H)

Example 101 (6RS)-N-(2-Methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2-methylpropan-1-amine (51 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (48 mg, 69%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.85 (6H), 1.69 (1H), 2.38 (1H), 2.56 (1H), 2.86-3.05 (4H), 3.10 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 7.99 (1H), 8.41 (2H), 11.98 (1H)

Example 102 (6RS)-N-Methyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), N,2-dimethylpropan-1-amine (62 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (32 mg, 44%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.80-0.89 (6H), 1.90 (1H), 2.25+2.35 (1H), 2.46-2.58 (1H), 2.83+3.05 (3H), 2.92-3.25 (4H), 3.66 (1H), 6.58-6.66 (3H), 7.05 (2H), 7.43-7.47 (3H), 8.41 (2H), 11.95 (1H)

Example 103 (6RS)-N-[2-(Dimethylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), N,N-dimethylethane-1,2-diamine (57 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (27 mg, 36%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.15 (6H), 2.29 (2H), 2.37 (1H), 2.54 (1H), 2.94-3.21 (5H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.95 (1H), 8.41 (2H), 11.95 (1H)

Example 104 (6RS)-N-[2-(Dimethylamino)ethyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), N,N,N′-trimethylethane-1,2-diamine (67 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (33 mg, 42%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.15+2.17 (6H), 2.28-2.42 (3H), 2.46-2.55 (1H), 2.86+3.07 (3H), 2.92-3.05 (2H), 3.36-3.51 (2H), 3.63 (1H), 6.59 (2H), 6.64 (1H), 7.04 (2H), 7.43-7.47 (3H), 8.41 (2H), 11.95 (1H)

Example 105 (6RS)-N-Methyl-N-[2-(methylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), N,N′-dimethylethane-1,2-diamine (56 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (15 mg, 19%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.27+2.28 (3H), 2.29-2.37 (1H), 2.48-2.55 (1H), 2.60 (2H), 2.85+3.07 (3H), 2.92-3.03 (2H), 3.32-3.45 (2H), 3.64 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.96 (1H)

Example 106 (6RS)-N-(2,2-Difluoroethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2,2-difluoroethanamine (37 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (36 mg, 46%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.41 (1H), 2.56 (1H), 3.03 (2H), 3.17 (1H), 3.52 (2H), 6.03 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 8.42 (2H), 8.44 (1H), 11.97 (1H)

Example 107 (6RS)-N-Methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2,2,2-trifluoro-N-methylethanamine (59 mg, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (21 mg, 26%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.26+2.36 (1H), 2.47-2.56 (1H), 2.88-3.07 (2H), 2.98+3.20 (3H), 3.76 (1H), 4.21+4.49 (2H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.42 (2H), 11.97 (1H)

Example 108 (6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 3,3,3-trifluoropropan-1-amine (51 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (38 mg, 47%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.35-2.58 (5H), 2.96-3.12 (3H), 3.31 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.26 (1H), 8.41 (2H), 11.97 (1H)

Example 109 (6RS)-N-(2,2-Difluoroethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2,2-difluoro-N-methylethanamine (61 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (31 mg, 42%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.29+2.36 (1H), 2.44-2.57 (1H), 2.89-3.07 (2H), 2.93+3.16 (3H), 3.64-3.81+3.96 (3H), 6.12 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43 (1H), 7.46 (2H), 8.42 (2H), 11.97 (1H)

Example 110 (6RS)-N-tert-Butyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), N,2-dimethylpropan-2-amine (62 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 day. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (16 mg, 20%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.35 (9H), 2.32 (1H), 2.48 (1H), 2.89-3.05 (2H), 2.95 (3H), 3.64 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.45 (2H), 8.41 (2H), 11.92 (1H)

Example 111 (6RS)-N-[(1-Hydroxycyclopropyl)methyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 1-(aminomethyl)cyclopropanol (38 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 day. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (25 mg, 31%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.48 (2H), 0.52 (2H), 2.38 (1H), 2.54 (1H), 2.94-3.09 (2H), 3.14 (1H), 3.24 (2H), 5.34 (1H), 6.57 (2H), 6.62 (1H), 7.03 (2H), 7.44 (1H), 7.45 (2H), 8.03 (1H), 8.41 (2H), 11.95 (1H)

Example 112 (6RS)-N-(2-Hydroxy-2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2,2-dimethylpropan-1-amine (61 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (41 mg, 72%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.05 (3H), 1.06 (3H), 2.38 (1H), 2.56 (1H), 2.96-3.11 (4H), 3.20 (1H), 4.47 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.90 (1H), 8.41 (2H), 11.96 (1H)

Example 113 (6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2,2-dimethylpropan-1-amine (61 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (30 mg, 36%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.41 (1H), 2.56 (1H), 3.04 (2H), 3.20 (1H), 3.94 (2H), 6.57 (2H), 6.62 (1H), 7.03 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 8.70 (1H), 11.97 (1H)

Example 114 (6RS)-N-Methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 3,3,3-trifluoro-N-methylpropan-1-amine hydrochloride (85 mg, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (48 mg, 79%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.31 (1H), 2.41-2.56 (3H), 2.85+3.08 (3H), 2.91-3.04 (2H), 3.46-3.68 (3H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.96 (1H)

Example 115 (6RS)-N-[(2R)-2-Hydroxypropyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2(2R)-1-aminopropan-2-ol (41 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (42 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.02 (3H), 2.39 (1H), 2.55 (1H), 2.95-3.08 (4H), 3.14 (1H), 3.65 (1H), 4.71 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 7.99 (1H), 8.42 (2H), 11.96 (1H)

Example 116 4-Oxo-3-(phenylamino)-2-(pyridin-4-y0-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid Isomer 1

4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol) were separated by preparative HPLC (chiral method) to give the title compound (15 mg, 29%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.60 (2H), 3.17 (2H), 3.27 (1H), 6.63 (2H), 6.69 (1H), 7.08 (2H), 7.63 (2H), 7.77 (1H), 8.50 (2H), 12.39 (1H), 12.65 (1H)

Example 117 4-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid Isomer 2

4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol) were separated by preparative HPLC (chiral method) to give the title compound (15 mg, 29%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.60 (2H), 3.17 (2H), 3.27 (1H), 6.63 (2H), 6.69 (1H), 7.08 (2H), 7.63 (2H), 7.77 (1H), 8.50 (2H), 12.39 (1H), 12.65 (1H)

Example 118 (6RS)-6-[(4-Methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (1.5 mL), DIPEA (75 μL, 432 μmol), 1-methylpiperazine (48 μL, 432 μmol) and T3P (130 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (40 mg, 65%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.19 (3H), 2.22-2.36 (5H), 2.53 (1H), 2.93-3.07 (2H), 3.41-3.58 (4H), 3.67 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.95 (1H)

Example 119 (6RS)-6-[(3S)-3-Hydroxypyrrolidin-1-yl]carbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), (3S)-pyrrolidin-3-ol (42 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (44 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.71-1.99 (2H), 2.32-2.39 (1H), 2.44-2.55 (2H), 2.92-3.09 (2H), 3.24-3.69 (4H), 4.26+4.32 (1H), 4.94+5.03 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.97 (1H)

Example 120 (6RS)-6-[(3R)-3-Hydroxypyrrolidin-1-yl]carbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), (3R)-pyrrolidin-3-ol (42 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (38 mg, 48%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.72-1.99 (2H), 2.32-2.39 (1H), 2.42-2.55 (2H), 2.92-3.09 (2H), 3.26-3.68 (4H), 4.26+4.32 (1H), 4.95+5.03 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.97 (1H)

Example 121 (6RS)-64(3-Hydroxyazetidin-1-yl)carbonyl1-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (1.5 mL), DIPEA (150 μL, 863 μmol), azetidin-3-ol hydrochloride (47 mg, 432μmol) and T3P (130 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (54 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.31 (1H), 2.45 (1H), 2.89-3.02 (2H), 3.23 (1H), 3.60 (1H), 3.93 (1H), 4.06 (1H), 4.39 (1H), 4.46 (1H), 5.75 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.42 (2H), 11.97 (1H)

Example 122 (6RS)-N,N-Diethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 50 mg, 144 μmol), DMF (1.5 mL), DIPEA (75 μL, 432 μmol), N-ethylethanamine (46 μL, 432 μmol) and T3P (130 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (37 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (3H), 1.13 (3H), 2.27 (1H), 2.56 (1H), 2.92 (1H), 3.05 (1H), 3.24 (1H), 3.30-3.42 (3H), 3.55 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.95 (1H)

Example 123

N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]acetamide

A mixture of 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), acetyl chloride (15 μL, 204 μmol) in pyridine (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (11 mg, 27%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.82 (3H), 2.43 (1H), 2.53 (1H), 2.84 (1H), 3.16 (1H), 4.30 (1H), 6.58-6.60 (2H), 6.64 (1H), 7.05 (2H), 7.47 (1H), 7.48 (2H), 8.25 (1H), 8.43 (2H), 12.00 (1H)

Example 124 2-Methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]propanamide

A mixture of 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), 2-methylpropanoyl chloride (21 μL, 204 μmol) in pyridine (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (9 mg, 23%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.99 (3H), 1.00 (3H), 2.37 (1H), 2.44-2.53 (2H), 2.84 (1H), 3.15 (1H), 4.29 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.46 (1H), 7.47 (2H), 8.11 (1H), 8.42 (2H), 11.96 (1H)

Example 125 3-Methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide

A mixture of 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), 3-methylbutanoyl chloride (25 μL, 204 μmol) in pyridine (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (15 mg, 35%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.87 (6H), 1.91-2.00 (3H), 2.46 (1H), 2.53 (1H), 2.86 (1H), 3.16 (1H), 4.32 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 8.18 (1H), 8.42 (2H), 11.97 (1H)

Example 126 3-Hydroxy-3-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide

A mixture comprising 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), DMF (1.5 mL), DIPEA (107 μL, 613 μmol), 3-hydroxy-3-methylbutanoic acid (33 μL, 307μmol) and T3P (184 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (9 mg, 20%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.14 (6H), 2.21 (2H), 2.45 (1H), 2.53 (1H), 2.88 (1H), 3.17 (1H), 4.36 (1H), 4.73 (1H), 6.60 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.46 (2H), 8.21 (1H), 8.42 (2H), 11.97 (1H)

Example 127 2-Cyclopropyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]acetamide

A mixture comprising 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), DMF (1.5 mL), DIPEA (107 μL, 613 μmol), cyclopropylacetic acid (29 μL, 307μmol) and T3P (184 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (17 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.11 (2H), 0.42 (2H), 0.95 (1H), 1.99 (2H), 2.44 (2H), 2.86 (1H), 3.16 (1H), 4.32 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.44 (1H), 7.47 (2H), 8.10 (1H), 8.42 (2H), 11.96 (1H)

Example 128 (3S)-3-Hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide

A mixture comprising 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), DMF (1.5 mL), DIPEA (107 μL, 613 μmol), (3S)-3-hydroxybutanoic acid (32 mg, 307μmol) and T3P (184 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (18 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.25 (1H), 1.06 (3H), 2.11 (1H), 2.22 (1H), 2.44 (1H), 2.85 (1H), 3.15 (1H), 3.60 (1H), 3.98 (1H), 4.32 (1H), 6.59 (2H), 6.63 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.19 (1H), 8.42 (2H), 11.96 (1H)

Example 129 3-Hydroxy-2,2-dimethyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]propanamide

A mixture comprising 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), DMF (1.5 mL), DIPEA (107 μL, 613 μmol), 3-hydroxy-2,2-dimethylpropanoic acid (36 mg, 307μmol) and T3P (184 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (11 mg, 24%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.04 (6H), 2.41 (1H), 2.54 (1H), 2.90 (1H), 3.09 (1H), 3.37 (2H), 4.34 (1H), 4.90 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.44 (1H), 7.47 (2H), 7.65 (1H), 8.42 (2H), 11.95 (1H)

Example 130 N-[(2S)-1-Hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 1

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), (2S)-2-aminopropan-1-ol (40 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (28 mg, 36%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.04 (3H), 2.38 (1H), 2.53 (1H), 2.93-3.12 (3H), 3.23 (1H), 3.32-3.37 (1H), 3.78 (1H), 4.71 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 7.80 (1H), 8.41 (2H), 11.96 (1H)

Example 131 N-[(2S)-1-Hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 2

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), (2S)-2-aminopropan-1-ol (40 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (29 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (3H), 2.37 (1H), 2.54 (1H), 2.94-3.12 (3H), 3.25 (1H), 3.37 (1H), 3.77 (1H), 4.71 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 7.79 (1H), 8.41 (2H), 11.95 (1H)

Example 132 N-[(2R)-1-Hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyriclin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 1

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), (2R)-2-aminopropan-1-ol (40 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (26 mg, 35%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.04 (3H), 2.38 (1H), 2.53 (1H), 2.93-3.12 (3H), 3.23 (1H), 3.34 (1H), 3.78 (1H), 4.71 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 7.80 (1H), 8.41 (2H), 11.95 (1H)

Example 133 (3R)-3-Hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-y0-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide

A mixture comprising 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), DMF (1.5 mL), DIPEA (107 μL, 613 μmol), (3R)-3-hydroxybutanoic acid (32 mg, 307μmol) and T3P (184 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (14 mg, 30%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.06 (3H), 2.11 (1H), 2.22 (1H), 2.40-2.55 (2H), 2.85 (1H), 3.15 (1H), 3.97 (1H), 4.32 (1H), 4.64 (1H), 6.59 (2H), 6.63 (1H), 7.05 (2H), 7.44 (1H), 7.46 (2H), 8.19 (1H), 8.42 (2H), 11.96 (1H)

Example 134 N-[(2R)-1-Hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide Isomer 2

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), (2R)-2-aminopropan-1-ol (40 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (27 mg, 37%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (3H), 2.37 (1H), 2.53 (1H), 2.93-3.12 (3H), 3.24 (1H), 3.36 (1H), 3.77 (1H), 4.71 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 7.79 (1H), 8.41 (2H), 11.96 (1H)

Example 135 (6RS)-N-[2-(Methylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), N-methylethane-1,2-diamine (45 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 day. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (19 mg, 25%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.35 (3H), 2.42 (1H), 2.55 (1H), 2.65 (2H), 2.99-3.13 (3H), 3.21 (2H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.47 (2H), 8.13 (1H), 8.32 (1H), 8.42 (2H), 12.02 (1H)

Example 136 N-[(6RS)-Oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-L-prolinamide

A mixture comprising tert-butyl (2S)-2-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamoyl)pyrrolidine-1-carboxylate (90; 82 mg, 155 μmol), TFA (179 μL, 2.32 mmol) and DCM (5 mL) was stirred at RT for 16 h. The mixture was poured into ammonia (25% in water), extracted with DM/MeOH, the organic layer was washed with water and dried over sodium sulfate. After filtration and concentration, the residue was purified by preparative HPLC (basic method) to give the title compound (49 mg, 70%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.61 (2H), 1.86 (1H), 1.96 (1H), 2.17-2.31 (2H), 2.38 (1H), 2.60 (1H), 2.78-2.93 (3H), 3.11-3.27 (2H), 3.53 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.46 (2H), 8.11 (1H), 8.41 (2H), 11.92 (1H)

Example 137 tert-Butyl methyl(3-oxo-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]aminopropyl)carbamate

A mixture comprising 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), DMF (1.5 mL), DIPEA (107 μL, 613 μmol), N-(tert-butoxycarbonyl)-N-methyl-beta-alanine (62 mg, 307 μmol) and T3P (184 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (21 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.39 (9H), 2.29 (2H), 2.43 (1H), 2.53 (1H), 2.76 (3H), 2.85 (1H), 3.16 (1H), 3.36 (2H), 4.31 (1H), 6.60 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 8.33 (1H), 8.42 (2H), 11.96 (1H)

Example 138 Methyl (6RS)-2-[2-[rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A solution of rel-(1R,2R)-2-fluorocyclopropanecarboxylic acid (318 mg, 3.06 mmol) and HATU (1.16 g, 3.06 mmol) in DMF (1 mL) was added to a mixture of methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (31; 500 mg, 1.33 mmol) and DIPEA (532 μL, 3.06 mmol) in DMF (1 mL) and the reaction was stirred at 50° C. for 16 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (812 mg, max. 100%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.26 (2H), 1.64 (1H), 2.20 (1H), 2.52 (1H), 2.58 (1H), 3.08-3.21 (2H), 3.64 (3H), 4.94 (1H), 6.55 (2H), 6.60 (1H), 7.02 (2H), 7.16 (1H), 7.39 (1H), 8.09 (1H), 8.26 (1H), 10.74 (1H), 12.04 (1H)

Example 139 (6RS)-6-[(1,3-Benzothiazol-2-ylsulfonyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising (6RS)-6-[(1,3-benzothiazol-2-ylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one (67; 115 mg, 238 μmol), mCPBA (50 mg, 75%) and DMA (7 mL) was stirred at RT. After 4 h a second portion mCPBA (25 mg, 75%) was added and after 4 h a third portion mCPBA (25 mg, 75%). The mixture was stirred at RT for 4 h, Et₃N (400 μL) was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (5 mg, 4%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.42-2.56 (2H), 2.85-2.98 (2H), 3.29 (1H), 3.96 (1H), 4.05 (1H), 6.57 (2H), 6.62 (1H), 7.04 (2H), 7.42 (1H), 7.46 (2H), 7.69-7.76 (2H), 8.27 (1H), 8.37 (1H), 8.41 (2H), 12.01 (1H)

Example 140 (6RS)-2-[2-([rel-(1R,2R)-2-Fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl methyl (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (138; 614 mg, 1.33 mmol), potassium hydroxide (5.3 mL, 4M in water), THF (5.4 mL) and MeOH (5.4 mL) was stirred at RT for 10 minutes. Hydrochloric acid (6 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (452 mg, 76%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.64 (1H), 2.20 (1H), 2.48-2.59 (2H), 3.06-3.25 (3H), 4.94 (1H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.39 (1H), 8.09 (1H), 8.26 (1H), 10.73 (1H), 12.02 (1H), 12.60 (1H)

Example 141 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid 141-4: methyl (1RS)-3-hydroxy-1-methyl-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

To a solution of methyl (1RS)-3-hydroxy-1-methyl-5-oxocyclohex-3-ene-1-carboxylate (6.98 g, 37.9 mmol; can be prepared according to Australian Journal of Chemistry, 1989 , 42(8), 1217-1225) and phenylisothiocyanate (5.44 mL, 45.5 mmol) in MeCN (75 mL) at 3° C. was added DBU (6.79 mL, 45.5 mmol) and the mixture was stirred at 3° C. for 16 h. The mixture was poured into water (1L), hydrochloric acid (10 mL, 4M) was added, the mixture was extracted with ethyl acetate, the organic layer was washed with water and brine and dried over sodium sulfate. After filtration the mixture was concentrated and dried to give the title compound (8.55 g, 71%).

141-3: Methyl (1RS)-3-{[(2-aminopyridin-4-yl)methyl]amino}-1-methyl-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-3-hydroxy-1-methyl-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (141-3; 8.55 g, 26.8 mmol) and 4-(methylamino)pyridine (5.94 g, 48.2 mmol) in DMA (75 mL) was heated at 100° C. for 1 h. The mixture was poured into water (1L), extracted with DCM, the organic layer was washed with water and brine and dried over sodium sulfate. After filtration the mixture was concentrated and purified by Biotage (SNAP silica 340 g, MeOH:DCM) to give the title compound (8.67 g, 76%).

141-2: Methyl (6RS)-2-(2-aminopyridin-4-yl)-3-anilino-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-{[(2-aminopyridin-4-yl)methyl]amino}-1-methyl-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (141-3; 6.07 g, 14.3 mmol), hydrogen peroxide (30% in water, 5.84 mL, 57.2 mmol) in MeOH (272 mL) was heated at 50° C. for 3 h. The mixture was concentrated and purified by Biotage (SNAP silica 110 g, MeOH:DCM) to give the title compound (3.19 g, 57%).

141-1: Methyl (6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

To a solution of methyl (6RS)-2-(2-aminopyridin-4-yl)-3-anilino-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (141-2; 1.60 g, 4.1 mmol) in THF (54 mL) and pyridine (2.86 mL) was added the solution of acetyl chloride (437 μL, 6.15 mmol) in THF (10 mL) over 20 minutes and the mixture was stirred at RT for 1 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (1.48 g, 84%).

(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (141-1; 1.48 g, 3.42 mmol), lithium hydroxide (20.5 mL, 1M in water), THF (61 mL) and MeOH (19 mL) was stirred at RT for 3 h. Citric acid (1.38 g) in water (20 mL) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (1.19 g, 77%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.32 (3H), 2.07 (3H), 2.41 (1H), 2.64 (1H), 2.85 (1H), 3.31 (1H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.37 (1H), 8.08 (1H), 8.21 (1H), 10.35 (1H), 11.95 (1H), 12.59 (1H)

Example 142 Methyl (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A solution of 4-fluorobenzoic acid (428 mg, 3.06 mmol) and HATU (1.16 g, 3.06 mmol) in DMF (2 mL) was added to a mixture of methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (31; 500 mg, 1.33 mmol) and DIPEA (532 μL, 3.06 mmol) in DMF (2 mL) and the reaction was stirred at 50° C. for 16 h. MeOH and EtOAc were added, the mixture washed with saturated sodium hydrogencarbonate solution, concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (603 mg, 91%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.55-2.63 (2H), 3.10-3.23 (2H), 3.37 (1H), 3.65 (3H), 6.58 (2H), 6.61 (1H), 7.03 (2H), 7.24 (1H), 7.36 (2H), 7.43 (1H), 8.11 (2H), 8.18 (1H), 8.34 (1H), 10.76 (1H), 12.08 (1H)

Example 143 Methyl (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbony0amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A solution of 1,3-thiazole-5-carboxylic acid (395 mg, 3.06 mmol) and HATU (1.16 g, 3.06 mmol) in DMF (2 mL) was added to a mixture of methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (31; 500 mg, 1.33 mmol) and DIPEA (532 μL, 3.06 mmol) in DMF (2 mL) and the reaction was stirred at 50° C. for 16 h. MeOH and EtOAc were added, the mixture washed with saturated sodium hydrogencarbonate solution, concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (645 mg, 90%).

¹H NMR (400 MHz, DMSO-d6) δ ppm 2.54-2.65 (2H), 3.09-3.22 (2H), 3.37 (1H), 3.64 (3H), 6.58 (2H), 6.61 (1H), 7.02 (2H), 7.25 (1H), 7.44 (1H), 8.20 (1H), 8.30 (1H), 8.88 (1H), 9.33 (1H), 11.12 (1H), 12.07 (1H)

Example 144 3,3-Dimethyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide

A mixture of 4-[(6RS)-6-ammonio-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridinium chloride (5; 40 mg, 102 μmol), 3,3-dimethylbutanoyl chloride (28 μL, 204 μmol) in pyridine (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (14 mg, 33%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.94 (9H), 1.96 (2H), 2.43 (1H), 2.52 (1H), 2.87 (1H), 3.15 (1H), 4.32 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 8.12 (1H), 8.42 (2H), 11.96 (1H)

Example 145 (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (142; 527 mg, 1.06 mmol), potassium hydroxide (4.2 mL, 4M in water), THF (4.2 mL) and MeOH (4.2 mL) was stirred at RT for 10 minutes. Hydrochloric acid (5.6 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (450 mg, 88%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.53-2.63 (2H), 3.08-3.27 (3H), 6.59 (2H), 6.61 (1H), 7.02 (2H), 7.24 (1H), 7.36 (2H), 7.43 (1H), 8.11 (2H), 8.18 (1H), 8.34 (1H), 10.75 (1H), 12.05 (1H), 12.62 (1H)

Example 146 (6RS)-Oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (143; 625 mg, 1.28 mmol), potassium hydroxide (5.1 mL, 4M in water), THF (5.1 mL) and MeOH (5.1 mL) was stirred at RT for 10 minutes. Hydrochloric acid (6.8 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (480 mg, 79%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.52-2.62 (2H), 3.07-3.26 (3H), 6.58 (2H), 6.61 (1H), 7.02 (2H), 7.25 (1H), 7.44 (1H), 8.20 (1H), 8.29 (1H), 8.88 (1H), 9.33 (1H), 11.11 (1H), 12.05 (1H), 12.62 (1H)

Example 147

N³-Methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]-beta-alaninamide trifluoroacetate

A solution of tert-butyl methyl(3-oxo-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7- tetrahydro-1H-indol-6-yl]aminopropyl)carbamate (137; 20 mg, 40 μmol) in TFA (2.5 mL) was stirred at RT for 1 h, concentrated and dried to give the title compound (23 mg, 100%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.47-2.58 (5H), 2.64 (1H), 2.93 (1H), 3.10 (2H), 3.24 (1H), 4.41 (1H), 6.72 (2H), 6.77 (1H), 7.13 (2H), 7.73 (2H), 8.06 (1H), 8.31 (2H), 8.57 (1H), 8.61 (2H), 12.50 (1H)

Example 148 (6RS)-N-[(1-Hydroxycyclobutyl)methyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), 1-(aminomethyl)cyclobutanol (52 mg, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (40 mg, 54%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.42 (1H), 1.61 (1H), 1.84-1.97 (4H), 2.37 (1H), 2.56 (1H), 2.94-3.10 (2H), 3.16-3.27 (3H), 5.17 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.45 (1H), 7.46 (2H), 7.97 (1H), 8.41 (2H), 11.96 (1H)

Example 149 (4E)-5-[(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid 149-1: N-{4-[(6RS)-3-Anilino-6-formyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl)}acetamide

A solution of ethanedioyl dichloride (196 μL, 2.25 mmol) in DCM (6 mL) was cooled to −78° C. DMSO (318 μL, 4.50 mmol) was added slowly followed by a solution of N-4-[(6RS)-6-(hydroxymethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (94; 350 mg, 896 μmol) in DCM (6 mL). The mixture was stirred at −78° C. for 1 h, Et ₃N (1.0 mL) was added and the mixture warmed to RT. Water was added, the mixture extracted with DCM/MeOH and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (69 mg, 20%).

(4E)-5-[(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid

To a solution of (3-carboxypropyl)(triphenyl)phosphonium bromide (790 mg, 1.84 mmol) in THF (12 mL) was added KO^(t)Bu (413 mg, 3.68 mmol) at 0° C. and the mixture stirred at 0° C. to RT for 0.5 h. A solution of N-{4-[(6RS)-3-Anilino-6-formyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide (149-1; 143 mg, 368 μmol) in THF (5 mL) was added at 0° C. and the mixture stirred for 2 h. Water and EtOAc were added, the mixture washed with brine and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 25 g, MeOH:DCM) followed ba preparative TLC (MeOH:DCM) to give the title compound (38 mg, 20%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.59 (1H), 2.06 (3H), 2.10-2.39 (6H), 2.69 (1H), 2.92 (1H), 5.34-5.44 (2H), 6.57 (2H), 6.60 (1H), 7.01 (2H), 7.17 (1H), 7.35 (1H), 8.08 (1H), 8.22 (1H), 10.33 (1H), 12.02 (1H)

Example 150 Methyl (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 150-1: Methyl (1RS)-3-({[3-(2,2-difluoroethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-5-oxo-4-(phenylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate (8-2; 863 mg, 2.83 mmol) and 1-[3-(2,2-difluoroethoxy)pyridin-4-yl]methanamine (638 mg, 3.39 mmol; commercially available e.g. from UkrOrgSynthesis Ltd.) in DMA (12 mL) was heated at 130° C. for 1 h. The mixture was concentrated and purified by Biotage (SNAP silica 50 g, EtOAc:Hexane) to give the title compound (660 mg, 49%).

Methyl (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-({[3-(2,2-difluoroethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (150-1; 510 mg, 1.07 mmol), hydrogen peroxide (34% in water, 193 μL, 2.15 mmol) in MeOH (7.9 mL) was heated at 80° C. for 1 h. The mixture was concentrated and purified by Biotage (SNAP silica 25 g, EtOAc:Hexane) to give the title compound (140 mg, 30%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.57-2.66 (2H), 3.10 (1H), 3.18 (1H), 3.37 (1H), 3.65 (3H), 4.33 (2H), 6.33 (1H), 6.51 (2H), 6.57 (1H), 6.96 (2H), 7.29 (1H), 7.44 (1H), 8.13 (1H), 8.38 (1H), 11.40 (1H)

Example 151 N-4-[(6RS)-6-(Azidomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide 151-1: [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate

A solution of N-4-[(6RS)-6-(hydroxymethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (94; 1.18 g, 3.01 mmol), DMAP (37 mg, 0.3 mmol) and methanesulfonyl chloride (280 μL, 3.61 mmol) in pyridine (16 mL) was stirred at RT for 5 h. MeOH was added, the mixture concentrated and purified by crystallization from MeOH to give the title compound (1.26 g, 90%).

N-4-[(6RS)-6-(Azidomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 200 mg, 427 μmol), sodium azide (278 mg, 4.27 mmol) in DMA (8 mL) was stirred at 60° C. for 16 h. The mixture was filtered, concentrated and purified by Biotage (SNAP silica 10 g, MeOH:DCM) to give the title compound (164 mg, 88%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.28 (1H), 2.35 (1H), 2.47 (1H), 2.69 (1H), 3.02 (1H), 3.50 (2H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.36 (1H), 8.08 (1H), 8.23 (1H), 10.35 (1H), 11.97 (1H)

Example 152 (6RS)-N-(2-Methoxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (89 μL, 518 μmol), 2-methoxy-N-methylethanamine (56 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (45 mg, 59%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.27-2.35 (1H), 2.47-2.57 (1H), 2.86+3.09 (3H), 2.91-3.06 (2H), 3.25+3.27 (3H), 3.39-3.51 (3H), 3.56-3.70 (2H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.42-7.48 (3H), 8.41 (2H), 11.95 (1H)

Example 153 (6RS)-2-[2-([rel-(1R,2R)-2-Fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (140; 60 mg, 134 μmol), DMF (2 mL), DIPEA (70 μL, 401 μmol), 2-(methylamino)ethanol (32 μL, 401 μmol) and T3P (120 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (38 mg, 56%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.64 (1H), 2.20 (1H), 2.32 (1H), 2.46-2.57 (1H), 2.85+3.10 (3H), 2.92-3.03 (2H), 3.28-3.55 (4H), 3.61+3.70 (1H), 4.55-4.95 (1H), 4.85+5.02 (1H), 6.58 (2H), 6.61 (1H), 7.02 (2H), 7.16 (1H), 7.36+7.37 (1H), 8.08 (1H), 8.26 (1H), 10.73 (1H), 11.98 (1H)

Example 154 (6RS)-2-[2-([rel-(1R,2R)-2-Fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (140; 60 mg, 134 μmol), DMF (2 mL), DIPEA (70 μL, 401 μmol), N-methylmethanamine (201 μL, 2M in THF) and T3P (124 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (37 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.64 (1H), 2.20 (1H), 2.31 (1H), 2.49 (1H), 2.85 (3H), 2.92-3.03 (2H), 3.06 (3H), 3.64 (1H), 4.93 (1H), 6.58 (2H), 6.61 (1H), 7.02 (2H), 7.15 (1H), 7.37 (1H), 8.08 (1H), 8.26 (1H), 10.73 (1H), 11.98 (1H)

Example 155 (6RS)-N-(2,2-Dimethylpropyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (180 μL, 1.04 mmol), N,2,2-trimethylpropan-1-amine hydrochloride (71 mg, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (59 mg, 79%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.88+0.92 (9H), 2.24+2.36 (1H), 2.42-2.61 (1H), 2.91+3.14 (3H), 2.95-3.07 (2H), 3.13-3.30 (2H), 3.68 (1H), 6.59 (2H), 6.63 (1H), 7.5 (2H), 7.44 (1H), 7.46 (2H), 8.41 (2H), 11.95 (1H)

Example 156 N-4-[(6RS)-6-(Aminomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of N-4-[(6RS)-6-(azidomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (151; 155 mg, 373 μmol), triphenylphosphine (218 mg, 832 μmol) ammonia (798 μL, 25% in water) in THF (5.5 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 28 g, MeOH:DCM) to give the title compound (129 mg, 86%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.16-2.26 (2H), 2.36 (1H), 2.58-2.67 (3H), 2.97 (1H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.35 (1H), 8.07 (1H), 8.22 (1H), 10.34 (1H), 11.91 (1H)

Example 157 Methyl (6RS)-3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 157-1: Methyl 3-({[3-(cyclopropylmethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-3-hydroxy-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (8-2; 50 mg, 164 μmol) and 1-[3-(cyclopropylmethoxy)pyridin-4-yl]methanamine (157-2; 25 mg, 196 μmol; commercially available e.g. from UkrOrgSynthesis Ltd.) in DMA (0.7 mL) was heated at 1300 for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (75 mg, 98%).

Methyl (6RS)-3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl 3-({[3-(cyclopropylmethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (157-1; 450 mg, 967 μmol), hydrogen peroxide (34% in water, 174 μL, 1.93 mmol) in MeOH (7.1 mL) was heated at 90° C. for 5.5 h. Saturated sodium thiosulphate solution was added, the mixture concentrated and purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (110 mg, 26%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.34 (2H), 0.56 (2H), 1.29 (1H), 2.54-2.65 (2H), 3.07-3.21 (2H), 3.36 (1H), 3.65 (3H), 3.94 (2H), 6.52 (2H), 6.57 (1H), 6.97 (2H), 7.27 (1H), 7.36 (1H), 8.04 (1H), 8.33 (1H), 11.37 (1H)

Example 158 (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (157; 104 mg, 241 μmol), potassium hydroxide (964 μL, 4M in water), THF (1 mL) and MeOH (1 mL) was stirred at RT for 10 minutes. Hydrochloric acid (1.26 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (45 mg, 45%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.34 (2H), 0.56 (2H), 1.29 (1H), 2.49-2.63 (2H), 3.06-3.18 (2H), 3.24 (1H), 3.93 (2H), 6.52 (2H), 6.57 (1H), 6.97 (2H), 7.28 (1H), 7.39 (1H), 8.05 (1H), 8.32 (1H), 11.35 (1H), 12.58 (1H)

Example 159 (6RS)-2-[3-(Cyclopropylmethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (158; 30 mg, 72 μmol), DMF (0.8 mL), DIPEA (38 μL, 216 μmol), 2-(methylamino)ethanol (17 μL, 216 μmol) and T3P (65 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (32 mg, 94%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.35 (2H), 0.56 (2H), 1.29 (1H), 2.30-2.37 (1H), 2.48-2.58 (1H), 2.86+3.11 (3H), 2.92-3.04 (2H), 3.31-3.56 (4H), 3.65+3.73 (1H), 3.88-3.97 (2H), 4.68+4.85 (1H), 6.54 (2H), 6.57 (1H), 6.98 (2H), 7.27 (1H), 7.36+7.37 (1H), 8.04 (1H), 8.31 (1H), 11.31 (1H)

Example 160 Methyl (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 160-1: Methyl (1RS)-3-({[3-(2-methoxyethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-3-hydroxy-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (8-2; 700 mg, 2.29 mmol) and 1-[3-(2-methoxyethoxy)pyridin-4-yl]methanamine (160-2; 584 mg, 3.21 mmol; commercially available e.g. from UkrOrgSynthesis Ltd.) in DMA (10 mL) was heated at 130° C. for 1 h. The mixture was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (515 mg, 48%).

Methyl (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-({[3-(2-methoxyethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (160-1; 460 mg, 980 μmol), hydrogen peroxide (34% in water, 177 μL, 1.96 mmol) in MeOH (7.2 mL) was heated at 90° C. for 5.5 h. Saturated lo sodium thiosulphate solution was added, the mixture concentrated and purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (165 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.54-2.66 (2H), 3.07-3.20 (2H), 3.36 (1H), 3.38 (3H), 3.65 (3H), 3.75 (2H), 4.28 (2H), 6.53 (2H), 6.58 (1H), 6.98 (2H), 7.30 (1H), 7.39 (1H), 8.05 (1H), 8.39 (1H), 11.28 (1H)

Example 161 (6RS)-3-Anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (160; 121 mg, 278 μmol), potassium hydroxide (1.11 mL, 4M in water), THF (1.1 mL) and MeOH (1.1 mL) was stirred at RT for 10 minutes. Hydrochloric acid (1.5 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (100 mg, 85%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.51-2.63 (2H), 3.06-3.17 (2H), 3.24 (1H), 3.39 (3H), 3.75 (2H), 4.29 (2H), 6.53 (2H), 6.58 (1H), 6.98 (2H), 7.30 (1H), 7.40 (1H), 8.04 (1H), 8.39 (1H), 11.25 (1H), 12.60 (1H)

Example 162 (6RS)-2-[3-(2-Methoxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (161; 30 mg, 71 μmol), DMF (1.1 mL), DIPEA (37 μL, 213 μmol), N-methylmethanamine (107 μL, 2M in THF) and T3P (64 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (30 mg, 94%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.51 (1H), 2.85 (3H), 2.91-3.05 (2H), 3.07 (3H), 3.38 (3H), 3.68 (1H), 3.75 (2H), 4.29 (2H), 6.56 (2H), 6.59 (1H), 6.99 (2H), 7.30 (1H), 7.39 (1H), 8.04 (1H), 8.39 (1H), 11.20 (1H)

Example 163 (6RS)-N-(2-Hydroxyethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-N-methyl-4-oxo-3-(phenylamine)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (161; 30 mg, 71 μmol), DMF (0.8 mL), DIPEA (37 μL, 213 μmol), 2-(methylamino)ethanol (16 mg, 214 μmol) and T3P (64 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (30 mg, 88%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.30-2.38 (1H), 2.48-2.59 (1H), 2.86+3.11 (3H), 2.91-3.06 (2H), 3.31-3.56 (4H), 3.38 (3H), 3.61-3.77 (3H), 4.28 (2H), 4.68+4.86 (1H), 6.55 (2H), 6.59 (1H), 6.99 (2H), 7.29-7.33 (1H), 7.39 (1H), 8.04 (1H), 8.39 (1H), 11.21 (1H)

Example 164 Methyl (6RS)-3-anilino-2-[3-(2-hydroxyethoxy)pyridi n -4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 164-1: Methyl (1RS)-3-({[3-(2-hydroxyethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-3-hydroxy-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (8-2; 1.51 g, 4.95 mmol) and 2-{[4-(aminomethyl)pyridin-3-yl]oxy}ethanol (164-2; 1.00 g, 5.95 mmol; commercially available e.g. from UkrOrgSynthesis Ltd.) in DMA (2 mL) was heated at 130′C for 5 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, MeOH:DCM) to give the title compound (352 mg, 16%).

Methyl (6RS)-3-anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-({[3-(2-hydroxyethoxy)pyridin-4-yl]methyl}amino)-5-oxo-4-(phenylcarbamothioyl)cyclohex-3-ene-1-carboxylate (164-1; 387 mg, 850 μmol), hydrogen peroxide (34% in water, 153 μL, 1.70 mmol) in MeOH (5 mL) was heated at 90° C. for 24 h. The mixture was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (133 mg, 37%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.53-2.65 (2H), 3.04-3.19 (2H), 3.37 (1H), 3.65 (3H), 3.84 (2H), 4.25 (2H), 5.61 (1H), 6.55 (2H), 6.58 (1H), 6.99 (2H), 7.31 (1H), 7.44 (1H), 8.02 (1H), 8.42 (1H), 11.59 (1H)

Example 165 (6RS)-2-[3-(2-Hydroxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl methyl (6RS)-3-anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (164; 255 mg, 605 μmol), potassium hydroxide (2.42 mL, 4M in water), THF (2.4 mL) and MeOH (2.4 mL) was stirred at RT for 10 minutes. Hydrochloric acid (3.2 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (149 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.48-2.63 (2H), 3.03-3.16 (2H), 3.23 (1H), 3.85 (2H), 4.25 (2H), 5.61 (1H), 6.56 (2H), 6.59 (1H), 6.99 (2H), 7.31 (1H), 7.44 (1H), 8.02 (1H), 8.42 (1H), 11.57 (1H), 12.62 (1H)

Example 166 (6RS)-2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,74etrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (150; 510 mg, 1.07 mmol), hydrogen peroxide (34% in water, 193 μL, 2.15 mmol) in MeOH (7.9 mL) was heated at 90C for 1 h. The mixture was concentrated and purified by Biotage (SNAP silica 25 g, MeOH:DCM) to give the title compound (290 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.53-2.66 (2H), 3.06-3.21 (2H), 3.37 (1H), 3.65 (3H), 4.33 (2H), 6.33 (1H), 6.51 (2H), 6.57 (1H), 6.96 (2H), 7.29 (1H), 7.44 (1H), 8.13 (1H), 8.38 (1H), 11.40 (1H)

Example 167 (6RS)-N-Ethyl-N-(2-hydroxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), 2-(ethylamino)ethanol (51 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (51 mg, 67%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03+1.12 (3H), 1.47+1.75 (1H), 2.27+2.32 (1H), 2.48-2.60 (1H), 2.89-3.53 (7H), 3.57+3.68 (1H), 4.70+4.85 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.96 (1H)

Example 168 (6RS)-N-(2-Hydroxyethyl)-4-oxo-3-(phenylamino)-N-(propan-2-yl)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), 2-(isopropylamino)ethanol (83 μL, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (13 mg, 16%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.91-1.17 (6H), 1.41-1.56 (2H), 2.26+2.30 (1H), 2.46-2.59 (2H), 2.89-3.70 (5H), 4.21+4.46 (1H), 6.56-6.66 (3H), 7.05 (2H), 7.43-7.49 (3H), 8.42 (2H), 11.96+11.99 (1H)

Example 169 (6RS)-N-[(1-Hydroxycyclobutyl)methyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), 1-[(methylamino)methyl]cyclobutanol (60 mg, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (52 mg, 61%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.42-2.06 (6H), 2.27-2.37 (1H), 2.45-2.59 (1H), 2.90-3.08 (2H), 2.93+3.16 (3H), 3.45-3.54 (2H), 3.65-3.81 (1H), 5.18+5.32 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.43+7.44 (1H), 7.46 (2H), 8.41 (2H), 11.95 (1H)

Example 170 (6RS)-N-[(2R)-1-Hydroxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol), DMF (2 mL), DIPEA (90 μL, 518 μmol), (2R)-2-(methylamino)propan-1-ol (65 mg, 518 μmol) and T3P (156 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (22 mg, 27%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.97+1.08 (3H), 2.23-2.62 (4H), 2.68+2.90 (3H), 2.92-3.09 (2H), 3.37-3.47 (1H), 3.57-3.74 (1H), 4.07+4.54 (1H), 6.56-6.66 (3H), 7.05 (2H), 7.41-7.50 (3H), 8.39-8.43 (2H), 11.96+12.03 (1H)

Example 171 (6RS)-N-[(2S)-1-Hydroxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-3-anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 115 μmol), DMF (2 mL), DIPEA (60 μL, 345 μmol), (2S)-2-(methylamino)propan-1-ol (65 mg, 345 μmol) and T3P (104 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (22 mg, 41%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.97+1.08 (3H), 2.23-2.59 (4H), 2.68+2.90 (3H), 2.92-3.11 (2H), 3.36-3.45 (1H), 3.58-3.75 (1H), 4.08+4.54 (1H), 6.55-6.66 (3H), 7.05 (2H), 7.41-7.49 (3H), 8.39-8.43 (2H), 11.95+12.00 (1H)

Example 172 N-(4-{(6RS)-3-Anilino-6-methyl-6-[(4-methylpiperazin-1-yl)carbonyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol), EtOAc (4 mL), DIPEA (62 μL, 358 μmol), 1-methylpiperazine (80 μL, 717 μmol) and T3P (142 μL, 50% in DMF) was stirred at 40° C. for 16 h. Water was added, the mixture extract ed with EtOAc and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 11 g, MeOH:DCM) and digestion with ether to give the title compound (26 mg, 41%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.40 (3H), 2.07 (3H), 2.16 (3H), 2.25 (4H), 2.44 (1H), 2.73 (1H), 2.93 (1H), 3.43 (1H), 3.51 (4H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.35 (1H), 8.07 (1H), 8.21 (1H), 10.35 (1H), 11.87 (1H)

Example 173 (6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol), EtOAc (4 mL), DIPEA (62 μL, 358 μmol), N-methylmethanamine (358 μL, 2M in THF) and T3P (142 μL, 50% in DMF) was stirred at 40° C. for 16 h. Water was added, the mixt ure extracted with EtOAc and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 11 g, MeOH:DCM) and preparative TLC (MeOH:DCM) to give the title compound (24 mg, 43%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.40 (3H), 2.07 (3H), 2.45 (1H), 2.78 (1H), 2.91 (1H), 2.94 (6H), 3.51 (1H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.13 (1H), 7.36 (1H), 8.07 (1H), 8.21 (1H), 10.35 (1H), 11.87 (1H)

Example 174 N-{4-[(6RS)-3-Anilino-6-{[(2R,63)-2,6-dimethylmorpholin-4-yl]carbonyl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol), EtOAc (4 mL), DIPEA (62 μL, 358 μmol), (2R,6S)-2,6-dimethylmorpholine (44 μL, 358 μmol) and T3P (142 μL, 50% in DMF) was stirred at 40° C. for 16 h. Water was added, the mixture extracted with EtOAc and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 11 g, MeOH:DCM) and preparative TLC (MeOH:DCM) to give the title compound (18 mg, 28%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.09 (6H), 1.41 (3H), 2.07 (3H), 2.46 (1H), 2.73 (1H), 2.95 (1H), 3.28-3.47 (5H), 4.12 (2H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.15 (1H), 7.34 (1H), 8.08 (1H), 8.20 (1H), 10.35 (1H), 11.87 (1H)

Example 175 N-(4-{(6RS)-3-Anilino-6-[(3-fluoroazetidin-1-yl)carbonyl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indole-6-carboxylic acid (141; 50 mg, 119 μmol), EtOAc (4 mL), DIPEA (62 μL, 358 μmol), 3-fluoroazetidine (40 mg, 358 μmol) and T3P (142 μL, 50% in DMF) was stirred at 40° C. for 16 h. Water was added, the mixture extract ed with EtOAc and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 11 g, MeOH:DCM) and digestion with ether to give the title compound (25 mg, 42%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.30 (3H), 2.07 (3H), 2.47 (1H), 2.64 (1H), 2.81 (1H), 3.39 (1H), 3.84 (1H), 4.13 (1H), 4.44 (1H), 4.71 (1H), 5.36 (1H), 6.54 (2H), 6.59 (1H), 7.01 (2H), 7.15 (1H), 7.39 (1H), 8.09 (1H), 8.21 (1H), 10.36 (1H), 11.92 (1H)

Example 176 N-(4-{(6RS)-3-Anilino-6-[(3,3-difluoroazetidin-1-yl)carbonyl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide

A mixture comprising (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol), EtOAc (4 mL), DIPEA (62 μL, 358 μmol), 3,3-difluoroazetidine (46 mg, 358 μmol) and T3P (142 μL, 50% in DMF) was stirred at 40° C. for 16 h. Water was added, the mixture extracted with EtOAc and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 11 g, MeOH:DCM) to give the title compound (22 mg, 36%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.33 (3H), 2.07 (3H), 2.54 (1H), 2.64 (1H), 2.85 (1H), 3.39 (1H), 4.32 (2H), 4.76 (2H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.15 (1H), 7.39 (1H), 8.09 (1H), 8.21 (1H), 10.37 (1H), 11.92 (1H)

Example 177 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-methoxyethyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (68 mg, 179 μmol) in DMA (1 mL) was added to a mixture of 2-methoxy-N-methylethanamine (16 μL, 143 μmol) and DIPEA (25 μL, 143 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (26 mg, 41%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.40 (3H), 2.07 (3H), 2.42 (1H), 2.75 (1H), 2.92 (1H), 3.08 (2H), 3.12 (3H), 3.22-3.41 (4H), 3.44-3.55 (2H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.13 (1H), 7.34 (1H), 8.07 (1H), 8.21 (1H), 10.34 (1H), 11.86 (1H)

Example 178 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,N-diethyl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (91 mg, 239 μmol) in DMA (1 mL) was added to a mixture of N-ethylethanaminium chloride (39 mg, 358 μmol) and DIPEA (125 μL, 717 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (23 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.01 (6H), 1.39 (3H), 2.07 (3H), 2.45 (1H), 2.72 (1H), 2.91 (1H), 3.30 (4H), 3.42 (1H), 6.53 (2H), 6.58 (1H), 6.99 (2H), 7.14 (1H), 7.33 (1H), 8.07 (1H), 8.20 (1H), 10.34 (1H), 11.87 (1H)

Example 179 N-4-[(6RS)-6-Methyl-6-(2-oxa-6-azaspiro[3.3]hept-6-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (91 mg, 239 μmol) in DMA (0.9 mL) was added to a mixture of 2-oxa-6-azaspiro[3.3]heptane (52 mg, 358 μmol) and DIPEA (167 μL, 956 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (14 mg, 23%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.27 (3H), 2.07 (3H), 2.45 (1H), 2.62 (1H), 2.78 (1H), 3.37 (1H), 3.97 (2H), 4.56 (2H), 4.64 (4H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.37 (1H), 8.08 (1H), 8.21 (1H), 10.35 (1H), 11.90 (1H)

Example 180 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-2-methoxypropyl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide 180-2: tert-Butyl [(2S)-2-methoxypropyl]methylcarbamate

From 1.83 g sodium hydride (60%) the mineral oil was removed and THF (60 mL) was added followed by iodomethane (2.84 mL, 45.7 mmol) and tert-butyl [(2R)-2-hydroxypropyl]carbamate (CAS-No: 119768-44-4; 2.00 g, 11.4 mmol) solved in THF (10 mL). The mixture was stirred at RT for 4 h, methanol was added and the solvents were removed. Dichloromethane was added, the suspension was filtered through silica gel and concentrated to give 960 mg (34%) of the title compound.

180-1: (2S)-2-Methoxy-N-methylpropan-1-aminium chloride

A mixture comprising tert-butyl [(2S)-2-methoxypropyl]methylcarbamate (180-2; 960 mg, 4.72 mmol) and hydrochloric acid (14 mL, 4M in dioxane) was heated at 50° C. for 16 hours. The solvents were removed, the residue digested with diethyl ether and the precipitate was dried to give 425 mg (61%) of the title compound.

(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-2-methoxypropyl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1 H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (91 mg, 239 μmol) in DMA (0.9 mL) was added to a mixture of (2S)-2-methoxy-N-methylpropan-1-aminium chloride (180-1; 50 mg, 358 μmol) and DIPEA (125 μL, 717 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (20 mg, 31%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.80+0.83 (3H), 1.41 (3H), 2.07 (3H), 2.38 (1H), 2.76 (1H), 2.94 (1H), 3.03+3.08 (3H), 3.10-3.32 (5H), 3.37+3.46 (1H), 3.54+3.58 (1H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.12 (1H), 7.31+7.32 (1H), 8.06 (1H), 8.19 (1H), 10.34 (1H), 11.85+11.86 (1H)

Example 181 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-1-methoxypropan-2-yl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide 181-2: tert-Butyl [(2S)-1-methoxypropan-2-yl]methylcarbamate

From 1.83 g sodium hydride (60%) the mineral oil was removed, THF (60 mL) was added followed by iodomethane (2.84 mL, 45.7 mmol) and tert-butyl [(2S)-1-methoxypropan-2-yl]methylcarbamate (CAS-No: 167938-56-9; 2.00 g, 11.4 mmol) solved in THF (10 mL). The mixture was stirred at RT for 4 h, methanol was added and the solvents were removed. Dichloromethane was added, the suspension was filtered through silica gel and concentrated to give 1.00 g (38%) of the title compound.

181-1: (2S)-1-Methoxy-N-methylpropan-2-aminium chloride

A mixture comprising tert-butyl [(2S)-1-methoxypropan-2-yl]methylcarbamate (180-2; 1.00 g, 4.92 mmol) and hydrochloric acid (12.3 mL, 4M in dioxane) was heated at 50° C. for 16 hours. The solvents were removed, the residue digested with diethyl ether and the precipitate was dried to give 446 mg (62%) of the title compound.

(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-1-methoxypropan-2-yl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (91 mg, 239 μmol) in DMA (0.9 mL) was added to a mixture of (2S)-1-methoxy-N-methylpropan-2-aminium chloride (181-1; 50 mg, 358 μmol) and DIPEA (125 μL, 717 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (22 mg, 34%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.01 (3H), 1.41 (3H), 2.07 (3H), 2.39+2.47 (1H), 2.63-3.55 (11H), 4.39+4.45 (1H), 6.53 (2H), 6.58 (1H), 6.99 (2H), 7.13 (1H), 7.33 (1H), 8.07 (1H), 8.20 (1H), 10.34 (1H), 11.85 (1H)

Example 182 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-methoxy-2-methylpropyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (91 mg, 239 μmol) in DMA (1 mL) was added to a mixture of 2-methoxy-N,2-dimethylpropan-1-aminium chloride (30 mg, 195 μmol) and DIPEA (83 μL, 479 μmol) in DMA (1 mL) and the reaction was stirred at RT for 6 h and at 50° C. for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (10 mg, 16%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.69 (3H), 0.85 (3H), 1.43 (3H), 2.07 (3H), 2.38 (1H), 2.77 (1H), 2.95 (1H), 3.03 (4H), 3.22 (3H), 3.54-3.62 (2H), 6.53 (2H), 6.60 (1H), 6.99 (2H), 7.09 (1H), 7.29 (1H), 8.05 (1H), 8.18 (1H), 10.34 (1H), 11.84 (1H)

Example 183 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,6-dimethyl-4-oxo-3-(phenylamino)-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1 H-indol-6-carboxylic acid (141; 50 mg, 119 μmol) and HATU (91 mg, 239 μmol) in DMA (1 mL) was added to a mixture of N-methylpropan-1-amine (18 μL, 179 μmol) and DIPEA (62 μL, 358 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (19 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.69 (3H), 1.37 (2H), 1.40 (3H), 2.07 (3H), 2.42 (1H), 2.76 (1H), 2.91 (1H), 2.99 (3H), 3.11 (1H), 3.29 (1H), 3.51 (1H), 6.53 (2H), 6.59 (1H), 6.99 (2H), 7.13 (1H), 7.32 (1H), 8.07 (1H), 8.20 (1H), 10.35 (1H), 11.85 (1H)

Example 184 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2,2-dimethylpropyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 45 mg, 108 μmol) and HATU (82 mg, 215 μmol) in DMA (1 mL) was added to a mixture of N,2,2-trimethylpropan-1-aminium chloride (44 mg, 323 μmol) and DIPEA (112 μL, 645 μmol) in DMA (1 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (23 mg, 40%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.63 (9H), 1.42 (3H), 2.07 (3H), 2.39 (1H), 2.79 (2H), 2.92 (1H), 3.22 (3H), 3.39 (1H), 3.60 (1H), 6.54 (2H), 6.59 (1H), 6.99 (2H), 7.06 (1H), 7.28 (1H), 8.05 (1H), 8.18 (1H), 10.33 (1H), 11.83 (1H)

Example 185 N-4-[(6RS)-6-[(3R)-3-(Dimethylamino)pyrrolidin-1-yl]carbonyl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 45 mg, 108 μmol) and HATU (82 mg, 215 μmol) in DMA (1 mL) was added to a mixture of (3R)-N,N-dimethylpyrrolidin-3-amine (41 μL, 323 μmol) and DIPEA (56 μL, 323 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (15 mg, 26%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.34 (3H), 1.85-3.55 (10H) 2.07 (3H), 2.15 (6H), 3.85 (1H), 6.52 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.36 (1H), 8.08 (1H), 8.21 (1H), 10.34+10.35 (1H), 11.87 (1H)

Example 186 N-4-[(6RS)-6-Methyl-6-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 45 mg, 108 μmol) and HATU (82 mg, 215 μmol) in DMA (1 mL) was added to a mixture of (1R,4R)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride (60 mg, 323 μmol) and DIPEA (169 μL, 968 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (11 mg, 19%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.34 (3H), 1.41-1.86 (2H), 2.07 (3H), 2.23+2.25 (3H), 2.35-2.61 (2H), 2.69-3.86 (7H), 4.36-4.83 (1H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.34 (1H), 8.08 (1H), 8.21 (1H), 10.34+10.35 (1H), 11.88+11.90 (1H)

Example 187 (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,6-dimethyl-N-(2-methylpropy0-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 45 mg, 108 μmol) and HATU (82 mg, 215 μmol) in DMA (1 mL) was added to a mixture of N,2-dimethylpropan-1-amine (39 μL, 323 μmol) and DIPEA (56 μL, 323 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (16 mg, 29%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.55 (3H), 0.67 (3H), 1.41 (3H), 1.72 (1H), 2.07 (3H), 2.38 (1H), 2.77 (1H), 2.81 (1H), 2.92 (1H), 3.10 (3H), 3.25 (1H), 3.56 (1H), 6.53 (2H), 6.59 (1H), 6.99 (2H), 7.11 (1H), 7.29 (1H), 8.06 (1H), 8.19 (1H), 10.34 (1H), 11.84 (1H)

Example 188 N-4-[(6RS)-6-Methyl-6-[(1 R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylcarbonyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A solution of (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (141; 45 mg, 108 μmol) and HATU (82 mg, 215 μmol) in DMA (1 mL) was added to a mixture of (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride (44 mg, 323 μmol) and DIPEA (112 μL, 645 μmol) in DMA (1 mL) and the reaction was stirred at RT for 3 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (24 mg, 42%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.37 (3H), 1.53-1.87 (2H), 2.07 (3H), 2.38-2.59 (2H), 2.74 (1H), 2.89-3.85 (5H), 4.49-5.12 (2H), 6.50-6.61 (3H), 7.00 (2H), 7.15 (1H), 7.36 (1H), 8.08 (1H), 8.21+8.22 (1H), 10.35+10.36 (1H), 11.89+11.91 (1H)

Example 189 N-4-[(6RS)-6-[(Ethylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium ethanethiolate (81 mg, 960 μmol) in DMA (2.3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (44 mg, 60%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.19 (3H), 2.07 (3H), 2.26 (1H), 2.35-2.47 (2H), 2.54 (2H), 2.59-2.70 (3H), 3.11 (1H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.14 (1H), 7.34 (1H), 8.06 (1H), 8.24 (1H), 10.32 (1H), 11.95 (1H)

Example 190

N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium propane-2-thiolate (94 mg, 960 μmol) in DMA (2.3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (43 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.22 (6H), 2.07 (3H), 2.25-2.39 (2H), 2.44 (1H), 2.60-2.72 (3H), 2.95 (1H), 3.13 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.35 (1H), 8.08 (1H), 8.23 (1H), 10.34 (1H), 11.95 (1H)

Example 191 N-4-[(6RS)-6-[(tert-Butylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium 2-methylpropane-2-thiolate (108 mg, 960 μmol) in DMA (3 mL) was stirred at 1001 for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (45 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.29 (9H), 2.07 (3H), 2.25-2.36 (2H), 2.40-2.48 (1H), 2.61-2.71 (3H), 3.11 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.35 (1H), 8.07 (1H), 8.23 (1H), 10.33 (1H), 11.94 (1H)

Example 192 (6RS)-2-(2-Aminopyriclin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfany0methyl]-1,5,6,7-tetrahydro-4H-indol-4-one 192-1: [(6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate

A solution of (6RS)-2-(2-aminopyridin-4-yl)-6-(hydroxymethyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one (87; 1.17 g, 3.34 mmol), DMAP (41 mg, 334 μmol) and methanesulfonyl chloride (311 μL, 4.01 mmol) in pyridine (18 mL) was stirred at RT for 4 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 110 g, MeOH:DCM) to give the title compound (1.27 g, 89%).

(6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6R⁵)-2-(2-aminopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (192-1; 512 mg, 1.20 mmol) and sodium propane-2-thiolate (707 mg, 7.20 mmol) in DMA (17 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by Biotage (SNAP silica 55 g, MeOH:DCM) to give the title compound (411 mg, 84%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.22 (6H), 2.26 (1H), 2.35 (1H), 2.42 (1H), 2.59-2.71 (3H), 2.94 (1H), 3.09 (1H), 5.74 (2H), 6.55 (2H), 6.58 (1H), 6.60 (1H), 6.69 (1H), 7.02 (2H), 7.22 (1H), 7.76 (1H), 11.71 (1H)

Example 193 (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(S)-propan-2-ylsulfinyl]methyl-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 714 mg, 1.76 mmol), mCPBA (741 mg, 75%) and DMA (50 mL) was stirred at RT for 16 h. TEA (1 mL) was added, the mixture concentrated and purified by Biotage (SNAP silica 55 g, MeOH:DCM) to give the title compound (246 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (6H), 2.39 (1H), 2.46 (1H), 2.63-2.90 (5H), 3.15 (1H), 5.84 (2H), 6.54-6.63 (4H), 6.71 (1H), 7.03 (2H), 7.26 (1H), 7.76 (1H), 11.78+11.81 (1H)

Example 194 (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfonAmethyl]-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture comprising (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 714 mg, 1.76 mmol), mCPBA (741 mg, 75%) and DMA (50 mL) was stirred at RT for 16 h. TEA (1mL) was added, the mixture concentrated and purified by Biotage (SNAP silica 55 g, MeOH:DCM) to give the title compound (173 mg, 21%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.26 (6H), 2.39 (1H), 2.48 (1H), 2.76-2.88 (2H), 3.20-3.33 (4H), 5.81 (2H), 6.54-6.63 (4H), 6.71 (1H), 7.03 (2H), 7.25 (1H), 7.76 (1H), 11.81 (1H)

Example 195 (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (145; 60 mg, 123 μmol), DMF (2 mL), DIPEA (65 μL, 372 μmol), N-methylmethanamine (186 μL, 2M in THF) and T3P (112 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (36 mg, 54%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.53 (1H), 2.86 (3H), 2.94-3.03 (2H), 3.07 (3H), 3.65 (1H), 6.59-6.64 (3H), 7.03 (2H), 7.24 (1H), 7.36 (2H), 7.41 (1H), 8.10 (2H), 8.18 (1H), 8.34 (1H), 10.74 (1H), 12.02 (1H)

Example 196 (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (145; 60 mg, 123 μmol), DMF (2 mL), DIPEA (65 μL, 372 μmol), 2-(methylamino)ethanol (30 μL, 372 μmol) and T3P (112 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (49 mg, 69%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.30-2.38 (1H), 2.46-2.58 (1H), 2.86+3.11 (3H), 2.93-3.07 (2H), 3.29-3.56 (4H), 3.60-3.76 (1H), 4.69+4.86 (1H), 6.59-6.64 (3H), 7.03 (2H), 7.24 (1H), 7.35 (2H), 7.41+7.42 (1H), 8.10 (2H), 8.18 (1H), 8.34 (1H), 10.74 (1H), 12.02 (1H)

Example 197 (6RS)-N,N-Dimethyl-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (146; 60 mg, 127 μmol), DMF (2 mL), DIPEA (66 μL, 380 μmol), N-methylmethanamine (190 μL, 2M in THF) and T3P (114 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (43 mg, 64%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.33 (1H), 2.53 (1H), 2.86 (3H), 2.93-3.03 (2H), 3.07 (3H), 3.66 (1H), 6.56-6.64 (3H), 7.03 (2H), 7.25 (1H), 7.42 (1H), 8.20 (1H), 8.29 (1H), 8.88 (1H), 9.33 (1H), 11.11 (1H), 12.02 (1H)

Example 198 (6RS)-N-(2-Hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (146; 60 mg, 127 μmol), DMF (2 mL), DIPEA (66 μL, 380 μmol), 2-(methylamino)ethanol (31 μL, 380 μmol) and T3P (114 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was filtered and purified by preparative HPLC (basic method) to give the title compound (49 mg, 69%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.34 (1H), 2.47-2.56 (1H), 2.86+3.11 (3H), 2.89-3.05 (3H), 3.19-3.76 (4H), 3.89 (1H), 6.57-6.64 (3H), 7.03 (2H), 7.25 (1H), 7.41+7.42 (1H), 8.19 (1H), 8.29 (1H), 8.88 (1H), 9.33 (1H), 11.12 (1H), 12.05 (1H)

Example 199 N-{4-[(6RS)-3-Anilino-6-{[(methylsulfonyl)amino]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture of N-4-[(6RS)-6-(aminomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (156; 40 mg, 103 μmol), methanesulfonyl chloride (16 μL, 205 μmol) in pyridine (1.2 mL) was stirred at RT for 16 h. MeOH was added, the mixture concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (36 mg, 70%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.25 (1H), 2.31-2.40 (2H), 2.65 (1H), 2.92 (3H), 2.99-3.07 (3H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.16 (1H), 7.21 (1H), 7.36 (1H), 8.08 (1H), 8.23 (1H), 10.35 (1H), 11.97 (1H)

Example 200 N-{4-[(6RS)-6-(Acetamidomethyl)-3-anilino-4-oxo-4,5,6,74etrahydro-1H-in do1-2-yl]pyridin-2-yl}acetamide

A mixture of N-4-[(6RS)-6-(aminomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (156; 40 mg, 103 μmol), acetyl chloride (15 μL, 205 μmol) in pyridine (1.2 mL) was stirred at RT for 16 h. MeOH was added, the mixture concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (28 mg, 59%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.85 (3H), 2.07 (3H), 2.22 (1H), 2.27-2.36 (2H), 2.59 (1H), 2.93 (1H), 3.10 (1H), 3.18 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.35 (1H), 8.00 (1H), 8.08 (1H), 8.22 (1H), 10.34 (1H), 11.95 (1H)

Example 202 5-[(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pentanoic acid

A mixture comprising (4E)-5-[(6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid (149; 27 mg, 59 μmol), Pd/C (6.3 mg, 10%), THF (1 mL) and EtOH (1.3 mL) was stirred under an atmosphere of hydrogen at RT for 16 h. After filtration the mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (9 mg, 32%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.29-1.45 (4H), 1.50 (2H), 2.06 (3H), 2.18 (4H), 2.31 (1H), 2.54 (1H), 2.97 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.35 (1H), 8.07 (1H), 8.22 (1H), 10.34 (1H), 11.93 (1H)

Example 203 (6RS)-3-Anilino-N,N-dlisopropyl-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (9; 60 mg, 173 μmol) and HATU (66 mg, 173 μmol) in DMA (1 mL) was added to a mixture of N-isopropylpropan-2-amine (73 μL, 518 μmol) and DIPEA (30 μL, 173 μmol) in DMA (1 mL) and the reaction was stirred at 50eC for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (16 mg, 22%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.17 (6H), 1.30 (6H), 2.24 (1H), 2.57 (1H), 2.90 (1H), 3.03 (1H), 3.42-3.61 (2H), 4.14 (1H), 6.59 (2H), 6.64 (1H), 7.08 (2H), 7.43 (1H), 7.46 (2H), 8.42 (2H), 11.93 (1H)

Example 204 (6RS)-3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising of (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (166; 30 mg, 70 μmol), DMF (1.1 mL), DIPEA (55 μL, 316 μmol), N-methylmethanamine (158 μL, 2M in THF) and T3P (95 μL, 50% in DMF) was stirred at RT for 2 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (5 mg, 16%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.32 (1H), 2.47-2.52 (1H), 2.84 (3H), 2.93 (1H), 2.99 (1H), 3.06 (3H), 3.66 (1H), 4.30 (2H), 6.30 (1H), 6.52 (2H), 6.55 (1H), 6.94 (2H), 7.28 (1H), 7.42 (1H), 8.11 (1H), 8.35 (1H), 11.34 (1H)

Example 205 (6RS)-3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising of (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (166; 30 mg, 70 μmol), DMF (0.8 mL), DIPEA (37 μL, 211 μmol), 2-(methylamino)ethanol (17 μL, 211 μmol) and T3P (63 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (10 mg, 29%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.32 (1H), 2.45-2.57 (1H), 2.84+3.10 (3H), 2.92 (1H), 3.00 (1H), 3.30-3.54 (4H), 3.64+3.72 (1H), 4.29 (2H), 4.67+4.83 (1H), 6.30 (1H), 6.51 (2H), 6.55 (1H), 6.95 (2H), 7.28 (1H), 7.42+7.43 (1H), 8.11 (1H), 8.35 (1H), 11.33+11.35 (1H)

Example 206 (6RS)-3-Anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-. 1H-indol-6-carboxamide

A mixture comprising of (6RS)-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (165; 50 mg, 123 μmol), DMF (1.8 mL), DIPEA (64 μL, 368 μmol), N-methylmethanamine (184 μL, 2M in THF) and T3P (114 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (8 mg, 14%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.34 (1H), 2.52 (1H), 2.87 (3H), 2.94 (1H), 3.00 (1H), 3.08 (3H), 3.68 (1H), 3.86 (2H), 4.26 (2H), 5.59 (1H), 6.59 (2H), 6.61 (1H), 7.01 (2H), 7.32 (1H), 7.43 (1H), 8.02 (1H), 8.42 (1H), 11.55 (1H)

Example 207 (6RS)-3-Anilino-2-[3-(2-hydroxyeth oxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A mixture comprising of (6RS)-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (165; 50 mg, 123 μmol), DMF (1.8 mL), DIPEA (64 μL, 368 μmol), 2-(methylamino)ethanol (30 μL, 368 μmol) and T3P (111 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (12 mg, 19%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.32-2.38 (1H), 2.49-2.59 (1H), 2.87+3.12 (3H), 2.93 (1H), 3.01 (1H), 3.29-3.55 (4H), 3.66+3.73 (1H), 3.85 (2H), 4.21-4.30 (2H), 4.67+4.83 (1H), 5.57 (1H), 6.56-6.63 (3H), 7.01 (2H), 7.33 (1H), 7.42+7.44 (1H), 8.02+8.03 (1H), 8.42 (1H), 11.55 (1H)

Example 208 (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1 H-indol-6-carboxamide

A mixture comprising of (6RS)-3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (158; 30 mg, 72 μmol), DMF (1.1 mL), DIPEA (38 μL, 216 μmol), N-methylmethanamine (108 μL, 2M in THF) and T3P (65 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (15 mg, 47%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.35 (2H), 0.56 (2H), 1.29 (1H), 2.32 (1H), 2.51 (1H), 2.86 (3H), 2.92-3.04 (2H), 3.07 (3H), 3.67 (1H), 3.93 (2H), 6.54 (2H), 6.57 (1H), 6.97 (2H), 7.27 (1H), 7.36 (1H), 8.04 (1H), 8.31 (1H), 11.30 (1H)

Example 209 Methyl (6RS)-3-anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A solution of methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (31; 150 mg, 398 μmol) and HATU (348 mg, 917 μmol) in DMF (1 mL) was added to a mixture of (1RS)-2,2-difluorocyclopropanecarboxylic acid (112 mg, 917 μmol) and DIPEA (160 μL, 917 μmol) in DMF (1 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 10 g, MeOH:DCM) to give the title compound (154 mg, 72%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.01 (2H), 2.53 (1H), 2.58 (1H), 2.98 (1H), 3.10 (1H), 3.18 (1H), 3.35 (1H), 3.64 (3H), 6.55 (2H), 6.61 (1H), 7.01 (2H), 7.19 (1H), 7.41 (1H), 8.12 (1H), 8.22 (1H), 10.90 (1H), 12.05 (1H)

Example 210 (6RS)-3-Anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-3-anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (209; 150 mg, 312 μmol), potassium hydroxide (1.25 mL, 4M in water), THF (1.2 mL) and MeOH (1.2 mL) was stirred at RT for 10 minutes. Hydrochloric acid (1.67 mL, 3M) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (111 mg, 77%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.91-2.06 (2H), 2.51-2.61 (2H), 2.98 (1H), 3.06-3.17 (2H), 3.22 (1H), 6.55 (2H), 6.61 (1H), 7.01 (2H), 7.18 (1H), 7.41 (1H), 8.11 (1H), 8.22 (1H), 10.89 (1H), 12.02 (1H), 12.59 (1H)

Example 211 (6RS)-3-Anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-le-6-carboxamide

A mixture comprising of (6RS)-3-Anilino-2-[2-({[(1 RS)-2,2-difluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (210; 55 mg, 118 μmol), DMF (1.5 mL), DIPEA (62 μL, 354 μmol), N-methylmethanamine (177 μL, 2M in THF) and T3P (106 μL, 50% in DMF) was stirred at RT for 1 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (24 mg, 39%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.01 (2H), 2.33 (1H), 2.48-2.56 (1H), 2.86 (3H), 2.94-3.04 (2H), 3.07 (3H), 3.33 (1H), 3.65 (1H), 6.59 (2H), 6.63 (1H), 7.03 (2H), 7.19 (1H), 7.37 (1H), 8.12 (1H), 8.23 (1H), 10.87 (1H), 11.97 (1H)

Example 212 N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfany0methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2yl)-4-fluoro-3-methoxybenzamide

A solution of 4-fluoro-3-methoxybenzoic acid (42 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and crystallization from MeOH to give the title compound (18 mg, 25%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.21 (6H), 2.29 (1H), 2.37 (1H), 2.44 (1H), 2.61-2.71 (3H), 2.94 (1H), 3.13 (1H), 3.93 (3H), 6.57 (2H), 6.60 (1H), 7.01 (2H), 7.23 (1H), 7.35 (1H), 7.39 (1H), 7.63 (1H), 7.84 (1H), 8.17 (1H), 8.34 (1H), 10.77 (1H), 12.00 (1H)

Example 213 N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-2-fluoro-2-methylpropanamide

A solution of 2-fluoro-2-methylpropanoic acid (26 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and crystallization from MeOH to give the title compound (17 mg, 27%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.21 (6H), 1.54 (3H), 1.58 (3H), 2.28 (1H), 2.36 (1H), 2.44 (1H), 2.59-2.70 (3H), 2.93 (1H), 3.12 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.22 (1H), 7.40 (1H), 8.11-8.14 (2H), 9.70 (1H), 11.98 (1H)

Example 214 1-(4-{(6RS)-3-Anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-3-cyclopropylurea

A mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 60 mg, 148 μmol), isocyanatocyclopropane (25 μL, 295 μmol) in pyridine (1.6 mL) was stirred at RT for 2.5 days. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) and crystallization from MeOH to give the title compound (10 mg, 13%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.41 (2H), 0.64 (2H), 1.20 (6H), 2.27 (1H), 2.34 (1H), 2.43 (1H), 2.56 (1H), 2.60-2.69 (3H), 2.93 (1H), 3.10 (1H), 6.54 (2H), 6.59 (1H), 6.98-7.03 (3H), 7.31 (1H), 7.53 (1H), 7.95 (1H), 8.03 (1H), 8.98 (1H), 11.87 (1H)

Example 215 1-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-3-cyclopropylurea

A mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (194; 30 mg, 68 μmol), isocyanatocyclopropane (11 μL, 137 μmol) in pyridine (0.8 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by crystallization from MeOH to give the title compound (21 mg, 55%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.41 (2H), 0.64 (2H), 1.25 (6H), 2.39 (1H), 2.50 (1H), 2.56 (1H), 2.76-2.86 (2H), 3.22-3.31 (4H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.02 (1H), 7.32 (1H), 7.54 (1H), 7.96 (1H), 8.03 (1H), 8.99 (1H), 11.96 (1H)

Example 216 N-{[(6RS)-3-Anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl}-L-alaninamide

A mixture comprising tert-butyl [(2S)-1-oxo-1-( [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylamino)propan-2-yl]carbamate (89; 54 mg, 107 μmol), TFA (124 μL, 1.61 mmol) and DCM (3.5 mL) was stirred at RT for 16 h. Ammonia (0.5 mL, 25% in water) and DMSO (3 mL) were added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (36 mg, 79%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.17 (3H), 2.24 (1H), 2.31 (1H), 2.38 (1H), 2.62 (1H), 2.72 (1H), 2.92 (1H), 3.13-3.27 (2H), 3.32 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.47 (2H), 8.02 (1H), 8.41 (2H), 11.93 (1H)

Example 217 (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide 217-2: Methyl (6RS)-3-anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A solution of (1S,2S)-2-fluorocyclopropanecarboxylic acid (373 mg, 3.59 mmol) and HATU (1.36 g, 3.59 mmol) in DMF (13 mL) was added to a mixture of methyl (6RS)-2-(2-aminopyridin-4-yl)-3-anilino-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (141-2; 700 mg, 1.79 mmol) and DIPEA (625 μL, 3.59 mmol) in DMF (13 mL) and the reaction was stirred at RT for 2.5 days. The mixture was concentrated and EtOAc was added. The mixture was washed with water, brine and dried over sodium sulfate. After filtration and removal of the solvent, the title compound (578 mg, 64%) was used without further purification.

217-1: (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-3-anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (217-2; 574 mg, 1.21 mmol), lithium hydroxide (7.2 mL, 1M in water), THF (21 mL) and MeOH (6.7 mL) was stirred at RT for 16 h. and at 50° C. for 3 h. Citric acid (486 mg) in water (10 mL) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (425 mg, 72%).

(6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,23)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of N-methylmethanamine (152 μL, 2M in THF) and DIPEA (53 μL, 305 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (25 mg, 48%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.40 (3H), 1.64 (1H), 2.20 (1H), 2.44 (1H), 2.77 (1H), 2.91 (1H), 2.94 (6H), 3.51 (1H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 7.01 (2H), 7.14 (1H), 7.37 (1H), 8.07 (1H), 8.24 (1H), 10.72 (1H), 11.89 (1H)

Example 218 (6RS)-3-Anilino-N,N-diethyl-2-[2-({[(1 S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of N-ethylethanaminium chloride (33 mg, 305 μmol) and DIPEA (106 μL, 610 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (22 mg, 40%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.01 (6H), 1.18 (1H), 1.39 (3H), 1.64 (1H), 2.20 (1H), 2.44 (1H), 2.72 (1H), 2.91 (1H), 3.30 (4H), 3.42 (1H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 6.99 (2H), 7.15 (1H), 7.35 (1H), 8.07 (1H), 8.23 (1H), 10.72 (1H), 11.90 (1H)

Example 219 (6RS)-3-Anilino-2-[2-({[(1 S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of N-methylpropan-1-amine (31 μL, 305 μmol) and DIPEA (53 μL, 305 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (16 mg, 29%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.69 (3H), 1.18 (1H), 1.37 (2H), 1.40 (3H), 1.64 (1H), 2.20 (1H), 2.42 (1H), 2.75 (1H), 2.91 (1H), 2.95-3.17 (4H), 3.29 (1H), 3.51 (1H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.13 (1H), 7.34 (1H), 8.07 (1H), 8.23 (1H), 10.72 (1H), 11.88 (1H)

Example 220 (6RS)-3-Anilino-2-[2-({[(1 S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N-isobutyl-N,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of N,2-dimethylpropan-1-amine (37 μL, 305 μmol) and DIPEA (53 μL, 305 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (16 mg, 27%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.55 (3H), 0.67 (3H), 1.18 (1H), 1.41 (3H), 1.58-1.77 (2H), 2.20 (1H), 2.38 (1H), 2.76 (1H), 2.82 (1H), 2.93 (1H), 3.10 (3H), 3.26 (1H), 3.57 (1H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 6.99 (2H), 7.11 (1H), 7.31 (1H), 8.06 (1H), 8.22 (1H), 10.71 (1H), 11.86 (1H)

Example 221 (6RS)-3-Anilino-N-(cyclopropylmethyl)-2-[2-({[(1 S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of cyclopropyl-N-methylmethanaminium chloride (37 mg, 305 μmol) and DIPEA (106 μL, 610 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (12 mg, 21%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.05 (1H), 0.13 (1H), 0.30 (1H), 0.36 (1H), 0.81 (1H), 1.18 (1H), 1.41 (3H), 1.64 (1H), 2.20 (1H), 2.42 (1H), 2.77 (1H), 2.92 (1H), 3.01-3.12 (4H), 3.25 (1H), 3.53 (1H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 6.99 (2H), 7.13 (1H), 7.35 (1H), 8.07 (1H), 8.23 (1H), 10.72 (1H), 11.89 (1H)

Example 222 (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of 3,3,3-trifluoro-N-methylpropan-1-aminium chloride (50 mg, 305 μmol) and DIPEA (106 μL, 610 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (30 mg, 49%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.39 (3H), 1.64 (1H), 2.20 (1H), 2.27-2.39 (2H), 2.43 (1H), 2.75 (1H), 2.94 (1H), 3.13 (3H), 3.32 (1H), 3.44-3.55 (2H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 6.99 (2H), 7.15 (1H), 7.34 (1H), 8.07 (1H), 8.24 (1H), 10.72 (1H), 11.89 (1H)

Example 223 (1S,2S)-N-{4-[(6RS)-3-Anilino-6-methyl-4-oxo-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1 H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of pyrrolidine (25 μL, 305 μmol) and DIPEA (53 μL, 305 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (26 mg, 46%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.33 (3H), 1.64 (1H), 1.78 (4H), 2.20 (1H), 2.47 (1H), 2.80 (1H), 2.86 (1H), 3.10-3.81 (5H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.15 (1H), 7.38 (1H), 8.08 (1H), 8.24 (1H), 10.72 (1H), 11.90 (1H)

Example 224 (1S,2S)-N-{4-[(6RS)-3-Anilino-6-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of (3R)-N,N-dimethylpyrrolidin-3-amine (39 μL, 305 μmol) and DIPEA (53 μL, 305 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (18 mg, 30%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.34 (3H), 1.46-1.80 (2H), 1.83-2.25 (2H), 2.15 (6H), 2.41 (1H), 2.77 (1H), 2.92 (1H), 2.98-3.99 (6H), 4.93 (1H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.38 (1H), 8.08 (1H), 8.24 (1H), 10.73 (1H), 11.89 (1H)

Example 225 (1S,2S)-N-{4-[(6RS)-3-Anilino-6-methyl-4-oxo-6-(piperidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1 H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide

A solution of (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (217-1; 47 mg, 102 μmol) and HATU (77 mg, 203 μmol) in DMA (0.9 mL) was added to a mixture of piperidine (30 μL, 305 μmol) and DIPEA (53 μL, 305 μmol) in DMA (0.9 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (31 mg, 55%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.18 (1H), 1.40 (3H), 1.44 (4H), 1.53-1.70 (3H), 2.20 (1H), 2.44 (1H), 2.73 (1H), 2.93 (1H), 3.39-3.53 (5H), 4.93 (1H), 6.53 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.36 (1H), 8.07 (1H), 8.24 (1H), 10.72 (1H), 11.90 (1H)

Example 226 N-{4-[(6RS)-3-Anilino-6-({[2-(dimethylamino)ethyl]sulfanyl}methyl)-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl]pyridin-2-yl}acetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium 2-(dimethylamino)ethanethiolate (122 mg, 960 μmol) in DMA (3 mL) was stirred at 1001 for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (7 mg, 9%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.14 (6H), 2.27 (1H), 2.35-2.49 (4H), 2.59-2.71 (5H), 3.13 (1H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.35 (1H), 8.08 (1H), 8.23 (1H), 10.34 (1H), 11.95 (1H)

Example 227 N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-4-fluoro-N-methylbenzamide

A mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (194; 30 mg, 68 μmol) and (4-fluorophenyl)methylcarbamic chloride (26 mg, 137 μmol) in pyridine (0.8 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (9 mg, 21%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.26 (6H), 2.41 (1H), 2.53 (1H), 2.75-2.89 (2H), 3.23-3.32 (4H), 3.26 (3H), 6.57 (2H), 6.62 (1H), 7.03 (2H), 7.10 (1H), 7.29 (2H), 7.36 (1H), 7.41 (2H), 7.92 (1H), 7.95 (1H), 8.04 (1H), 12.03 (1H)

Example 228 (6RS)-2-(2-Aminopyridin-4-yl)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one 228-2: (4RS)-2-{[(2-Aminopyridin-4-yl)methyl]amino}-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide

A solution of (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenyl-2-[(pyridin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamide (30-3; 9.9 g, 18.7 mmol) and 4-(aminomethyl)pyridin-2-amine (4.14 g, 33.6 mmol) in DMA (52 mL) was heated at 90-100° C. for 10 h. The mixture was poured into water, extracted with EtOAc, washed with brine and dried over sodium sulfate. After filtration the mixture was concentrated and purified by Biotage (SNAP silica 340 g, EtOAc:Hexane) to give the title compound (6.07 g, 51%).

228-1: (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (4RS)-4({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-methyl-6-oxo-N-phenyl-2-[(pyridin-4-ylmethypamino]cyclohex-1-ene-1-carbothioamide (228-2; 27.9 g, 43.9 mmol), hydrogen peroxide (30% in water, 17.9 mL, 176 mmol) in MeOH (836 mL) was heated at 50° C. for 16 h. The mixture was concentrated and purified by Biotage (SNAP silica 340 g, EtOAc:Hexane) to give the title compound (18.6 g, 71%).

(6RS)-2-(2-Aminopyridin-4-yl)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-anilino-6({[tert-butyl(diphenyl)silyl]oxy}methyl)-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one (228-1; 1.5 g, 2.5 mmol) and TBAF (6.2 mL, 1M in THF) in THF (35 mL) was stirred at 50° C. for 16 h. EtOAc (100 mL) was added, the mixture washed with sodium hydroxide (2.5% in water), brine and dried over sodium sulfate. After filtration and removal of the solvent the residue was purified by Biotage (SNAP silica 340 g, MeOH:DCM) to give the title compound (540 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.98 (3H), 2.06 (1H), 2.37 (1H), 2.56 (1H), 2.93 (1H), 3.24 (1H), 3.29 (1H), 4.85 (1H), 5.73 (2H), 6.56 (2H), 6.60 (1H), 6.61 (1H), 6.71 (1H), 7.03 (2H), 7.22 (1H), 7.77 (1H), 11.65 (1H)

Example 229 N-4-[(6RS)-6-[(2-Methoxyethyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium 2-methoxyethanethiolate (110 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (54 mg, 72%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.08 (3H), 2.28 (1H), 2.40 (1H), 2.45 (1H), 2.62-2.73 (5H), 3.14 (1H), 3.26 (3H), 3.50 (2H), 6.57 (2H), 6.61 (1H), 7.02 (2H), 7.16 (1H), 7.34 (1H), 8.09 (1H), 8.23 (1H), 10.32 (1H), 11.94 (1H)

Example 230 N-4-[(6RS)-6-[(1,3—Oxazol-2-ylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium 1,3-oxazole-2-thiolate (118 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (54 mg, 68%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.08 (3H), 2.37 (1H), 2.45 (1H), 2.59 (1H), 2.74 (1H), 3.13 (1H), 3.29-3.41 (2H), 6.56 (2H), 6.61 (1H), 7.02 (2H), 7.16 (1H), 7.27 (1H), 7.33 (1H), 8.09 (1H), 8.17 (1H), 8.23 (1H), 10.32 (1H), 11.96 (1H)

Example 231 N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(1,3-thiazol-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium 1,3-thiazole-2-thiolate (134 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (53 mg, 64%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.08 (3H), 2.39 (1H), 2.47 (1H), 2.60 (1H), 2.77 (1H), 3.15 (1H), 3.42 (2H), 6.57 (2H), 6.61 (1H), 7.02 (2H), 7.16 (1H), 7.33 (1H), 7.68 (1H), 7.75 (1H), 8.09 (1H), 8.23 (1H), 10.32 (1H), 11.95 (1H)

Example 232 N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(pyridin-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium pyridine-2-thiolate (128 mg, 960 μmol) in DMA (3 mL) was stirred at 1000 for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (54 mg, 66%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.36 (1H), 2.47 (1H), 2.50 (1H), 2.73 (1H), 3.12 (1H), 3.28-3.40 (2H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.09-7.18 (2H), 7.32 (1H), 7.36 (1H), 7.65 (1H), 8.06 (1H), 8.23 (1H), 8.44 (1H), 10.29 (1H), 11.92 (1H)

Example 233 N-4-[(6RS)-6-[(4-Fluorobenzyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium (4-fluorophenyl)methanethiolate (158 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (64 mg, 74%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.08 (3H), 2.23 (1H), 2.36-2.44 (2H), 2.56 (1H), 2.63 (1H), 3.09 (1H), 3.35 (1H), 3.78 (2H), 6.57 (2H), 6.61 (1H), 7.02 (2H), 7.12-7.17 (3H), 7.33 (1H), 7.38 (2H), 8.06 (1H), 8.25 (1H), 10.29 (1H), 11.93 (1H)

Example 234 (15,25)-2-Fluoro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)cyclopropanecarboxamide

A solution of (1S,2S)-2-fluorocyclopropanecarboxylic acid (26 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (24 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.16 (1H), 1.20 (6H), 1.62 (1H), 2.18 (1H), 2.27 (1H), 2.34 (1H), 2.43 (1H), 2.58-2.70 (3H), 2.93 (1H), 3.12 (1H), 4.90 (1H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.35 (1H), 8.07 (1H), 8.24 (1H), 10.70 (1H), 11.97 (1H)

Example 235 N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)-1,3-thiazole-5-carboxamide

A solution of 1,3-thiazole-5-carboxylic acid (32 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (30 mg, 45%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.21 (6H), 2.29 (1H), 2.36 (1H), 2.44 (1H), 2.60-2.71 (3H), 2.93 (1H), 3.13 (1H), 6.57 (2H), 6.60 (1H), 7.01 (2H), 7.24 (1H), 7.40 (1H), 8.18 (1H), 8.28 (1H), 8.86 (1H), 9.31 (1H), 11.08 (1H), 12.00 (1H)

Example 236 4-Fluoro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide

A solution of 4-fluorobenzoic acid (34 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (24 mg, 34%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.21 (6H), 2.29 (1H), 2.37 (1H), 2.45 (1H), 2.60-2.71 (3H), 2.94 (1H), 3.13 (1H), 6.57 (2H), 6.59 (1H), 7.01 (2H), 7.23 (1H), 7.34 (2H), 7.39 (1H), 8.08(2H), 8.16 (1H), 8.32 (1H), 10.72 (1H), 11.99 (1H)

Example 237 4-Chloro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide

A solution of 4-chlorobenzoic acid (39 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (26 mg, 37%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.21 (6H), 2.29 (1H), 2.36 (1H), 2.44 (1H), 2.60-2.71 (3H), 2.94 (1H), 3.13 (1H), 6.57 (2H), 6.59 (1H), 7.01 (2H), 7.23 (1H), 7.40 (1H), 7.58 (2H), 8.02 (2H), 8.16 (1H), 8.32 (1H), 10.78 (1H), 12.00 (1H)

Example 238 3,4-Dichloro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide

A solution of 3,4-dichlorobenzoic acid (39 mg, 246 μmol) and HATU (94 mg, 246 μmol) in DMA (1.2 mL) was added to a mixture of (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (192; 50 mg, 123 μmol) and DIPEA (43 μL, 246 μmol) in DMA (1.2 mL) and the reaction was stirred at 50° C. for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (26 mg, 37%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.21 (6H), 2.29 (1H), 2.37 (1H), 2.44 (1H), 2.59-2.71 (3H), 2.94 (1H), 3.13 (1H), 6.57 (2H), 6.60 (1H), 7.01 (2H), 7.24 (1H), 7.40 (1H), 7.79 (1H), 7.96 (1H), 8.18 (1H), 8.25 (1H), 8.31 (1H), 10.91 (1H), 12.00 (1H)

Example 239 N-4-[(6RS)-6-[(Ethylsulfonyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture comprising N-4-[(6RS)-6-[(ethylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (189; 37 mg, 85 μmol), mCPBA (36 mg, 75%) and DMA (2.5 mL) was stirred at RT. After 16 h a second portion mCPBA (9 mg, 75%) was added. The mixture was stirred at RT for 4 h, DMSO (750 μL) was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (23 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.25 (3H), 2.08 (3H), 2.41 (1H), 2.48-2.57 (2H), 2.81-2.89 (2H), 3.16 (2H), 3.25-3.31 (2H), 6.58 (2H), 6.62 (1H), 7.03 (2H), 7.18 (1H), 7.35 (1H), 8.09 (1H), 8.24 (1H), 10.32 (1H), 12.01 (1H)

Example 240 N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide

A mixture comprising N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-ypacetamide (190; 36 mg, 80 μmol), mCPBA (34 mg, 75%) and DMA (2.5 mL) was stirred at RT. After 16 h a second portion mCPBA (8 mg, 75%) was added. The mixture was stirred at RT for 4 h, DMSO (750 μL) was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (23 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.25 (6H), 2.05 (3H), 2.39 (1H), 2.51 (1H), 2.77-2.86 (2H), 3.23-3.31 (4H), 6.55 (2H), 6.59 (1H), 7.00 (2H), 7.15 (1H), 7.34 (1H), 8.07 (1H), 8.22 (1H), 10.33 (1H), 12.01 (1H)

Example 241 2-Fluoro-2-methyl-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)propanamide

A mixture comprising N-(4-{(6RS)-3-anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl}pyridin-2-yl)-2-fluoro-2-methylpropanamide (213; 28 mg, 57 μmol), mCPBA (30 mg, 75%) and DMA (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (18 mg, 58%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.28 (6H), 1.57 (3H), 1.61 (3H), 2.44 (1H), 2.49-2.57 (2H), 2.81-2.90 (2H), 3.26-3.38 (3H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.27 (1H), 7.41 (1H), 8.15 (1H), 8.17 (1H), 9.68 (1H), 12.07 (1H)

Example 242 4-Fluoro-3-methoxy-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide

A mixture comprising N-(4-{(6RS)-3-anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl}pyridin-2-yl)-4-fluoro-3-methoxybenzamide (212; 32 mg, 57 μmol), mCPBA (30 mg, 75%) and DMA (2 mL) was stirred at RT for 16 h. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (16 mg, 44%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.28 (6H), 2.44 (1H), 2.48-2.58 (2H), 2.81-2.92 (2H), 3.27-3.35 (3H), 3.96 (3H), 6.61 (2H), 6.63 (1H), 7.04 (2H), 7.27 (1H), 7.37 (1H), 7.41 (1H), 7.66 (1H), 7.86 (1H), 8.20 (1H), 8.37 (1H), 10.76 (1H), 12.09 (1H)

Example 243 N-4-[(6RS)-6-[(tert-Butylsulfonyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture comprising N-4-[(6RS)-6-[(tert-butylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (191; 39 mg, 84 μmol), mCPBA (36 mg, 75%) and DMA (2.5 mL) was stirred at RT. After 16 h a second portion mCPBA (9 mg, 75%) was added. The mixture was stirred at RT for 4 h, DMSO (750 μL) was added, the mixture concentrated and purified by preparative HPLC (basic method) to give the title compound (25 mg, 57%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.35 (9H), 2.08 (3H), 2.44 (1H), 2.56 (1H), 2.78-2.91 (2H), 3.24-3.39 (3H), 6.57 (2H), 6.61 (1H), 7.03 (2H), 7.18 (1H), 7.35 (1H), 8.09 (1H), 8.24 (1H), 10.32 (1H), 12.02 (1H)

Example 244 (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,N,6-trimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide 244-2: Methyl (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A solution of 2-fluoro-2-methylpropanoic acid (340 μL, 3.59 mmol) and HATU (1.36 g, 3.59 mmol) in DMA (13 mL) was added to a mixture of methyl (6RS)-2-(2-aminopyridin-4-yl)-3-anilino-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (141-2; 700 mg, 1.79 mmol) and DIPEA (625 μL, 3.59 mmol) in DMA (13 mL) and the reaction was stirred at RT for 16 h. The mixture was concentrated, EtOAc was added, the mixture washed with water, brine and dried over sodium sulfate. After filtration and removal of the solvent, the mixture was purified Biotage (SNAP NH 28 g, EtOAc:Hexane) to give the title compound (603 mg, 67%).

244-1: (6RS)-3-Anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid

A mixture of methyl (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate (244-2; 1.600 mg, 1.25 mmol), lithium hydroxide (7.5 mL, 1M in water), THF (22 mL) and MeOH (7 mL) was stirred at RT for 16 h. Citric acid (506 mg) in water (10 mL) was added and the mixture concentrated. The precipitate was washed with water and dried to give the title compound (304 mg, 50%).

(6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,N,6-trimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of N-methylmethanamine (139 μL, 2M in THF) and DIPEA (48 μL, 277 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (19 mg, 40%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.39 (3H), 1.54 (3H), 1.59 (3H), 2.44 (1H), 2.77 (1H), 2.90 (1H), 2.93 (6H), 3.49 (1H), 6.52 (2H), 6.59 (1H), 6.99 (2H), 7.20 (1H), 7.40 (1H), 8.11 (1H), 8.12 (1H), 9.70 (1H), 11.90 (1H)

Example 245 (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-phenylamino)-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of N-methylpropan-1-amine (28 μL, 277 μmol) and DIPEA (48 μL, 277 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (19 mg, 37%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.70 (3H), 1.39 (2H), 1.43 (3H), 1.57 (3H), 1.61 (3H), 2.45 (1H), 2.78 (1H), 2.94 (2H), 3.01 (3H), 3.13 (1H), 3.52 (1H), 6.55 (2H), 6.61 (1H), 7.01 (2H), 7.22 (1H), 7.38 (1H), 8.11-8.16 (2H), 9.68 (1H), 11.89 (1H)

Example 246 (6RS)-N,N-Diethyl-2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of N-ethylethanaminium chloride (30 mg, 277 μmol) and DIPEA (97 μL, 554 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (21 mg, 41%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.03 (6H), 1.41 (3H), 1.57 (3H), 1.61 (3H), 2.47 (1H), 2.75 (1H), 2.93 (1H), 3.18-3.43 (4H), 3.44 (1H), 6.55 (2H), 6.61 (1H), 7.01 (2H), 7.23 (1H), 7.38 (1H), 8.11-8.16 (2H), 9.67 (1H), 11.91 (1H)

Example 247 (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of N,2-dimethylpropan-1-amine (33 μL, 277 μmol) and DIPEA (48 μL, 277 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (18 mg, 35%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.57 (3H), 0.68 (3H), 1.43 (3H), 1.57 (3H), 1.61 (3H), 1.74 (1H), 2.41 (1H), 2.79 (1H), 2.84 (1H), 2.95 (1H), 3.11 (3H), 3.26 (1H), 3.57 (1H), 6.55 (2H), 6.62 (1H), 7.01 (2H), 7.20 (1H), 7.35 (1H), 8.10-8.15 (2H), 9.67 (1H), 11.88 (1H)

Example 248 (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of 3,3,3-trifluoro-N-methylpropan-1-aminium chloride (45 mg, 277 μmol) and DIPEA (97 μL, 554 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (24 mg, 43%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.41 (3H), 1.57 (3H), 1.61 (3H), 2.35 (2H), 2.47 (1H), 2.77 (1H), 2.96 (1H), 3.15 (3H), 3.36 (1H), 3.52 (2H), 6.55 (2H), 6.61 (1H), 7.01 (2H), 7.23 (1H), 7.37 (1H), 8.11-8.17 (2H), 9.68 (1H), 11.91 (1H)

Example 249 (6RS)-N-(Cyclopropylmethyl)-2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of cyclopropyl-N-methylmethanaminium chloride (34 mg, 277 μmol) and DIPEA (97 μL, 554 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (10 mg, 19%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 0.06 (1H), 0.14 (1H), 0.31 (1H), 0.37 (1H), 0.83 (1H), 1.43 (3H), 1.57 (3H), 1.61 (3H), 2.45 (1H), 2.80 (1H), 2.95 (1H), 3.07 (1H), 3.09 (3H), 3.27 (1H), 3.54 (1H), 6.55 (2H), 6.61 (1H), 7.01 (2H), 7.22 (1H), 7.39 (1H), 8.10-8.15 (2H), 9.68 (1H), 11.90 (1H)

Example 250 2-Fluoro-2-methyl-N-4-[(6RS)-6-methyl-4-oxo-3-(phenylamino)-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylpropanamide

A solution of (6RS)-3-anilino-2-{2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (244-1; 43 mg, 92 μmol) and HATU (70 mg, 185 μmol) in DMA (1 mL) was added to a mixture of pyrrolidine (23 μL, 277 μmol) and DIPEA (48 μL, 277 μmol) in DMA (1 mL) and the reaction was stirred at RT for 1 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (20 mg, 41%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.36 (3H), 1.58 (3H), 1.61 (3H), 1.79 (4H), 2.49 (1H), 2.83 (1H), 2.88 (1H), 3.14-3.79 (5H), 6.55 (2H), 6.61 (1H), 7.02 (2H), 7.24 (1H), 7.42 (1H), 8.10-8.17 (2H), 9.68 (1H), 11.92 (1H)

Example 251 N-{4-[(6RS)-3-Anilino-6-{[(4-fluorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture of [(6RS)-2-(2-acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol) and sodium 4-fluorobenzenethiolate (156 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. Water was added, the mixture concentrated and purified by preparative HPLC (basic method) and preparative TLC (MeOH:DCM) to give the title compound (40 mg, 47%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.30-2.39 (2H), 2.46 (1H), 2.71 (1H), 3.06-3.18 (3H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.14 (1H), 7.18 (2H), 7.33 (1H), 7.46 (2H), 8.08 (1H), 8.22 (1H), 10.35 (1H), 11.95 (1H)

Example 252 N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)morpholine-4-carboxamide

A mixture of (6RS)-2-(2-aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one (194; 30 mg, 68 μmol) and morpholine-4-carbonyl chloride (24 μL, 205 μmol) in pyridine (0.8mL) was stirred at RT for 2 days. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (12 mg, 31%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.26 (6H), 2.41 (1H), 2.76-2.89 (2H), 3.14 (1H), 3.23-3.33 (3H), 3.45 (4H), 3.54-3.62 (5H), 6.57 (2H), 6.61 (1H), 7.02 (2H), 7.11 (1H), 7.35 (1H), 7.91 (1H), 8.02 (1H), 9.11 (1H), 11.99 (1H)

Example 253 N-{4-[(6RS)-3-Anilino-6-{[(3,4-dichlorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture of [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol), sodium 3,4-dichlorobenzenethiolate (193 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (59 mg, 66%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.37 (1H), 2.41-2.49 (2H), 2.72 (1H), 3.13 (1H), 3.18 (1H), 3.26 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.34 (1H), 7.38 (1H), 7.56 (1H), 7.65 (1H), 8.08 (1H), 8.22 (1H), 10.35 (1H), 11.95 (1H)

Example 254 N-{4-[(6RS)-3-Anilino-6-{[(4-chlorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamicle

A mixture of [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol), sodium 4-chlorobenzenethiolate (160 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (50 mg, 60%).

¹H NMR (400 MHz, DMSO-d6) δ ppm 2.07 (3H), 2.32-2.48 (3H), 2.72 (1H), 3.09-3.17 (2H), 3.20 (1H), 6.54 (2H), 6.59 (1H), 7.01 (2H), 7.15 (1H), 7.32-7.43 (5H), 8.08 (1H), 8.22 (1H), 10.34 (1H), 11.95 (1H)

Example 255 N-4-[(6RS)-6-[(4-Fluoro-3-methoxyphenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol), sodium 4-fluoro-3-methoxybenzenethiolate (173 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (34 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.29-2.48 (3H), 2.70 (1H), 3.05 (1H), 3.09-3.16 (2H), 3.81 (3H), 6.54 (2H), 6.59 (1H), 7.00 (2H), 7.10-7.16 (2H), 7.20 (1H), 7.33 (1H), 7.35 (1H), 8.08 (1H), 8.22 (1H), 10.35 (1H), 11.94 (1H)

Example 256 N-4-[(6RS)-6-[(3,4-Difluorophenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol), sodium 3,4-difluorobenzenethiolate (161 mg, 960 μmol) in DMA (3 mL) was stirred at 1001 for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (41 mg, 46%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.31-2.47 (3H), 2.71 (1H), 3.10-3.17 (2H), 3.21 (1H), 6.55 (2H), 6.60 (1H), 7.01 (2H), 7.15 (1H), 7.23 (1H), 7.34 (1H), 7.40 (1H), 7.55 (1H), 8.08 (1H), 8.22 (1H), 10.35 (1H), 11.94 (1H)

Example 257 N-4-[(6RS)-6-[(4-Metehoxyphenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide

A mixture of [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol), sodium 4-methoxybenzenethiolate (156 mg, 960 μmol) in DMA (3 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (54 mg, 60%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.26-2.37 (2H), 2.38-2.47 (1H), 2.70 (1H), 2.98 (1H), 3.06 (1H), 3.13 (1H), 3.73 (3H), 6.54 (2H), 6.59 (1H), 6.92 (2H), 7.00 (2H), 7.14 (1H), 7.33 (1H), 7.38 (2H), 8.08 (1H), 8.22 (1H), 10.35 (1H), 11.94 (1H)

Example 258 Methyl (6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate 258-2: Methyl (1RS)-3-hydroxy-5-oxo-4-(pyridin-2-ylcarbamothioyl)cyclohex-3-ene-1-carboxylate

To a solution of methyl (1RS)-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate (4.96 g, 29.2 mmol; commercially available from FCH Group Company) and 2-isothiocyanatopyridine (3.97 g, 29.2 mmol) in MeCN (100 mL) was added TEA (1.64 mL, 11.7 mmol) and the mixture was stirred at reflux for 16 h. Ethyl acetate was added, the mixture washed with water and brine and dried over sodium sulfate. After filtration and concentration the residue was purified by Biotage (SNAP silica 100 g, EtOAc:Hexane) to give the title compound (1.35 g, 14%).

258-1: Methyl (1RS)-5-oxo-4-(pyridin-2-ylcarbamothioyl)-3-[(pyridin-4-ylmethyl)amino]cyclohex-3-ene-1-carboxylate

A solution of methyl (1RS)-3-hydroxy-5-oxo-4-(pyridin-2-ylcarbamothioyl)cyclohex-3-ene-1-carboxylate (258-2; 1.35 g, 4.41 mmol) and 1-(pyridin-4-yl)methanamine (895 μL, 8.81 mmol) in DMA (5 mL) was heated at 120° C. for 1.5 h. The mixtu re was concentrated and purified by Biotage (SNAP silica 100 g, MeOH:DCM) to give the title compound (280 mg, 14%).

Methyl (6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate

A mixture of methyl (1RS)-3-hydroxy-5-oxo-4-(pyridin-2-ylcarbamothioyl)cyclohex-3-ene-1-carboxylate (258-1; 275 mg, 693 μmol), hydrogen peroxide (34% in water, 121 μL, 1.39 mmol) in MeOH (25 mL) was heated at 90° C. for 24 h. The mixtu re was concentrated and purified by Biotage (SNAP silica 50 g, MeOH:DCM) to give the title compound (35 mg, 14%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.57 (2H), 3.12 (1H), 3.18 (1H), 3.37 (1H), 3.64 (3H), 6.37 (1H), 6.58 (1H), 7.38 (1H), 7.52 (2H), 7.94 (1H), 8.02 (1H), 8.45 (2H), 12.01 (1H)

Example 259 (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6-[(isopropylsulfanyl)methyl]-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one 259-1: [(6RS)-3-Anilino-6-methyl-2-{2-[(methylsulfonyl)amino]pyridin-4-yl}-4-oxo-4,5,6,7-tetrahydro-1 H-indol-6-yl]methyl methanesulfonate

A solution of (6RS)-2-(2-aminopyridin-4-yl)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one (228; 6.70 g, 18.5 mmol), DMAP (452 mg, 3.70 mmol) and methanesulfonyl chloride (2.15 mL, 27.7 mmol) in pyridine (100 mL) was stirred at RT for 4 h. MeOH was added, the mixture concentrated and purified by Biotage (SNAP silica 340 g, MeOH:DCM) and by crystallization from MeOH to give the title compound (873 mg, 9%).

(6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6-[(isopropylsulfanyl)methyl]-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one

A mixture of [(6RS)-3-anilino-6-methyl-2-{2-[(methylsulfonyl)amino]pyridin-4-yl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (259-1; 100 mg, 227 μmol), sodium propane-2-thiolate (134 mg, 1.36 mmol) in DMA (3.2 mL) was stirred at 100° C. for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (8 mg, 8%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 1.07 (3H), 1.17 (6H), 2.24 (1H), 2.39 (1H), 2.66 (2H), 2.74 (1H), 2.83 (1H), 2.95 (1H), 5.73 (2H), 6.52-6.61 (4H), 6.70 (1H), 7.01 (2H), 7.23 (1H), 7.76 (1H), 11.70 (1H)

Example 260 N-(4-{(6RS)-3-Anilino-4-oxo-6-[(1,3-thiazol-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide

A mixture comprising N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(1,3-thiazol-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-ypacetamide (231; 45 mg, 92 μmol), mCPBA (48 mg, 75%) and DMA (2.5 mL) was stirred at RT for 16 h, DMSO was added, the mixture filtered and purified by preparative HPLC (basic method) to give the title compound (6 mg, 14%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.23 (3H), 2.44 (2H), 2.77 (1H), 2.87 (1H), 3.25 (1H), 3.81 (1H), 3.89 (1H), 6.57 (2H), 6.61 (1H), 7.03 (2H), 7.20 (1H), 7.36 (1H), 8.19-8.25 (2H), 8.35 (1H), 8.48 (1H), 10.41 (1H), 12.08 (1H)

Example 261 N-{4-[(6RS)-3-Anilino-6-{[(4-fluoro-3-hydroxyphenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1 H-indol-2-yl]pyridin-2-yl}acetamide

A mixture of [(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl methanesulfonate (151-1; 75 mg, 160 μmol), sodium 4-fluoro-3-methoxybenzenethiolate (173 mg, 960 μmol) in DMA (3 mL) was stirred at 1001 for 5 h. The mixture was concentrated and purified by preparative TLC (MeOH:DCM) to give the title compound (34 mg, 38%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.27-2.37 (2H), 2.44 (1H), 2.69 (1H), 3.00 (1H), 3.07 (1H), 3.12 (1H), 6.54 (2H), 6.59 (1H), 6.91 (1H), 7.00 (2H), 7.07 (1H), 7.15 (1H), 7.26 (1H), 7.33 (1H), 8.08 (1H), 8.22 (1H), 10.04 (1H), 10.34 (1H), 11.94 (1H)

Example 262 N-{4-[(6RS)-3-Anilino-6-{[(2-methoxyethyl)sulfonyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture comprising N-4-[(6RS)-6-[(2-methoxyethyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (229; 46 mg, 99 μmol), mCPBA (52 mg, 75%) and DMA (2.5 mL) was stirred at RT for 16 h, DMSO was added, the mixture filtered and purified by preparative HPLC (basic method) to give the title compound (7 mg, 13%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.39 (1H), 2.47 (1H), 2.79-2.90 (1H), 3.20-3.35 (4H), 3.28 (3H), 3.44 (2H), 3.71 (2H), 6.56 (2H), 6.60 (1H), 7.02 (2H), 7.17 (1H), 7.36 (1H), 8.08 (1H), 8.24 (1H), 10.35 (1H), 12.02 (1H)

Example 263 N-{4-[(6RS)-3-Anilino-6-{[(4-fluorobenzy0sulfonyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide

A mixture comprising N-4-[(6RS)-6-[(4-fluorobenzyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide (233; 55 mg, 107 μmol), mCPBA (56 mg, 75%) and DMA (2.5 mL) was stirred at RT 16 h, DMSO was added, the mixture filtered and purified by preparative HPLC (basic method) to give the title compound (8 mg, 14%).

¹H NMR (400 MHz, DMSO-d₆) δ ppm 2.07 (3H), 2.38 (1H), 2.47 (1H), 2.79-2.91 (2H), 3.21-3.31 (3H), 4.57 (2H), 6.56 (2H), 6.60 (1H), 7.02 (2H), 7.17 (1H), 7.26 (2H), 7.36 (1H), 7.46 (2H), 8.09 (1H), 8.24 (1H), 10.35 (1H), 12.03 (1H)

The compounds of examples 264 to 311 have been prepared according to the general procedures outlined in schemes 1 to 19 and in analogy to the experiments described for examples 1 to 263:

Structure IUPAC-Name Mass found (M + 1) Example ¹H-NMR 264

(6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H- indole-6-carboxylic acid MS (ES+): m/z = 349 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.53-2.56 (2H), 3.10 (2H), 3.38-3.52 (1H), 6.36 (1H), 6.58 (1H), 7.37 (1H), 7.51 (2H), 7.94 (1H), 8.00 (1H), 8.44 (2H), 11.96 (1H) 265

tert-butyl (6RS)-4-oxo-3-(phenylamino)-2-pyridin-4-yl)-4,5,6,7-tetrahydro-1H- indole-6-carboxylate MS (ES+): m/z = 404 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.37 (9H), 2.52-2.61 (2H), 3.08-3.18 (2H), 3.22 (1H), 6.57 (2H), 6.62 (1H), 7.03 (2H), 7.43-7.48 (3H), 8.42 (2H), 12.00 (1H) 266

(6RS)-N,N-dimethyl-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7- tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 376 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.31 (1H), 2.47 (1H), 2.85 (3H), 2.92- 3.04 (2H), 3.07 (3H), 3.64 (1H), 6.38 (1H), 6.59 (1H), 7.38 (1H), 7.52 (2H), 7.96 (1H), 7.99 (1H), 8.45 (2H), 11.97 (1H) 267

(6RS)-N-[(2S)-2-hydroxypropyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin- 4-yl)-4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 419 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.00 + 1.06 (3H), 2.24-2.40 (1H), 2.44- 2.59 (1H), 2.87 + 3.11 (3H), 2.91-3.21 (3H), 3.27-3.47 (1H), 3.60-3.87 (2H), 4.68 + 4.90 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.42-7.48 (3H), 8.41 (2H), 11.93 + 11.95 (1H) 268

(6RS)-N-[(2R)-2-hydroxypropyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin- 4-yl)-4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 419 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.00 + 1.06 (3H), 2.25-2.39 (1H), 2.45- 2.59 (1H), 2.87 + 3.11 (3H), 2.92-3.20 (3H), 3.27-3.47 (1H), 3.60-3.86 (2H), 4.68 + 4.90 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43-7.48 (3H), 8.41 (2H), 11.95 (1H) 269

(6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-[2-(pyrrolidin-1- yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 458 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.61-1.71 (4H), 2.29-2.36 (1H), 2.41- 2.55 (6H), 2.58 (1H), 2.86 + 3.07 (3H), 2.89-3.06 (2H), 3.38-3.58 (2H), 3.64 (1H), 6.59 (2H), 6.63 (1H), 7.04 (2H), 7.43-7.47 (3H), 8.41 (2H), 11.95 (1H) 270

(6RS)-N-methyl-N-[2-(morpholin-4-yl)ethyl]-4-oxo-3-(phenylamino)-2- (pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 474 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.29-2.59 (8H), 2.87 + 3.07 (3H), 2.91- 3.05 (2H), 3.40-3.58 (6H), 3.65 (1H), 6.59 (2H), 6.64 (1H), 7.05 (2H), 7.43-7.48 (3H), 8.41 (2H), 11.95 (1H) 271

(6RS)-N-cyclobutyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7- tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 415 1H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.55-1.67 (2H), 1.95-2.36 (5H), 2.41- 2.57 (1H), 2.84 + 3.00 (3H), 2.91-3.06 (2H), 3.60 + 3.72 (1H), 4.62 + 4.84 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.43 (1H), 7.46 (2H), 8.41 (2H), 11.95 (1H) 274

(6RS)-N-[(2S)-1-methoxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2- (pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 433 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.00 + 1.10 (3H), 2.22-2.39 (1H), 2.54- 2.60 (1H), 2.69 + 2.90 (3H), 2.91-3.08 (2H), 3.22 + 3.25 + 3.30 (3H), 3.24-3.31 (1H), 3.39 (1H), 3.64 (1H), 4.28 + 4.73 (1H), 6.60 (2H), 6.64 (1H), 7.05 (2H), 7.42-7.48 (3H), 8.41 (2H), 11.94 (1H) 275

(6RS)-N-(1-methoxy-2-methylpropan-2-yl)-N-methyl-4-oxo-3-(phenylamino)- 2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 447 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.31 (6H), 2.29 + 2.33 (1H), 2.39-2.47 (1H), 2.91-3.03 (2H), 2.97 (3H), 3.20 (3H), 3.49 (1H), 3.58 (1H), 3.66 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43 (1H), 7.44 (2H), 8.40 (2H), 11.91 (1H) 276

(−) methyl (6R or 6S)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1H-indole-6-carboxylate MS (ES+): m/z = 380.1 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.54-2.66 (2H), 3.11 (1H), 3.18 (1H), 3.36 (1H), 3.64 (3H), 6.54 (2H), 6.59 (1H), 6.98 (2H), 7.39 (1H), 7.54 (1H), 8.25 (1H), 8.50 (1H), 11.73 (1H) 277

(+) methyl (6S or 6R)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1H-indole-6-carboxylate MS (ES+): m/z = 380.1 ¹H-NMR(400 MHz, DMSO-d6), δ [ppm] = 2.54-2.66 (2H), 3.11 (1H), 3.18 (1H), 3.36 (1H), 3.64 (3H), 6.54 (2H), 6.59 (1H), 6.98 (2H), 7.39 (1H), 7.54 (1H), 8.25 (1H), 8.50 (1H), 11.73 (1H) 278

(+)-(6S or 6R)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1H-indole-6-carboxylic acid MS (ES+): m/z = 366.1 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.53-2.63 (2H), 3.06-3.19 (2H), 3.24 (1H), 6.55 (2H), 6.59 (1H), 6.98 (2H), 7.39 (1H), 7.54 (1H), 8.24 (1H), 8.50 (1H), 11.70 (1H), 12.59 (1H) 279

(−)-(6R or 6S)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1H-indole-6-carboxylic acid MS (ES+): m/z = 366.1 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.53-2.63 (2H), 3.06-3.19 (2H), 3.24 (1H), 6.55 (2H), 6.59 (1H), 6.98 (2H), 7.39 (1H), 7.54 (1H), 8.24 (1H), 8.50 (1H), 11.70 (1H), 12.59 (1H) 280

(+)-(6S or 6R)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)- 4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 393.2 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.34 (1H), 2.50 (1H), 2.85 (3H), 2.94- 3.03 (2H), 3.06 (3H), 3.66 (1H), 6.57 (2H), 6.59 (1H), 6.99 (2H), 7.39 (1H), 7.53 (1H), 8.24 (1H), 8.49 (1H), 11.66 (1H) 281

(−)-(6R or 6S)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)- 4,5,6,7-tetrahydro-1H-indole-6-carboxamide MS (ES+): m/z = 393.2 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.34 (1H), 2.50 (1H), 2.85 (3H), 2.94- 3.03 (2H), 3.06 (3H), 3.66 (1H), 6.57 (2H), 6.59 (1H), 6.99 (2H), 7.39 (1H), 7.53 (1H), 8.24 (1H), 8.49 (1H), 11.66 (1H) 282

(6RS)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7- tetrahydro-4H-indol-4-one MS (ES+): m/z = 362 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.14 (3H), 1.16 (3H), 2.15 (1H), 2.25- 2.39 (2H), 2.71 (1H), 2.97 (1H), 4.44 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.42 (1H), 7.47 (2H), 8.41 (2H), 11.90 (1H) 283

(6R or 6S)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7 tetrahydro-4H-indol-4-one MS (ES+): m/z = 362 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.14 (3H), 1.16 (3H), 2.15 (1H), 2.25- 2.39 (2H), 2.71 (1H), 2.97 (1H), 4.44 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.42 (1H), 7.47 (2H), 8.41 (2H), 11.90 (1H) 284

(6S or 6R)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7 tetrahydro-4H-indol-4-one MS (ES+): m/z = 362 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.14 (3H), 1.16 (3H), 2.15 (1H), 2.25- 2.39 (2H), 2.71 (1H), 2.97 (1H), 4.44 (1H), 6.57 (2H), 6.63 (1H), 7.04 (2H), 7.42 (1H), 7.47 (2H), 8.41 (2H), 11.90 (1H) 285

N-{4-[(6RS)-6-(2-hydroxypropan-2-yl)-4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide MS (ES+): m/z = 419.2 1H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.14 (3H), 1.15 (3H), 2.07 (3H), 2.13 (1H), 2.24-2.38 (2H), 2.67 (1H), 2.99 (1H), 4.42 (1H), 6.56 (2H), 6.60 (1H), 7.01 (2H), 7.16 (1H), 7.34 (1H), 8.08 (1H), 8.23 (1H), 10.34 (1H), 11.91 (1H) 286

N-{4-[(6RS)-6-(2-hydroxypropan-2-yl)-6-methyl-4-oxo-3-(phenylamino)- 4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide MS (ES+): m/z = 433 ¹H-NMR (400 MHz, DICHLOROMETHANE-d2), δ [ppm] = 1.12 (3H), 1.32 (6H), 2.22 (3H), 2.29 (1H), 2.68 (1H), 2.84 (1H), 3.32 (1H), 6.72 (2H), 6.79 (1H), 7.00 (1H), 7.08-7.18 (3H), 7.97 (1H), 8.21 (1H), 8.37 (1H), 9.73 (1H) 287

(6RS)-2-(3-fluoropyridin-4-yl)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)- 1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 380.2 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.14 (3H), 1.15 (3H), 2.14 (1H), 2.25- 2.40 (2H), 2.66 (1H), 2.99 (1H), 4.43 (1H), 6.54 (2H), 6.59 (1H), 6.98 (2H), 7.39 (1H), 7.50 (1H), 8.24 (1H), 8.49 (1H), 11.61 (1H) 288

(6RS)-3-(phenylamino)-6-(prop-2-en-1-yl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro- 4H-indol-4-one MS (ES+): m/z = 344.3 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.17-2.37 (5H), 2.59 (1H), 2.95 (1 H), 5.07 (1H), 5.10 (1H), 5.84 (1H), 6.57 (2H), 6.62 (1H), 7.03 (2H), 7.42-7.47 (3H), 8.40 (2H), 11.89 (1H) 290

(6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-3-(phenylamino)-6-(prop-2-en-1- yl)-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 418 ¹H-NMR (400MHz, DMSO-d6), δ [ppm] = 2.15-2.37 (5H), 2.58 (1H), 2.93 (1H), 3.38 (3H), 3.75 (2H), 4.28 (2H), 5.07 (1H), 5.10 (1H), 5.84 (1H), 6.53 (2H), 6.58 (1H), 6.98 (2H), 7.30 (1H), 7.39 (1H), 8.03 (1H), 8.38 (1H), 11.15 (1H) 291

(6RS)-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-3-(phenylamino)-6-(prop-2-en- 1-yl)-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 414 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 0.33 (2H), 0.55 (2H), 1.128 (1H), 2.17- 2.36 (5H), 2.56 (1H), 2.95 (1H), 3.93 (2H), 5.07 (1H), 5.10 (1H), 5.84 (1H), 6.51 (2H), 6.56 (1H), 6.96 (2H), 7.26 (1H), 7.35 (1H), 8.02 (1H), 8.31 (1H), 11.24 (1H) 294

(6RS)-3-[(3-fluorophenyl)amino]-6-(hydroxymethyl)-2-[3-(2- methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 426.2 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.23 (1H), 2.28-2.36 (2H), 2.66 (1H), 2.94 (1H), 3.37 (3H), 3.44 (2H), 3.72 (2H), 4.29 (2H), 4.74 (1H), 6.20 (1H), 6.32 (1H), 6.37 (1H), 6.99 (1H), 7.33 (1H), 7.58 (1H), 8.09 (1H), 8.41 (1H), 11.27 (1H) 296

(6RS)-6-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-3-(phenylamino)-2- (pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 418.3 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.12-2.46 (18H), 2.60 (1H), 3.01 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.42-7.48 (3H), 8.40 (2H), 11.89 (1H) 297

(6RS)-6-{[4-(dimethylamino)piperidin-1-yl]methyl}-3-(phenylamino)-2- (pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 444.3 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.36 (2H), 1.71 (2H), 1.83 (1H), 1.93 (1H), 2.01 (1H), 2.14-2.28 (2H), 2.16 (6H), 2.28-2.38 (2H), 2.40-2.49 (1H), 2.58 (1H), 2.83 (1H), 2.90 (1H), 3.03 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.42-7.48 (3H), 8.40 (2H), 11.90 (1H) 298

(6RS)-6-[(4-methylpiperazin-1-yl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)- 1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 416.3 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 2.16 (3H), 2.18 (1H), 2.25-2.62 (13H), 3.03 (1H), 6.58 (2H), 6.63 (1H), 7.04 (2H), 7.43-7.47 (3H), 8.40 (2H), 11.91 (1H) 299

4-fluoro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2- ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide MS (ES+): m/z = 545 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.19 (6H), 2.42 (1H), 2.53-2.55 (1H), 2.68-2.91 (5H), 3.20 (1H), 6.58-6.63 (3H), 7.03 (2H), 7.25 (1H), 7.35 (2H), 7.43 (1H), 8.10 (2H), 8.18 (1H), 8.34 (1H), 10.74 (1H), 12.07 (1H) 300

N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}- 4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-1,3-thiazole-5-carboxamide MS (ES+): m/z = 534 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.12-1.25 (6H), 2.42 (1H), 2.53-2.55 (1H), 2.67-2.91 (5H), 3.20 (1H), 6.57-6.64 (3H), 7.03 (2H), 7.27 (1H), 7.43 (1H), 8.20 (1H), 8.30 (1H), 8.88 (1H), 9.33 (1H), 11.11 (1H), 12.07 (1H) 301

(1S,2S)-2-fluoro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2- ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2- yl}cyclopropanecarboxamide MS (ES+): m/z = 509 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.12-1.24 (7H), 1.58-1.69 (1H), 2.20 (1H), 2.41 (1H), 2.46-2.55 (1H), 2.66-2.90 (5H), 3.19 (1H), 4.93 (1H), 6.57 (2H), 6.60 (1H), 7.02 (2H), 7.17 (1H), 7.38 (1H), 8.09 (1H), 8.26 (1H), 10.73 (1H), 12.03 (1H) 302

4-chloro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2- ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide MS (ES+): m/z = 561 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.19 (6H), 2.42 (1H), 2.53-2.56 (1H), 2.68-2.91 (5H), 3.20 (1H), 6.58-6.63 (3H), 7.03 (2H), 7.26 (1H), 7.43 (1H), 7.59 (2H), 8.03 (2H), 8.19 (1H), 8.34 (1H), 10.80 (1H), 12.07 (1H) 303

3,4-dichloro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2- ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide MS (ES+): m/z = 595 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.19 (6H), 2.42 (1H), 2.53-2.56 (1H), 2.67-2.91 (5H), 3.21 (1H), 6.57-6.64 (3H), 7.03 (2H), 7.27 (1H), 7.44 (1H), 7.81 (1H), 7.97 (1H), 8.20 (1H), 8.27 (1H), 8.33 (1H), 10.93 (1H), 12.07 (1H) 304

(6RS)-6-(aminomethyl)-3-[(3-fluorophenyl)amino]-2-[3-(2- methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 425.2 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.68 (2H), 2.11-2.30 (2H), 2.36 (1H), 2.56-2.70 (3H), 2.94 (1H), 3.37 (3H), 3.72 (2H), 4.29 (2H), 6.20 (1H), 6.32 (1H), 6.37 (1H), 6.99 (1H), 7.33 (1H), 7.58 (1H), 8.09 (1H), 8.41 (1H), 11.25 (1H) 305

(6RS)-N-({3-[(3-fluorophenyl)amino]-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4- oxo-4,5,6,7-tetrahydro-1H-indol-6-yl}methyl)acetamide MS (ES+): m/z = 467.5 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.84 (3H), 2.21-2.35 (2H), 2.43-2.55 (1H), 2.60 (1H), 2.90 (1H), 3.07-3.23 (2H), 3.37 (3H), 3.72 (2H), 4.29 (2H), 6.20 (1H), 6.32 (1H), 6.37 (1H), 6.99 (1H), 7.33 (1H), 7.57 (1H), 7.99 (1H), 8.10 (1H), 8.41 (1H), 11.29 (1H) 306

(+)-methyl (6S or 6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6- methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-6-carboxylate MS (ES+): m/z = 409.2 1H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.32 (3H), 2.46 (1H), 2.64 (1H), 2.90 (1H), 3.30 (1H), 3.55 (3H), 5.80 (2H), 6.16 (1H), 6.29-6.37 (2H), 6.58 (1H), 6.69 (1H), 7.01 (1H), 7.57 (1H), 7.80 (1H), 11.81 (1H) 307

(−)-methyl (6R or 6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6- methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-6-carboxylate MS (ES+): m/z = 409.2 1H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.32 (3H), 2.46 (1H), 2.64 (1H), 2.90 (1H), 3.30 (1H), 3.55 (3H), 5.80 (2H), 6.16 (1H), 6.29-6.37 (2H), 6.58 (1H), 6.69 (1H), 7.01 (1H), 7.57 (1H), 7.80 (1H), 11.81 (1H) 308

(6RS)-2-(2-aminopyridin-4-yl)-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1H-indole-6-carboxylic acid MS (ES+): m/z = 377 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.31 (3H), 2.39 (1H), 2.62 (1H), 2.84 (1H), 3.28 (1H), 6.53 (2H), 6.55-6.61 (2H), 6.68 (1H), 7.01 (2H), 7.25 (1H), 7.76 (1H), 11.73 (1H) 309

(6S or 6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo- 4,5,6,7-tetrahydro-1H-indole-6-carboxylic acid hydrochloride MS (ES+): m/z = 395.1 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.32 (3H), 2.43 (1H), 2.63 (1H), 2.90 (1H), 3.34 (1H), 6.32 (1H), 6.36-6.44 (2H), 6.95 (1H), 7.05 (1H), 7.12 (1H), 7.71 (2H), 7.85 (1H), 7.94 (1H), 12.60 (2H), 13.57 (1H) 310

(6R or 6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo- 4,5,6,7-tetrahydro-1H-indole-6-carboxylic acid hydrochloride MS (ES+): m/z = 395.1 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 1.32 (3H), 2.43 (1H), 2.63 (1H), 2.90 (1H), 3.34 (1H), 6.32 (1H), 6.36-6.44 (2H), 6.95 (1H), 7.05 (1H), 7.12 (1H), 7.71 (2H), 7.85 (1H), 7.94 (1H), 12.60 (2H), 13.57 (1H) 311

(6RS)-3-[(3-fluorophenyl)amino]-6-(hydroxymethyl)-2-[3-(2- methoxyethoxy)pyridin-4-yl]-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one MS (ES+): m/z = 440.2 ¹H-NMR (400 MHz, DMSO-d6), δ [ppm] = 0.98 (3H), 2.07 (1H), 2.39 (1H), 2.57 (1H), 2.95 (1H), 3.20-3.32 (2H), 3.37 (3H), 3.73 (2H), 4.29 (2H), 4.87 (1H), 6.19 (1H), 6.32 (1H), 6.37 (1H), 7.00 (1H), 7.35 (1H), 7.58 (1H), 8.09 (1H), 8.41 (1H), 11.23 (1H)

Biological Investigations

The following assays can be used to illustrate the commercial utility of the compounds according to the present invention.

Examples were tested in selected biological assays one or more times. When tested more than once, data are reported as either average values or as median values, wherein

-   -   the average value, also referred to as the arithmetic mean         value, represents the sum of the values obtained divided by the         number of times tested and     -   the median value represents the middle number of the group of         values when ranked in ascending or descending order. If the         number of values in the data set is odd, the median is the         middle value. If the number of values in the data set is even,         the median is the arithmetic mean of the two middle values.

Examples were synthesized one or more times. When synthesized more than once, data from biological assays represent average values calculated utilizing data sets obtained from testing of one or more synthetic batch.

Biological Assay 1.0:

Bub1 kinase assay

Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRET) kinase assay which measures phosphorylation of the synthetic peptide Biotin-Ahx-VLLPKKSFAEPG (SEQ ID No.1) (C-terminus in amide form), purchased from e.g. Biosyntan (Berlin, Germany) by the (recombinant) catalytic domain of human Bub1 (amino acids 704-1085), expressed in Hi5 insect cells with an N-terminal His6-tag and purified by affinity-(Ni-NTA) and size exclusion chromatography.

In a typical assay 11 different concentrations of each compound (0.1 nM, 0.33 nM, 1.1 nM, 3.8 nM, 13 nM, 44 nM, 0.15 μM, 0.51 μM, 1.7 μM, 5.9 μM and 20 μM) were tested in duplicate within the same microtiter plate. To this end, 100-fold concentrated compound solutions (in DMSO) were previously prepared by serial dilution (1:3.4) of 2 mM stocks in a clear low volume 384-well source microtiter plate (Greiner Bio-One, Frickenhausen, Germany), from which 50 nl of compounds were transferred into a black low volume test microtiter plate from the same supplier. Subsequently, 2 μL of Bub1 (the final concentration of Bub1 was adjusted depending on the activity of the enzyme lot in order to be within the linear dynamic range of the assay: typically ˜200 ng/mL were used) in aqueous assay buffer [50 mM Tris/HCl pH 7.5, 10 mM magnesium chloride (MgCl2), 200 mM potassium chloride (KCI), 1.0 mM dithiothreitol (DTT), 0.1 mM sodium ortho-vanadate, 1% (v/v) glycerol, 0.01% (w/v) bovine serum albumine (BSA), 0.005% (v/v) Trition X-100 (Sigma), 1× Complete EDTA-free protease inhibitor mixture (Roche)] were added to the compounds in the test plate and the mixture was incubated for 15 min at 22° C. to allow pre-equilibration of the putative enzyme-inhibitor complexes before the start of the kinase reaction, which was initiated by the addition of 3 μL 1.67-fold concentrated solution (in assay buffer) of adenosine-tri-phosphate (ATP, 10 μM final concentration) and peptide substrate (1 μM final concentration). The resulting mixture (5 μL final volume) was incubated at 22° C. during 60 min. and the reaction was stopped by the addition of 5 μL of an aqueous EDTA-solution (50 mM EDTA, in 100 mM HEPES pH 7.5 and 0.2% (w/v) bovine serum albumin) which also contained the TR-FRET detection reagents (0.2 μM streptavidin-XL665 [Cisbio Bioassays, Codolet, France] and 1 nM anti-phosho-Serine antibody [Merck Millipore, cat. # 35-002] and 0.4 nM LANCE EU-W1024 labeled anti-mouse IgG antibody [Perkin-Elmer, product no. AD0077, alternatively a Terbium-cryptate-labeled anti-mouse IgG antibody from Cisbio Bioassays can be used]). The stopped reaction mixture was further incubated 1 h at 22° C. in order to allow the formation of complexes between peptides and detection reagents. Subsequently, the amount of product was evaluated by measurement of the resonance energy transfer from the Eu-chelate-antibody complex recognizing the Phosphoserine residue to the streptavidin-XL 665 bound to the biotin moiety of the peptide. To this end, the fluorescence emissions at 620 nm and 665 nm after excitation at 330-350 nm were measured in a TR-FRET plate reader, e.g. a Rubystar or Pherastar (both from BMG Labtechnologies, Offenburg, Germany) or a Viewlux (Perkin-Elmer) and the ratio of the emissions (665 nm/622 nm) was taken as indicator for the amount of phosphorylated substrate. The data were normalised using two sets of control wells for high—(=enzyme reaction without inhibitor=0% =Minimum inhibition) and low—(=all assay components without enzyme=100%=Maximum inhibition) Bub1 activity. IC₅₀ values were calculated by fitting the normalized inhibition data to a 4-parameter logistic equation (Minimum, Maximum, IC_(50,) Hill; Y =Max+(Min-Max)/(1+(X/IC₅₀)Hill)).

TABLE 1 Inhibition of Bub1 kinase Example IC₅₀ Nr. [nM] 1 13 2 62 3 125 4 33 5 29 6 37 7 70 8 10 9 117 10 10 11 32 12 10 13 20 14 10 15 14 16 45 17 9 18 8 19 16 20 21 21 25 22 30 23 14 24 10 25 7 26 13 27 47 28 24 29 27 30 8 31 40 32 9 33 16 34 291 35 19 36 8 37 85 39 14 40 5 41 52 42 38 43 65 44 37 45 6010 46 12 47 13 48 7 49 179 50 9 51 8 52 64 53 103 54 15 55 23 56 55 57 69 58 4 59 4 60 14 61 17 62 5 63 4 64 21 65 44 66 19 67 116 68 88 69 34 70 34 71 37 72 46 73 19 74 7 75 22 76 7 77 20 78 8 79 37 80 10 81 6 82 68 83 16 84 29 85 3 86 28 87 83 88 153 89 66 90 232 91 16 92 37 93 94 94 15 95 83 96 57 97 13 98 27 99 22 100 65 101 53 102 5 103 15 104 19 105 14 106 16 107 12 108 35 109 11 110 27 111 21 112 32 113 25 114 14 115 21 116 62 117 56 118 49 119 29 120 31 121 19 122 7 123 19 124 38 125 46 126 47 127 47 128 38 129 30 130 14 131 81 132 91 133 29 134 18 135 19 136 11 137 173 138 12 139 18 140 65 141 91 142 6 143 7 144 169 145 40 146 59 147 61 148 27 149 17 150 10 151 7 152 13 153 12 154 11 155 14 156 9 157 7 158 106 159 18 160 5 161 56 162 8 163 13 164 11 165 161 166 573 167 10 168 17 169 26 170 13 171 22 172 400 173 15 174 1690 175 103 176 131 177 153 178 60 179 932 180 588 181 52 182 2360 183 89 184 1820 185 925 186 1150 187 156 188 480 189 8 190 8 191 19 192 49 193 411 194 63 195 5 196 8 197 7 198 15 199 13 200 38 202 25 203 7 204 29 205 38 206 22 207 19 208 11 209 16 210 81 211 11 212 37 213 206 214 88 215 19 216 11 217 11 218 17 219 15 220 32 221 40 222 119 223 19 224 142 225 37 226 18 227 73 228 32 229 8 230 10 231 8 232 12 233 70 234 18 235 13 236 30 237 119 238 247 239 8 240 13 241 56 242 11 243 27 244 60 245 194 246 127 247 639 248 1610 249 1090 250 241 251 42 252 19 253 236 254 56 255 28 256 31 257 31 258 28 259 136 260 97 261 19 262 9 263 25 264 462 265 29 266 40 267 15 268 18 269 27 270 20 271 10 274 27 275 58 276 10 277 19 278 30 279 55 280 5 281 23 282 5 283 4 284 9 285 7 286 10 287 7 288 3 290 10 291 10 294 296 11 297 60 298 52 299 60 300 92 301 94 302 99 303 261 304 nd 305 nd 306 nd 307 nd 308 639 309 nd 310 nd 311 nd nd: not determined 

1. A compound of formula (I),

wherein: R¹ is hydrogen or C₁-C₆-alkyl; R² is hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-; wherein said C₂-C₄-alkenyl is optionally substituted with halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴, R³ is hydrogen or C₁-C₆-alkyl; A is a group selected from:

wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one or more times, independently from each other, with R⁴; R⁴ is halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, C₁-C₄-hydroxyalkyl, C₁-C₄-alkyl-C(O)—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, C₁-C₄-alkyl-C(O)—NH—, R⁷R⁸N—, or R⁷R⁸N—SO₂—; E is a group

wherein * indicates the point of attachment of said group with the rest of the molecule; R⁵ is, independently from each other, halogen, hydroxy, nitro, cyano, R⁹R¹⁰N—, (R¹³—C(O)—)(R¹⁴—C(O)—)N—, C₁-C₄-alkyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₁-C₄-haloalkyl, C₁-C₆-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—, wherein said C₁-C₄-alkoxy is optionally substituted, one or more times, independently from each other, with a substituent selected from hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl, and 4- to 6-membered heterocycloalkyl; Q is O or N—OH; R⁶ is, independently from each other, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl, wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, nitro, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted, one or more times, independently from each other, with R⁴, wherein said C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, nitro, cyano, C₁-C₆-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or C₁-C₄-haloalkoxy; R⁷, R⁸ represent are, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl, wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl optionally substituted one time with hydroxy, 4- to 6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴; or, R⁷ and R⁸ together with the nitrogen atom to which they are attached form a 4- to 7-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom selected from O, NR⁹ and S, and which may be optionally substituted, one or more times, independently from each other, with R¹²; whereby when two R¹² substituents are attached to the same ring carbon atom, together with the carbon atom to which they are attached, can be linked to one another in such a way that they jointly form a cyclobutane, azetidine, or oxetane group; said azetidine being optionally substituted one time with C₁-C₃-alkyl, or, R⁷ and R⁸ together with the nitrogen atom to which they are attached form a group selected from :

wherein * indicates the point of attachment of said group with the rest of the molecule, R⁹ is hydrogen, or C₁-C₆-alkyl; R¹⁰ is hydrogen, C₁-C₆-alkyl or C₃-C₆-cycloalkyl; R¹¹ is hydroxy, nitro, cyano, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, C₁-C₄-alkyl-C(O)—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—, R⁷R⁸N—SO₂—; wherein said C₃-C₆-cycloalkyl or 4- to 6-membered heterocycloalkyl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy, wherein said C₁-C₄-alkoxy is optionally substituted with phenyl, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴, R¹² is halogen, hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, or R⁹R¹⁰N—; R¹³, R¹⁴ are, independently from each other, C₁-C₄-alkyl, or C₃-C₆-cycloalkyl, wherein said C₃-C₆-cycloalkyl is optionally substituted, one or more times, independently from each other, with halogen; m is 0, 1 or 2; or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 2. The compound of formula (I) according to claim 1: wherein: R¹ is hydrogen or C₁-C₄-alkyl; R² is hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-; wherein said C₂-C₄-alkenyl is optionally substituted with halogen, R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴, R³ is hydrogen or C₁-C₄-alkyl; A is a group selected from:

wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one or more times, independently from each other, with R⁴; R⁴ is halogen, hydroxy, nitro, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, or C₁-C₄-haloalkoxy; E is a group

wherein * indicates the point of attachment of said group with the rest of the molecule; R⁵ is, independently from each other, halogen, hydroxy, cyano, R⁹R¹⁰N—, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—, wherein said C₁-C₄-alkoxy is optionally substituted, one or more times, independently from each other, with a substituent selected from hydroxy, C₁-C₄-alkoxy, and C₃-C₆-cycloalkyl; Q is O or N—OH; R⁶ is, independently from each other, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl, wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, cyano, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted, one or more times, independently from each other, with R⁴, wherein said C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, R¹⁰—O—C(O)— or C₁-C₄-haloalkoxy; R⁷, R⁸ represent are, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, R¹⁰—O—C(O)— or phenyl, wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, C₃-C₆-cycloalkyl optionally substituted one time with hydroxy, 4- to 6-membered heterocycloalkyl, heteroaryl, or R⁹R¹⁰N—, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴; R⁷ and R⁸ together with the nitrogen atom to which they are attached form a 4- to 7-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom selected from O, NR⁹ and S, and which may be optionally substituted, one or more times, independently from each other, with R¹²; R⁹ is hydrogen or C₁-C₄-alkyl; R¹⁰ is hydrogen, C₁-C₄-alkyl, or C₃-C₄-cycloalkyl; R¹¹ is hydroxy, cyano, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R⁷R⁸N—, N₃—, R⁶ —C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, or R⁶—SO—, R⁶—SO₂—; wherein said C₃-C₆-cycloalkyl or 4- to 6-membered heterocycloalkyl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy, wherein said C₁-C₄-alkoxy is optionally substituted with phenyl, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴, R¹² is halogen, hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, C₁-C₄-haloalkoxy, or R⁹R¹⁰N—; m is 0, 1 or 2; or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 3. The compound of formula (I) according to claim 1, wherein: R¹ is hydrogen or C₁-C₂-alkyl; R² is hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-; wherein said C₂-C₄-alkenyl is optionally substituted with R¹⁰—O—C(O)—, R⁷R⁸N— or phenyl, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴, R³ is hydrogen or C₁-C₄-alkyl; A is a group selected from:

wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one or more times, independently from each other, with R⁴; R⁴ is halogen; E is a group

wherein * indicates the point of attachment of said group with the rest of the molecule; R⁵ is, independently from each other, halogen, R⁹R¹⁰N—, C₁-C₄-alkoxy, C₁-C₄-haloalkoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—, wherein said C₁-C₄-alkoxy is optionally substituted, one or more times, independently from each other, with a substituent selected from hydroxy, C₁-C₄-alkoxy, and C₃-C₄-cycloalkyl; Q is O; R⁶ is, independently from each other, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl, wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C₁-C₂-alkoxy, C₃-C₄-cycloalkyl, R⁷R⁸N— or phenyl optionally substituted, one or more times, independently from each other, with R⁴, wherein said C₃-C₆-cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl or heteroaryl groups are optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C₁-C₄-alkyl, tert-butyl-O—C(O)—, or C₁-C₄-alkoxy; R⁷, R⁸ are, independently from each other, hydrogen, C₁-C₆-alkyl, C₃-C₄-cycloalkyl, tert-butyl-O—C(O)— or phenyl, wherein said C₁-C₆-alkyl is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, C₁-C₄-alkoxy, C₃-C₆-cycloalkyl optionally substituted one time with hydroxy, 4- to 6-membered heterocycloalkyl, heteroaryl, or R⁹ _(R) ¹⁰N—, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴; R⁷ and R⁸ together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom selected from O and NR⁹, and which may be optionally substituted, one or more times, independently from each other, with R¹²; R⁹ is hydrogen or C₁-C₂-alkyl; R¹⁰ is hydrogen or C₁-C₄-alkyl; R¹¹ is hydroxy, 6-membered heterocycloalkyl, C₁-C₂-alkoxy, R⁷R⁸N—, N₃—, R⁶—C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, R⁶—SO₂—; wherein said 6-membered heterocycloalkyl group is optionally substituted, one or more times, independently from each other, with halogen, hydroxy, cyano, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl or C₁-C₄-haloalkoxy, wherein said C₁-C₄-alkoxy is optionally substituted with phenyl, wherein said phenyl group is optionally substituted, one or more times, independently from each other, with R⁴, R¹² is halogen, hydroxy, C₁-C₂-alkyl, R⁹R¹⁰N—; m is 0, or 1; or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 4. The compound of formula (I) according to claim 1, wherein R¹ is hydrogen or methyl; R² is hydroxy, C₂-C₄-alkenyl, R⁷R⁸N—, R¹⁰—O—C(O)—, R⁷R⁸N—C(O)—, R⁶—C(O)—NR⁹—, or R¹¹—(C₁-C₄-alkyl)-; wherein said C₂-C₄-alkenyl is optionally substituted with HO—C(O)—, (CH₃)₂N— or phenyl, wherein said phenyl group is optionally substituted one, two or three times with F, R³ is hydrogen, methyl or ethyl; A is a group selected from:

wherein * indicates the point of attachment of said group with the rest of the molecule and said group is optionally substituted, one or two times, independently from each other, with R⁴; R⁴ is fluoro or chloro; E is a group

wherein * indicates the point of attachment of said group with the rest of the molecule; R⁵ is, independently from each other, fluoro, R⁹R¹⁰N—, C₁-C₂-alkoxy, difluoroethoxy, R⁶—C(O)—NR⁹— or R⁷R⁸N—C(O)—NR⁹—, wherein said C₁-C₂-alkoxy is optionally substituted, one or two times, independently from each other, with a substituent selected from hydroxy, methoxy, and cyclopropyl; Q is O; R⁶ is, independently from each other, C₁-C₅-alkyl, C₃-C₄-cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or 5- to 6-membered heteroaryl, wherein said C₁-C₅-alkyl is optionally substituted, one, two or three times, independently from each other, with fluoro, hydroxy, methoxy, cyclopropyl, or R⁷R⁸N— and optionally substituted one time with phenyl optionally substituted, one, two or three times, independently from each other, with R⁴, wherein said C₃-C₄-cycloalkyl, 5- to 6-membered heterocycloalkyl, phenyl or heteroaryl groups are optionally substituted, one, two or three times, independently from each other, with fluoro, chloro, hydroxy, methyl, tert-butyl-O—C(O)—, methoxy; R⁷, R⁸ are, independently from each other, hydrogen, C₁-C₅-alkyl, cyclopropyl, cyclobutyl, tert-butyl-O—C(O)— or phenyl, wherein said C₁-C₅-alkyl is optionally substituted, one or more times, independently from each other, with fluoro, hydroxy, methoxy, C₃-C₄-cycloalkyl optionally substituted one time with hydroxy, 5-membered heterocycloalkyl, 5-membered heteroaryl, or R⁹ _(R) ¹⁰N—, wherein said phenyl group is optionally substituted, one, or two times, independently from each other, with fluoro or chloro; R⁷ and R⁸ together with the nitrogen atom to which they are attached form a 4- to 6-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom selected from O and NR⁹, and which may be optionally substituted, one or two times, independently from each other, with R¹²; R⁹ is hydrogen or methyl; R¹⁰ is hydrogen, methyl or tert-butyl; R¹¹ is hydroxy, morpholino, methoxy, R⁷R₈N—, N₃—, R⁶ —C(O)—NR⁹—, R⁶—O—C(O)—NR⁹—, R⁷R⁸N—C(O)—NR⁹—, R⁶—SO₂—NR⁹—, R⁶—S—, R⁶—SO—, or R⁶—SO₂—; wherein said methoxy group is optionally substituted with phenyl; R¹² is fluoro, hydroxy, methyl, or R⁹R¹⁰N—; m is 0, or 1; or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 5. The compound according to claim 1, which is selected from the group consisting of: (6RS)-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, tert-butyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate, (6RS)-6-[(benzyloxy)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, tert-butyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]carbamate, (6RS)-6-amino-3-anilino-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one hydrochloride, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]cyclopropanecarboxamide, (6RS)-4-oxo-N-phenyl-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, 4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-hydroxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, methyl (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, methyl (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-N-(2-methoxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-ethyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-6-(morpholin-4-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-3-(phenylamino)-2-(pyridin-4-yl)-6-(pyrrolidin-1-ylcarbonyl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-(azetidin-1-ylcarbonyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-N-(cyclopropylmethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(cyclopropylmethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide (6RS)-N-ethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-tert-butyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-(phenylamino)-6-(piperidin-1-ylcarbonyl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-4-oxo-3-(phenylamino)-N-(propan-2-yl)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, methyl (6RS)-2-(2-aminopyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-6-(azidomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(dimethylamino)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-hydroxymethyl)-1-methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[tert-butyl(dimethyl)silyl]oxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-(aminomethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-1-ethyl-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-1-[2-(dimethylamino)ethyl]-6-(hydroxymethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-hydroxy-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-ethenyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, 1-ethyl-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea, 1-cyclopropyl-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea, 1-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-3-propan-2-ylurea, 1-(furan-2-ylmethyl)-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea, 1-(3-chloro-4-fluorophenyl)-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylurea, methyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylacetamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylmethanesulfonamide, (6RS)-2-(3-methoxypyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, methyl (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (4E)-5-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid, (4Z)-5-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid, (6RS)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-6-[(E)-2-(4-fluorophenyl)ethenyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(Z)-2-(4-fluorophenyl)ethenyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-(morpholin-4-ylmethyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[methyl(propan-2-yl)amino]methyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(1E)-3-(dimethylamino)prop-1-en-1-yl]-3 -(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(1Z)-3-(dimethylamino)prop-1-en-1-yl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, 1-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-3-(2RS)-(tetrahydrofuran-2-ylmethyl)urea, (6RS)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6R)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6R)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6S)-N,N-dimethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6S)-N-methyl-4-oxo-3-(phenylamino)-N-propyl-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(ethylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, 4-fluoro-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylbenzenesulfonamide, 2-methoxyethyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate, 2-fluoroethyl [(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamate, (6RS)-6-[(1,3-benzothiazol-2-ylsulfanyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcyclopropanecarboxamide, 2-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide, 2-methoxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylacetamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcyclobutanecarboxamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropane-2-sulfonamide, (6RS)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6R)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6S)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-(3-methoxypyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-(3-fluoropyridin-4-yl)-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-hydroxyethyl)-2-(3-methoxypyridin-4-yl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(ethylsulfonyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, 3-methoxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide, (6RS)-2-[2-(acetylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-(acetylamino)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, methyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, methyl (6R)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, methyl (6S)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-2-(2-aminopyridin-4-yl)-6-(hydroxymethyl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one, 4-fluoro-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylbenzamide, tert-butyl [(2S)-1-oxo-1-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylamino)propan-2-yl]carbamate, tert-butyl (2S)-2-([(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylcarbamoyl)pyrrolidine-1-carboxylate, (2S)-2-hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylpropanamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-1,3-thiazole-2-carboxamide, 1-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-1H-pyrrole-2-carboxamide, N-4-[(6RS)-6-(hydroxymethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyltetrahydro-2H-pyran-4-carboxamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methylfuran-2-carboxamide, (6RS)-N-(2-hydroxy-2-methylpropyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2S)-2-hydroxypropyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(1-hydroxy-2-methylpropan-2-yl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indole-6-carboxamide, (6RS)-N-(2,2-dimethylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[2-(dimethylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[2-(dimethylamino)ethyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-N-[2-(methylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2,2-difluoroethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2,2-difluoroethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-tert-butyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(1-hydroxycyclopropyl)methyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-hydroxy-2-methylpropyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2R)-2-hydroxypropyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6R)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6S)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-6-[(4-methylpiperazin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl-3-(phenylamino)-2-(p yridin-4-yl)-1,5,6,7 -tetrahydro-4H-indol-4-one, (6RS)-6-[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-[(3-hydroxyazetidin-1-yl)carbonyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-N,N-diethyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]acetamide, 2-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]propanamide, 3-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide, 3-hydroxy-3-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide, 2-cyclopropyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]acetamide, (3S)-3-hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide, 3-hydroxy-2,2-dimethyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]propanamide, (6RS)-N-[(2S)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6R)-N-[(2S)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6S)-N-[(2S)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2R)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6R)-N-[(2R)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (3R)-3-hydroxy-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide, (6S)-N-[(2R)-1-hydroxypropan-2-yl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[2-(methylamino)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl-L-prolinamide, tert-butyl methyl(3-oxo-3-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1 1H-indol-6-yl]aminopropyl)carbamate, methyl (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-6-[(1,3-benzothiazol-2-ylsulfonyl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-[2-([(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-2-[2-(acetylamino)pyridin-4-yl]-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, methyl (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, methyl (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, 3,3-dimethyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]butanamide, (6RS)-2-2-[(4-fluorobenzoyl)amino]pyridin-4-yl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, N³-methyl-N-[(6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]-beta-alaninamide trifluoroacetate, (6RS)-N-[(1-hydroxycyclobutyl)methyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (4E)-5-[(6RS)-2-[2-(acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pent-4-enoic acid, methyl (6RS)-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, N-4-[(6RS)-6-(azidomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, (6RS)-N-(2-methoxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-([rel-(1R,2R)-2-fluorocyclopropyl]carbonylamino)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2,2-dimethylpropyl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-4-[(6RS)-6-(aminomethyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, Methyl (6RS)-3-anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-2-[3—(Cyclopropylmethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, Methyl (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-3-Anilino-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-2-[3-(2-Methoxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-Hydroxyethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, Methyl (6RS)-3-anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-2-[3-(2-Hydroxyethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-2-[3-(2,2-Difluoroethoxy)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid (6RS)-N-Ethyl-N-(2-hydroxyethyl)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-Hydroxyethyl)-4-oxo-3-(phenylamino)-N-(propan-2-yl)-2-(pyridin-4-yl)-4,5,6,7 -tetrahydro-1H-indol-6-carboxamide, (6RS)-N-R¹-Hydroxycyclobutyl)methyl) -N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2R)-1-Hydroxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2S)-1-Hydroxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-(4-{(6RS)-3-Anilino-6-methyl-6-[(4-methylpiperazin-1-yl)carbonyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide, (6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-{4-[(6RS)-3-Anilino-6-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl }-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-(4-{(6RS)-3-Anilino-6-[(3-fluoroazetidin-1-yl)carbonyl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide, N-(4-{(6RS)-3-Anilino-6-[(3,3-difluoroazetidin-1-yl)carbonyl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-methoxyethyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,N-diethyl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-4-[(6RS)-6-Methyl-6-azaspiro[3 .3]hept-6-ylcarbonyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-2-methoxypropyl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-[(2S)-1-methoxypropan-2-yl]-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2-methoxy-2-methylpropyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,6-dimethyl-4-oxo-3-(phenylamino)-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N-(2,2-dimethylpropyl)-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-4-[(6RS)-6-[(3R)-3-(Dimethylamino)pyrrolidin-1-yl]carbonyl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-4-[(6RS)-6-Methyl-6-[(1R,4R)-5-methyl-2,5-diazabicyclo [2.2.1]hept-2-yl]carbonyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, (6RS)-2-[2-(Acetylamino)pyridin-4-yl]-N,6-dimethyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-4-[(6RS)-6-Methyl-6-[(1R,4R)-2-oxa-5-azabicyclo [2.2.1]hept-5-ylcarbonyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-4-[(6RS)-6-[(Ethylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide, N-4-[(6RS)-6-[(tert-Butylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(S)-propan-2-ylsulfinyl]methyl-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-(2-Aminopyridin-4-yl)-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N-(2-hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N,N-Dimethyl-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(2-Hydroxyethyl)-N-methyl-4-oxo-3-(phenylamino)-2-2-[(1,3-thiazol-5-ylcarbonyl)amino]pyridin-4-yl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-{4-[(6RS)-3-Anilino-6-{[(methylsulfonyl)amino]methyl }-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-{4-[(6RS)-6-(Acetamidomethyl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-{[(6RS)-2-(2-Acetamidopyridin-4-yl)-3-anilino-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl}-4′-methoxybiphenyl-4-carboxamide, 5-[(6RS)-2-[2-(Acetylamino)pyridin-4-yl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-yl]pentanoic acid, (6RS)-3-Anilino-N,N-diisopropyl-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[3-(2-hydroxyethoxy)pyridin-4-yl]-N-(2-hydroxyethyl)-N-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, Methyl (6RS)-3-anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl }amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-3-Anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl }amino)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6RS)-3-Anilino-2-[2-({[(1RS)-2,2-difluorocyclopropyl]carbonyl }amino)pyridin-4-yl]N,N-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-4-fluoro-3-methoxybenzamide, N-(4-{(6RS)-3-Anilino-6-[isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-2-fluoro-2-methylpropanamide, 1-(4-{(6RS)-3-Anilino-6-[isopropylsulfanyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-3-cyclopropylurea, 1-(4-{(6RS)-3-Anilino-6-[isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-3-cyclopropylurea, N-{[(6RS)-3-Anilino-4-oxo-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-yl]methyl}-L-alaninamide, (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl }amino)pyridin-4-yl]N,N,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-N,N-diethyl-2-[2-({[(1S ,2S)-2-fluorocyclopropyl]carbonyl }amino)pyridin-4-yl]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]N,6-dimethyl-4-oxo-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[2-({[(1S ,2S)-2-fluorocyclopropyl]carbonyl }amino)pyridin-4-yl]N-isobutyl-N,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-N-(cyclopropylmethyl)-2-[2-({[(1S,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-3-Anilino-2-[2-({[(1S ,2S)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]-N,6-dimethyl-4-oxo-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (1S ,2S)-N-{4-[(6RS )-3-Anilino-6-methyl-4-oxo-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide, (1S ,2S)-N-{4-[(6RS)-3-Anilino-6-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide, (1S ,2S)-N-{4-[(6RS)-3-Anilino-6-methyl-4-oxo-6-(piperidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-2-fluorocyclopropanecarboxamide, N-{4-[(6RS)-3-Anilino-6-({[2-(dimethylamino)ethyl]sulfanyl}methyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)-4-fluoro-N-methylbenzamide, (6RS)-2-(2-Aminopyridin-4-yl)-6-(hydroxymethyl)-6-methyl-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one, N-4-[(6RS)-6-[(2-Methoxyethyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-4-[(6RS)-6-[(1,3-Oxazol-2-ylsulfanyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(1,3-thiazol-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide, N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(pyridin-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide, N-4-[(6RS)-6-[(4-Fluorobenzyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, (1S,2S)-2-Fluoro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)cyclopropanecarboxamide, N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)-1,3-thiazole-5-carboxamide, 4-Fluoro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide, 4-Chloro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide, 3,4-Dichloro-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfanyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide N-4-[(6RS)-6-[(Ethylsulfonyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-(4-(6RS)-Oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)acetamide, 2-Fluoro-2-methyl-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)propanamide, 4-Fluoro-3-methoxy-N-(4-(6RS)-4-oxo-3-(phenylamino)-6-[(propan-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-ylpyridin-2-yl)benzamide, N-4-[(6RS)-6-[tert-Butylsulfonyl)methyl]-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,N,6-trimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-N-propyl-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N,N-Diethyl-2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-N-(2-methylpropyl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-2-2-[(2-Fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-N-(3,3,3-trifluoropropyl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(Cyclopropylmethyl)-2-2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl-N,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, 2-Fluoro-2-methyl-N-4-[(6RS)-6-methyl-4-oxo-3-(phenylamino)-6-(pyrrolidin-1-ylcarbonyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylpropanamide, N-{4-[(6RS)-3-Anilino-6-{[(4-fluorophenyl)sulfanyl]methyl }-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-(4-{(6RS)-3-Anilino-6-[(isopropylsulfonyl)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)morpholine-4-carboxamide, N-{4-[(6RS)-3-Anilino-6-{[(3,4-dichlorophenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamid, N-{4-[(6RS)-3-Anilino-6-{[(4-chlorophenyl)sulfanyl]methyl }-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-4-[(6RS)-6-[(4-Fluoro-3-methoxyphenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-4-[(6RS)-6-[(3,4-Difluorophenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, N-4-[(6RS)-6-[(4-Methoxyphenyl)sulfanyl]methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-ylacetamide, Methyl (6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-2-(2-Aminopyridin-4-yl)-3-anilino-6-[(isopropylsulfanyl)methyl]-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one, N-(4-{(6RS)-3-Anilino-4-oxo-6-[(1,3-thiazol-2-ylsulfonyl)methyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}pyridin-2-yl)acetamide, N-{4-[(6RS)-3-Anilino-6-{[(4-fluoro-3-hydroxyphenyl)sulfanyl]methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-{4-[(6RS)-3-Anilino-6-{[(2-methoxyethyl)sulfonyl]methyl }-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-{4-[(6RS)-3-Anilino-{[(4-fluorobenzyl)sulfonyl]methyl }-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, (6RS)-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, tert-butyl (6RS)-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-N,N-dimethyl-4-oxo-2-(pyridin-4-yl)-3-(pyridin-2-ylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2S)-2-hydroxypropyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2R)-2-hydroxypropyl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-N-[2-(pyrrolidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-methyl-N-[2-(morpholin-4-yl)ethyl]-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-cyclobutyl-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-[(2S)-1-methoxypropan-2-yl]-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-N-(1-methoxy-2-methylpropan-2-yl)-N-methyl-4-oxo-3-(phenylamino)-2-(pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, methyl (6R)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, methyl (6S)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6S)-2-(3-fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6R)-2-(3 -fluoropyridin-4-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6S)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7 -tetrahydro-1H-indol-6-carboxamide, (6R)-2-(3-fluoropyridin-4-yl)-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide, (6RS)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6R)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6S)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, N-{4-[(6RS)-6-(2-hydroxypropan-2-yl)-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, N-{4-[(6RS)-6-(2-hydroxypropan-2-yl)-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7 -tetrahydro-1H-indol-2-yl]pyridin-2-yl}acetamide, (6RS)-2-(3-fluoropyridin-4-yl)-6-(2-hydroxypropan-2-yl)-3-(phenylamino)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-3-(phenylamino)-6-(prop-2-en-1-yl)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-3-(phenylamino)-6-(prop-2-en-1-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-2-[3-(cyclopropylmethoxy)pyridin-4-yl]-3-(phenylamino)-6-(prop-2-en-1-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-3-[(3-fluorophenyl)amino]-6-(hydroxymethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-6-{[4-(dimethylamino)piperidin-1-yl]methyl }-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7 -tetrahydro-4H-indol-4-one, (6RS)-6-[(4-methylpiperazin-1-yl)methyl]-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-indol-4-one, 4-fluoro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide, N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl }-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-1,3-thiazole-5-carboxamide, (1S ,2S)-2-fluoro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl }-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl }cyclopropanecarboxamide, 4-chloro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl }-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide, 3,4-dichloro-N-{4-[(6RS)-4-oxo-3-(phenylamino)-6-{[(RS)-propan-2-ylsulfinyl]methyl}-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}benzamide, (6RS)-6-(aminomethyl)-3-[(3-fluorophenyl)amino]-2-[3-(2-methoxyethoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-indol-4-one, (6RS)-N-({3-[(3-fluorophenyl)amino]-2-[3-(2-methoxyethoxy)pyridin-4-yl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-yl}methyl)acetamide, methyl (6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, methyl (6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylate, (6RS)-2-(2-aminopyridin-4-yl)-6-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid, (6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7 -tetrahydro-1H-indol-6-carboxylic, (6S)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7 -tetrahydro-1H-indol-6-carboxylic acid hydrochloride, (6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic, (6R)-2-(2-aminopyridin-4-yl)-3-[(3-fluorophenyl)amino]-6-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-6-carboxylic acid hydrochloride, and (6RS)-3-[(3-fluorophenyl)amino]-6-(hydroxymethyl)-2-[3-(2-methoxyethoxy)pyridin-4-yl]-6-methyl-1,5,6,7-tetrahydro-4H-indol-4-one, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 6. A method of preparing a compound of general formula (I) according to claim 1, said method comprising the step of allowing an intermediate compound of general formula (17):

wherein R¹, R², A and E are as defined for the compound of formula (I) in claim 1, with a base and/or oxidizing reagent, preferably an oxidizing agent, such as, for example hydrogen peroxide, thereby giving a compound of general formula (I) :

wherein R¹, R², A and B are as defined for the compound of formula (I) in claim
 1. 7. A method of preparing a compound of general formula (I) according to claim 1, said method comprising the step of allowing an intermediate compound of general formula (20) :

wherein R¹, R², and E are as defined for the compound of formula (I) in claim 1, with an amine of formula A-NH₂ wherein A is as defined for the compound of formula (I) in claim 1, thereby giving a compound of general formula (I):

wherein R¹, R², A and E are as defined for the compound of formula (I) in claim
 1. 8. A method of treatment or prophylaxis of a disease, comprising administering to a patient in need thereof a therapeutically effective amount of the compound of formula (I) according to claim 1, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 9. A method of treatment or prophylaxis of a disease, wherein the disease is a hyperproliferative disease and/or disorder responsive to induction of cell death, comprising administering to a patient in need thereof a therapeutically effective amount of the compound of formula (I) according to claim 1, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer.
 10. The method of claim 9, wherein the hyperproliferative disease and/or disorder responsive to induction of cell death is a haematological tumour, solid tumour and/or metastases thereof.
 11. The method of claim 10, wherein the tumor is selected from cervical -, breast -, non-small cell lung -, prostate -, colon- and melanoma tumor and/or metastases thereof.
 12. A pharmaceutical composition comprising at least one compound according to claim 1, together with at least one pharmaceutically acceptable auxiliary.
 13. (canceled)
 14. A combination comprising one or more first active ingredients selected from a compound according to claim 1, and one or more second active ingredients selected from chemotherapeutic anti-cancer agents and target-specific anti-cancer agents.
 15. A compound selected from:

wherein R¹, R², A, and E have the meaning according to claim 1; and

wherein R¹, R², E have the meaning according to claim
 1. 16. A method of preparing a compound of formula (I) according to claim 1, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer thereof, said method comprising using a compound according to claim
 15. 17. A method of treatment or prophylaxis of a disease, wherein the disease is a hyperproliferative disease and/or disorder responsive to induction of cell death, comprising administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition according to claim
 12. 18. The method of claim 17, wherein the hyperproliferative disease and/or disorder responsive to induction of cell death is a haematological tumour, solid tumour and/or metastases thereof.
 19. The method of claim 18, wherein the tumor is selected from cervical -, breast -, non-small cell lung -, prostate -, colon- and melanoma tumor and/or metastases thereof. 